The SSRI fluoxetine exhibits mild effects on the reproductive axis in the cichlid fish Cichlasoma dimerus (Teleostei, Cichliformes)

Among the wide variety of pharmaceuticals released into the environment, Fluoxetine (FLX), a selective serotonin reuptake inhibitor, is one of the most prescribed for the treatment of major depression. It inhibits serotonin (5-HT) reuptake at the presinaptic membrane, increasing serotonergic activit...

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Autores principales:	Da Cuña, Rodrigo Hernán, Rey Vázquez, Graciela, Genovese, Griselda, Lo Nostro, Fabiana Laura
Publicado:	2017
Materias:	Contaminants of emerging concern Endocrine disruption Gonadotrophins Pharmaceuticals Reproduction Serotonin Controlled drug delivery Drug products Fish Physiology Contaminants of emerging concerns Endocrine disrupters alcian blue estradiol fluoxetine follitropin beta subunit luteinizing hormone beta subunit sodium chloride testosterone vitellogenin endocrine disruptor serotonin uptake inhibitor steroid water pollutant chemical compound cichlid drug hormone inhibitor physiology pollutant protein reproduction adult animal experiment animal tissue Article Cichlasoma dimerus controlled study estradiol blood level female foam cell follitropin blood level hypophysis luteinizing hormone blood level male Neotropics nonhuman ovary tissue reproductive toxicity serotoninergic system testosterone blood level animal drug effects ecotoxicology metabolism toxicity Cichlasoma Cichlidae Teleostei Vertebrata Animals Cichlids Ecotoxicology Endocrine Disruptors Female Fluoxetine Male Pituitary Gland Serotonin Uptake Inhibitors Steroids Water Pollutants, Chemical
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00456535_v171_n_p370_Dorelle http://hdl.handle.net/20.500.12110/paper_00456535_v171_n_p370_Dorelle
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00456535_v171_n_p370_Dorelle
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spelling	paper:paper_00456535_v171_n_p370_Dorelle2023-06-08T15:05:16Z The SSRI fluoxetine exhibits mild effects on the reproductive axis in the cichlid fish Cichlasoma dimerus (Teleostei, Cichliformes) Da Cuña, Rodrigo Hernán Rey Vázquez, Graciela Genovese, Griselda Lo Nostro, Fabiana Laura Contaminants of emerging concern Endocrine disruption Gonadotrophins Pharmaceuticals Reproduction Serotonin Controlled drug delivery Drug products Fish Physiology Contaminants of emerging concerns Endocrine disruption Gonadotrophins Reproduction Serotonin Endocrine disrupters alcian blue estradiol fluoxetine follitropin beta subunit luteinizing hormone beta subunit sodium chloride testosterone vitellogenin endocrine disruptor fluoxetine serotonin uptake inhibitor steroid water pollutant chemical compound cichlid drug endocrine disruptor hormone inhibitor physiology pollutant protein reproduction steroid adult animal experiment animal tissue Article Cichlasoma dimerus cichlid controlled study estradiol blood level female foam cell follitropin blood level hypophysis luteinizing hormone blood level male Neotropics nonhuman ovary tissue reproduction reproductive toxicity serotoninergic system testosterone blood level animal cichlid drug effects ecotoxicology metabolism physiology reproduction toxicity water pollutant Cichlasoma Cichlidae Teleostei Vertebrata Animals Cichlids Ecotoxicology Endocrine Disruptors Female Fluoxetine Male Pituitary Gland Reproduction Serotonin Uptake Inhibitors Steroids Water Pollutants, Chemical Among the wide variety of pharmaceuticals released into the environment, Fluoxetine (FLX), a selective serotonin reuptake inhibitor, is one of the most prescribed for the treatment of major depression. It inhibits serotonin (5-HT) reuptake at the presinaptic membrane, increasing serotonergic activity. In vertebrates, including fish, the serotonergic system is closely related to the Hypothalamic Pituitary Gonadal (HPG) axis which regulates reproduction. As FLX can act as an endocrine disrupting compound (EDC) by affecting several reproductive parameters in fish, the aim of this study was to provide an integral assessment of the potential effect of FLX on the reproductive axis of the Neotropical freshwater fish Cichlasoma dimerus. Adult fish were intraperitoneally injected with 2 μg g−1FLX or saline every third day for 15 days. No significant differences were found on serotonergic turnover (5-HIAA/5-HT ratio). Pituitary βLH content in FLX injected females was significantly higher than control females; no significant differences were seen for βFSH content. Sex steroids remained unaltered, both in males and females fish, after FLX treatment. No plasma vitellogenin was induced in treated males. Some alterations were seen in testes of FLX injected males, such as the presence of foam cells and an acidophilic PAS positive, Alcian-Blue negative secretion in the lobular lumen. Although there is no clear consensus about the effect of this drug on reproductive physiology, these results indicate that FLX is acting as a mild EDC in adults of C. dimerus. © 2016 Elsevier Ltd Fil:Da Cuña, R.H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Rey Vázquez, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Genovese, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Lo Nostro, F.L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2017 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00456535_v171_n_p370_Dorelle http://hdl.handle.net/20.500.12110/paper_00456535_v171_n_p370_Dorelle
