Severe hemorrhagic tendency in heterozygous α2-antiplasmin deficiency

We report a case of partial deficiency of α2-antiplasmin. A 45 year old Spanish man had a life long severe bleeding tendency after trauma. Routine coagulation and platelet functional tests in symptomatic and asymptomatic periods were normal. During the bleeding there was a rapid whole blood clot lys...

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Guardado en:
Detalles Bibliográficos
Publicado: 1985
Materias:
Hemorrhagic tendency
Heterozygous
α2-Antiplasmin deficiency
alpha 2 antiplasmin
bleeding disorder
blood and hemopoietic system
case report
enzyme deficiency
fibrinolysis
human
priority journal
Antiplasmin
Blood Coagulation Factors
Blood Coagulation Tests
Case Report
Fibrinolysis
Hemorrhage
Heterozygote
Human
Male
Middle Age
Platelet Count
Platelet Function Tests
Reference Values
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00493848_v40_n5_p645_Kordich
http://hdl.handle.net/20.500.12110/paper_00493848_v40_n5_p645_Kordich
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:We report a case of partial deficiency of α2-antiplasmin. A 45 year old Spanish man had a life long severe bleeding tendency after trauma. Routine coagulation and platelet functional tests in symptomatic and asymptomatic periods were normal. During the bleeding there was a rapid whole blood clot lysis and the concentration of α2-antiplasmin in plasma was 20 to 25 % of normal controls. After recovery these levels showed a slight increase (35 to 45 % of normal). Addition of normal plasma to the patient's plasma increased α2-plasmin inhibitor activity. Bidimensional electrophoresis of α2-antiplasmin in the patient's plasma showed a normal pattern. Family studies showed that one of the proband'R two sons had a mild hemorrhagic tendency and 140 % of functional and antigenic levels of α2-antiplasmin. © 1985.

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