Severe hemorrhagic tendency in heterozygous α2-antiplasmin deficiency
We report a case of partial deficiency of α2-antiplasmin. A 45 year old Spanish man had a life long severe bleeding tendency after trauma. Routine coagulation and platelet functional tests in symptomatic and asymptomatic periods were normal. During the bleeding there was a rapid whole blood clot lys...
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1985
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00493848_v40_n5_p645_Kordich http://hdl.handle.net/20.500.12110/paper_00493848_v40_n5_p645_Kordich |
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paper:paper_00493848_v40_n5_p645_Kordich2023-06-08T15:05:48Z Severe hemorrhagic tendency in heterozygous α2-antiplasmin deficiency Hemorrhagic tendency Heterozygous α2-Antiplasmin deficiency alpha 2 antiplasmin bleeding disorder blood and hemopoietic system case report enzyme deficiency fibrinolysis human priority journal Antiplasmin Blood Coagulation Factors Blood Coagulation Tests Case Report Fibrinolysis Hemorrhage Heterozygote Human Male Middle Age Platelet Count Platelet Function Tests Reference Values We report a case of partial deficiency of α2-antiplasmin. A 45 year old Spanish man had a life long severe bleeding tendency after trauma. Routine coagulation and platelet functional tests in symptomatic and asymptomatic periods were normal. During the bleeding there was a rapid whole blood clot lysis and the concentration of α2-antiplasmin in plasma was 20 to 25 % of normal controls. After recovery these levels showed a slight increase (35 to 45 % of normal). Addition of normal plasma to the patient's plasma increased α2-plasmin inhibitor activity. Bidimensional electrophoresis of α2-antiplasmin in the patient's plasma showed a normal pattern. Family studies showed that one of the proband'R two sons had a mild hemorrhagic tendency and 140 % of functional and antigenic levels of α2-antiplasmin. © 1985. 1985 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00493848_v40_n5_p645_Kordich http://hdl.handle.net/20.500.12110/paper_00493848_v40_n5_p645_Kordich |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Hemorrhagic tendency Heterozygous α2-Antiplasmin deficiency alpha 2 antiplasmin bleeding disorder blood and hemopoietic system case report enzyme deficiency fibrinolysis human priority journal Antiplasmin Blood Coagulation Factors Blood Coagulation Tests Case Report Fibrinolysis Hemorrhage Heterozygote Human Male Middle Age Platelet Count Platelet Function Tests Reference Values |
| spellingShingle |
Hemorrhagic tendency Heterozygous α2-Antiplasmin deficiency alpha 2 antiplasmin bleeding disorder blood and hemopoietic system case report enzyme deficiency fibrinolysis human priority journal Antiplasmin Blood Coagulation Factors Blood Coagulation Tests Case Report Fibrinolysis Hemorrhage Heterozygote Human Male Middle Age Platelet Count Platelet Function Tests Reference Values Severe hemorrhagic tendency in heterozygous α2-antiplasmin deficiency |
| topic_facet |
Hemorrhagic tendency Heterozygous α2-Antiplasmin deficiency alpha 2 antiplasmin bleeding disorder blood and hemopoietic system case report enzyme deficiency fibrinolysis human priority journal Antiplasmin Blood Coagulation Factors Blood Coagulation Tests Case Report Fibrinolysis Hemorrhage Heterozygote Human Male Middle Age Platelet Count Platelet Function Tests Reference Values |
| description |
We report a case of partial deficiency of α2-antiplasmin. A 45 year old Spanish man had a life long severe bleeding tendency after trauma. Routine coagulation and platelet functional tests in symptomatic and asymptomatic periods were normal. During the bleeding there was a rapid whole blood clot lysis and the concentration of α2-antiplasmin in plasma was 20 to 25 % of normal controls. After recovery these levels showed a slight increase (35 to 45 % of normal). Addition of normal plasma to the patient's plasma increased α2-plasmin inhibitor activity. Bidimensional electrophoresis of α2-antiplasmin in the patient's plasma showed a normal pattern. Family studies showed that one of the proband'R two sons had a mild hemorrhagic tendency and 140 % of functional and antigenic levels of α2-antiplasmin. © 1985. |
| title |
Severe hemorrhagic tendency in heterozygous α2-antiplasmin deficiency |
| title_short |
Severe hemorrhagic tendency in heterozygous α2-antiplasmin deficiency |
| title_full |
Severe hemorrhagic tendency in heterozygous α2-antiplasmin deficiency |
| title_fullStr |
Severe hemorrhagic tendency in heterozygous α2-antiplasmin deficiency |
| title_full_unstemmed |
Severe hemorrhagic tendency in heterozygous α2-antiplasmin deficiency |
| title_sort |
severe hemorrhagic tendency in heterozygous α2-antiplasmin deficiency |
| publishDate |
1985 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00493848_v40_n5_p645_Kordich http://hdl.handle.net/20.500.12110/paper_00493848_v40_n5_p645_Kordich |
| _version_ |
1768546107912093696 |