Regulation of alternative splicing through coupling with transcription and chromatin structure
Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of genetic information from DNA to proteins by expanding the coding capacity of genomes. Regulation of alternative splicing is as important as regulation of transcription to determine cell- and tissue-specific f...
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2015
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00664154_v84_n_p165_Naftelberg http://hdl.handle.net/20.500.12110/paper_00664154_v84_n_p165_Naftelberg |
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paper:paper_00664154_v84_n_p165_Naftelberg2023-06-08T15:06:08Z Regulation of alternative splicing through coupling with transcription and chromatin structure Alternative splicing Chromatin organization Histone modifications Molecular evolution Nucleosome positioning Transcription adaptor protein histone RNA polymerase II chromatin nucleosome alternative RNA splicing chromatin structure density DNA methylation histone modification human kinetics machine nonhuman nucleosome priority journal Review animal biological model chromatin gene expression regulation genetic transcription metabolism protein processing Eukaryota Alternative Splicing Animals Chromatin DNA Methylation Gene Expression Regulation Histones Humans Models, Genetic Nucleosomes Protein Processing, Post-Translational Transcription, Genetic Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of genetic information from DNA to proteins by expanding the coding capacity of genomes. Regulation of alternative splicing is as important as regulation of transcription to determine cell- and tissue-specific features, normal cell functioning, and responses of eukaryotic cells to external cues. Its importance is confirmed by the evolutionary conservation and diversification of alternative splicing and the fact that its deregulation causes hereditary disease and cancer. This review discusses the multiple layers of cotranscriptional regulation of alternative splicing in which chromatin structure, DNA methylation, histone marks, and nucleosome positioning play a fundamental role in providing a dynamic scaffold for interactions between the splicing and transcription machineries. We focus on evidence for how the kinetics of RNA polymerase II (RNAPII) elongation and the recruitment of splicing factors and adaptor proteins to chromatin components act in coordination to regulate alternative splicing. Copyright © 2015 by Annual Reviews. All rights reserved. 2015 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00664154_v84_n_p165_Naftelberg http://hdl.handle.net/20.500.12110/paper_00664154_v84_n_p165_Naftelberg |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Alternative splicing Chromatin organization Histone modifications Molecular evolution Nucleosome positioning Transcription adaptor protein histone RNA polymerase II chromatin nucleosome alternative RNA splicing chromatin structure density DNA methylation histone modification human kinetics machine nonhuman nucleosome priority journal Review animal biological model chromatin gene expression regulation genetic transcription metabolism protein processing Eukaryota Alternative Splicing Animals Chromatin DNA Methylation Gene Expression Regulation Histones Humans Models, Genetic Nucleosomes Protein Processing, Post-Translational Transcription, Genetic |
| spellingShingle |
Alternative splicing Chromatin organization Histone modifications Molecular evolution Nucleosome positioning Transcription adaptor protein histone RNA polymerase II chromatin nucleosome alternative RNA splicing chromatin structure density DNA methylation histone modification human kinetics machine nonhuman nucleosome priority journal Review animal biological model chromatin gene expression regulation genetic transcription metabolism protein processing Eukaryota Alternative Splicing Animals Chromatin DNA Methylation Gene Expression Regulation Histones Humans Models, Genetic Nucleosomes Protein Processing, Post-Translational Transcription, Genetic Regulation of alternative splicing through coupling with transcription and chromatin structure |
| topic_facet |
Alternative splicing Chromatin organization Histone modifications Molecular evolution Nucleosome positioning Transcription adaptor protein histone RNA polymerase II chromatin nucleosome alternative RNA splicing chromatin structure density DNA methylation histone modification human kinetics machine nonhuman nucleosome priority journal Review animal biological model chromatin gene expression regulation genetic transcription metabolism protein processing Eukaryota Alternative Splicing Animals Chromatin DNA Methylation Gene Expression Regulation Histones Humans Models, Genetic Nucleosomes Protein Processing, Post-Translational Transcription, Genetic |
| description |
Alternative precursor messenger RNA (pre-mRNA) splicing plays a pivotal role in the flow of genetic information from DNA to proteins by expanding the coding capacity of genomes. Regulation of alternative splicing is as important as regulation of transcription to determine cell- and tissue-specific features, normal cell functioning, and responses of eukaryotic cells to external cues. Its importance is confirmed by the evolutionary conservation and diversification of alternative splicing and the fact that its deregulation causes hereditary disease and cancer. This review discusses the multiple layers of cotranscriptional regulation of alternative splicing in which chromatin structure, DNA methylation, histone marks, and nucleosome positioning play a fundamental role in providing a dynamic scaffold for interactions between the splicing and transcription machineries. We focus on evidence for how the kinetics of RNA polymerase II (RNAPII) elongation and the recruitment of splicing factors and adaptor proteins to chromatin components act in coordination to regulate alternative splicing. Copyright © 2015 by Annual Reviews. All rights reserved. |
| title |
Regulation of alternative splicing through coupling with transcription and chromatin structure |
| title_short |
Regulation of alternative splicing through coupling with transcription and chromatin structure |
| title_full |
Regulation of alternative splicing through coupling with transcription and chromatin structure |
| title_fullStr |
Regulation of alternative splicing through coupling with transcription and chromatin structure |
| title_full_unstemmed |
Regulation of alternative splicing through coupling with transcription and chromatin structure |
| title_sort |
regulation of alternative splicing through coupling with transcription and chromatin structure |
| publishDate |
2015 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00664154_v84_n_p165_Naftelberg http://hdl.handle.net/20.500.12110/paper_00664154_v84_n_p165_Naftelberg |
| _version_ |
1768545087652888576 |