Chapter 7 Glycobiology of Trypanosoma cruzi

The glycobiology of Trypanosoma cruzi, the causative agent of Chagas' disease, has contributed significantly to the identification of target enzymes responsible for the construction of unique cell-surface molecules. The authors discuss the structure of glycoinositolphospholipids, both free and...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Muchnik de Lederkremer, Rosa María, Agustí, Rosalía
Publicado:	2009
Materias:	Chagas' disease Galactofuranose Glycoinositolphospholipids GPI anchors Inositolphosphoceramide Mucins trans-Sialidase Trypanosoma cruzi alditol amino acid antigen carbohydrate glycoconjugate glycoprotein lactose mucin phospholipid protein sialic acid derivative sialidase membrane protein binding site carbohydrate analysis catalysis cell surface genetic variability glycobiology insect life cycle nonhuman parasite priority journal review sialylation animal biosynthesis chemistry growth, development and aging immunology metabolism molecular genetics Mammalia Animals Carbohydrate Sequence Glycoconjugates Glycomics Life Cycle Stages Membrane Glycoproteins Molecular Sequence Data
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00652318_v62_n_p311_deLederkremer http://hdl.handle.net/20.500.12110/paper_00652318_v62_n_p311_deLederkremer
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00652318_v62_n_p311_deLederkremer
record_format	dspace
spelling	paper:paper_00652318_v62_n_p311_deLederkremer2023-06-08T15:05:58Z Chapter 7 Glycobiology of Trypanosoma cruzi Muchnik de Lederkremer, Rosa María Agustí, Rosalía Chagas' disease Galactofuranose Glycoinositolphospholipids GPI anchors Inositolphosphoceramide Mucins trans-Sialidase Trypanosoma cruzi alditol amino acid antigen carbohydrate glycoconjugate glycoprotein lactose mucin phospholipid protein sialic acid derivative sialidase membrane protein binding site carbohydrate analysis catalysis cell surface genetic variability glycobiology insect life cycle nonhuman parasite priority journal review sialylation Trypanosoma cruzi animal biosynthesis chemistry growth, development and aging immunology metabolism molecular genetics Mammalia Trypanosoma cruzi Animals Carbohydrate Sequence Glycoconjugates Glycomics Life Cycle Stages Membrane Glycoproteins Molecular Sequence Data Trypanosoma cruzi The glycobiology of Trypanosoma cruzi, the causative agent of Chagas' disease, has contributed significantly to the identification of target enzymes responsible for the construction of unique cell-surface molecules. The authors discuss the structure of glycoinositolphospholipids, both free and as protein anchors in T. cruzi. The presence is emphasized of structural motifs that are absent in mammals. These include galactofuranose, aminoethylphosphonic acid, and inositolphosphoceramide. The mucins and the trans-sialidase (TcTS), both of which are involved in the infection process, are reviewed in detail in this chapter. The chemical synthesis of the oligosaccharides containing Galf is presented, as well as the use of the TcTS for synthetic purposes. © 2009 Elsevier Inc. All rights reserved. Fil:de Lederkremer, R.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Agusti, R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2009 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00652318_v62_n_p311_deLederkremer http://hdl.handle.net/20.500.12110/paper_00652318_v62_n_p311_deLederkremer
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Chagas' disease Galactofuranose Glycoinositolphospholipids GPI anchors Inositolphosphoceramide Mucins trans-Sialidase Trypanosoma cruzi alditol amino acid antigen carbohydrate glycoconjugate glycoprotein lactose mucin phospholipid protein sialic acid derivative sialidase membrane protein binding site carbohydrate analysis catalysis cell surface genetic variability glycobiology insect life cycle nonhuman parasite priority journal review sialylation Trypanosoma cruzi animal biosynthesis chemistry growth, development and aging immunology metabolism molecular genetics Mammalia Trypanosoma cruzi Animals Carbohydrate Sequence Glycoconjugates Glycomics Life Cycle Stages Membrane Glycoproteins Molecular Sequence Data Trypanosoma cruzi
spellingShingle	Chagas' disease Galactofuranose Glycoinositolphospholipids GPI anchors Inositolphosphoceramide Mucins trans-Sialidase Trypanosoma cruzi alditol amino acid antigen carbohydrate glycoconjugate glycoprotein lactose mucin phospholipid protein sialic acid derivative sialidase membrane protein binding site carbohydrate analysis catalysis cell surface genetic variability glycobiology insect life cycle nonhuman parasite priority journal review sialylation Trypanosoma cruzi animal biosynthesis chemistry growth, development and aging immunology metabolism molecular genetics Mammalia Trypanosoma cruzi Animals Carbohydrate Sequence Glycoconjugates Glycomics Life Cycle Stages Membrane Glycoproteins Molecular Sequence Data Trypanosoma cruzi Muchnik de Lederkremer, Rosa María Agustí, Rosalía Chapter 7 Glycobiology of Trypanosoma cruzi
topic_facet	Chagas' disease Galactofuranose Glycoinositolphospholipids GPI anchors Inositolphosphoceramide Mucins trans-Sialidase Trypanosoma cruzi alditol amino acid antigen carbohydrate glycoconjugate glycoprotein lactose mucin phospholipid protein sialic acid derivative sialidase membrane protein binding site carbohydrate analysis catalysis cell surface genetic variability glycobiology insect life cycle nonhuman parasite priority journal review sialylation Trypanosoma cruzi animal biosynthesis chemistry growth, development and aging immunology metabolism molecular genetics Mammalia Trypanosoma cruzi Animals Carbohydrate Sequence Glycoconjugates Glycomics Life Cycle Stages Membrane Glycoproteins Molecular Sequence Data Trypanosoma cruzi
description	The glycobiology of Trypanosoma cruzi, the causative agent of Chagas' disease, has contributed significantly to the identification of target enzymes responsible for the construction of unique cell-surface molecules. The authors discuss the structure of glycoinositolphospholipids, both free and as protein anchors in T. cruzi. The presence is emphasized of structural motifs that are absent in mammals. These include galactofuranose, aminoethylphosphonic acid, and inositolphosphoceramide. The mucins and the trans-sialidase (TcTS), both of which are involved in the infection process, are reviewed in detail in this chapter. The chemical synthesis of the oligosaccharides containing Galf is presented, as well as the use of the TcTS for synthetic purposes. © 2009 Elsevier Inc. All rights reserved.
author	Muchnik de Lederkremer, Rosa María Agustí, Rosalía
author_facet	Muchnik de Lederkremer, Rosa María Agustí, Rosalía
author_sort	Muchnik de Lederkremer, Rosa María
title	Chapter 7 Glycobiology of Trypanosoma cruzi
title_short	Chapter 7 Glycobiology of Trypanosoma cruzi
title_full	Chapter 7 Glycobiology of Trypanosoma cruzi
title_fullStr	Chapter 7 Glycobiology of Trypanosoma cruzi
title_full_unstemmed	Chapter 7 Glycobiology of Trypanosoma cruzi
title_sort	chapter 7 glycobiology of trypanosoma cruzi
publishDate	2009
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00652318_v62_n_p311_deLederkremer http://hdl.handle.net/20.500.12110/paper_00652318_v62_n_p311_deLederkremer
work_keys_str_mv	AT muchnikdelederkremerrosamaria chapter7glycobiologyoftrypanosomacruzi AT agustirosalia chapter7glycobiologyoftrypanosomacruzi
_version_	1768542880620609536

Chapter 7 Glycobiology of Trypanosoma cruzi

Ejemplares similares