Prostaglandin F2α (PGF2α) triggers Protein Kinase C (PKC) and tyrosine kinase activity in cultured mammalian cells

Prostaglandin F2α (PGF2α) added to confluent resting Swiss 3T3 cells triggers tyrosine kinase (PTK) activation characterized by the phosphorylation of a set of 75, 86, 110 and 140 kD proteins. PGF2α induces this event independently of PKC activation. However, both PKC and PTK activities appear to ac...

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Guardado en:
Detalles Bibliográficos
Publicado: 1997
Materias:
prostaglandin f2 alpha
protein kinase c
protein tyrosine kinase
insulin
phorbol 13 acetate 12 myristate
prostaglandin E1
prostaglandin F2 alpha
protein kinase C
animal cell
cell culture
cell division
cell proliferation
conference paper
dna synthesis
enzyme activation
enzyme activity
mammal
mitogenesis
mitosis
nonhuman
priority journal
protein phosphorylation
signal transduction
animal
article
biological model
cell strain 3T3
DNA replication
drug effect
kinetics
metabolism
mouse
phosphorylation
Animalia
Mammalia
3T3 Cells
Alprostadil
Animals
Cell Division
Dinoprost
DNA Replication
Enzyme Activation
Insulin
Kinetics
Mice
Models, Biological
Phosphorylation
Protein Kinase C
Protein-Tyrosine Kinases
Tetradecanoylphorbol Acetate
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00652598_v400_nA_p531_JimenezDeAsua
http://hdl.handle.net/20.500.12110/paper_00652598_v400_nA_p531_JimenezDeAsua
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:Prostaglandin F2α (PGF2α) added to confluent resting Swiss 3T3 cells triggers tyrosine kinase (PTK) activation characterized by the phosphorylation of a set of 75, 86, 110 and 140 kD proteins. PGF2α induces this event independently of PKC activation. However, both PKC and PTK activities appear to act concertedly to cause mitogenesis. Here we discuss their relevance in the control of mammalian cell division.

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