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Contaminants of emerging concern Endocrine disruption Gonadotrophins Pharmaceuticals Reproduction Serotonin Controlled drug delivery Drug products Fish Physiology Contaminants of emerging concerns Endocrine disruption Gonadotrophins Reproduction Serotonin Endocrine disrupters alcian blue estradiol fluoxetine follitropin beta subunit luteinizing hormone beta subunit sodium chloride testosterone vitellogenin endocrine disruptor fluoxetine serotonin uptake inhibitor steroid water pollutant chemical compound cichlid drug endocrine disruptor hormone inhibitor physiology pollutant protein reproduction steroid adult animal experiment animal tissue Article Cichlasoma dimerus cichlid controlled study estradiol blood level female foam cell follitropin blood level hypophysis luteinizing hormone blood level male Neotropics nonhuman ovary tissue reproduction reproductive toxicity serotoninergic system testosterone blood level animal cichlid drug effects ecotoxicology metabolism physiology reproduction toxicity water pollutant Cichlasoma Cichlidae Teleostei Vertebrata Animals Cichlids Ecotoxicology Endocrine Disruptors Female Fluoxetine Male Pituitary Gland Reproduction Serotonin Uptake Inhibitors Steroids Water Pollutants, Chemical
spellingShingle	Contaminants of emerging concern Endocrine disruption Gonadotrophins Pharmaceuticals Reproduction Serotonin Controlled drug delivery Drug products Fish Physiology Contaminants of emerging concerns Endocrine disruption Gonadotrophins Reproduction Serotonin Endocrine disrupters alcian blue estradiol fluoxetine follitropin beta subunit luteinizing hormone beta subunit sodium chloride testosterone vitellogenin endocrine disruptor fluoxetine serotonin uptake inhibitor steroid water pollutant chemical compound cichlid drug endocrine disruptor hormone inhibitor physiology pollutant protein reproduction steroid adult animal experiment animal tissue Article Cichlasoma dimerus cichlid controlled study estradiol blood level female foam cell follitropin blood level hypophysis luteinizing hormone blood level male Neotropics nonhuman ovary tissue reproduction reproductive toxicity serotoninergic system testosterone blood level animal cichlid drug effects ecotoxicology metabolism physiology reproduction toxicity water pollutant Cichlasoma Cichlidae Teleostei Vertebrata Animals Cichlids Ecotoxicology Endocrine Disruptors Female Fluoxetine Male Pituitary Gland Reproduction Serotonin Uptake Inhibitors Steroids Water Pollutants, Chemical Da Cuña, Rodrigo Hernán Rey Vázquez, Graciela Genovese, Griselda Lo Nostro, Fabiana Laura The SSRI fluoxetine exhibits mild effects on the reproductive axis in the cichlid fish Cichlasoma dimerus (Teleostei, Cichliformes)
topic_facet	Contaminants of emerging concern Endocrine disruption Gonadotrophins Pharmaceuticals Reproduction Serotonin Controlled drug delivery Drug products Fish Physiology Contaminants of emerging concerns Endocrine disruption Gonadotrophins Reproduction Serotonin Endocrine disrupters alcian blue estradiol fluoxetine follitropin beta subunit luteinizing hormone beta subunit sodium chloride testosterone vitellogenin endocrine disruptor fluoxetine serotonin uptake inhibitor steroid water pollutant chemical compound cichlid drug endocrine disruptor hormone inhibitor physiology pollutant protein reproduction steroid adult animal experiment animal tissue Article Cichlasoma dimerus cichlid controlled study estradiol blood level female foam cell follitropin blood level hypophysis luteinizing hormone blood level male Neotropics nonhuman ovary tissue reproduction reproductive toxicity serotoninergic system testosterone blood level animal cichlid drug effects ecotoxicology metabolism physiology reproduction toxicity water pollutant Cichlasoma Cichlidae Teleostei Vertebrata Animals Cichlids Ecotoxicology Endocrine Disruptors Female Fluoxetine Male Pituitary Gland Reproduction Serotonin Uptake Inhibitors Steroids Water Pollutants, Chemical
description	Among the wide variety of pharmaceuticals released into the environment, Fluoxetine (FLX), a selective serotonin reuptake inhibitor, is one of the most prescribed for the treatment of major depression. It inhibits serotonin (5-HT) reuptake at the presinaptic membrane, increasing serotonergic activity. In vertebrates, including fish, the serotonergic system is closely related to the Hypothalamic Pituitary Gonadal (HPG) axis which regulates reproduction. As FLX can act as an endocrine disrupting compound (EDC) by affecting several reproductive parameters in fish, the aim of this study was to provide an integral assessment of the potential effect of FLX on the reproductive axis of the Neotropical freshwater fish Cichlasoma dimerus. Adult fish were intraperitoneally injected with 2 μg g−1FLX or saline every third day for 15 days. No significant differences were found on serotonergic turnover (5-HIAA/5-HT ratio). Pituitary βLH content in FLX injected females was significantly higher than control females; no significant differences were seen for βFSH content. Sex steroids remained unaltered, both in males and females fish, after FLX treatment. No plasma vitellogenin was induced in treated males. Some alterations were seen in testes of FLX injected males, such as the presence of foam cells and an acidophilic PAS positive, Alcian-Blue negative secretion in the lobular lumen. Although there is no clear consensus about the effect of this drug on reproductive physiology, these results indicate that FLX is acting as a mild EDC in adults of C. dimerus. © 2016 Elsevier Ltd
author	Da Cuña, Rodrigo Hernán Rey Vázquez, Graciela Genovese, Griselda Lo Nostro, Fabiana Laura
author_facet	Da Cuña, Rodrigo Hernán Rey Vázquez, Graciela Genovese, Griselda Lo Nostro, Fabiana Laura
author_sort	Da Cuña, Rodrigo Hernán
title	The SSRI fluoxetine exhibits mild effects on the reproductive axis in the cichlid fish Cichlasoma dimerus (Teleostei, Cichliformes)
title_short	The SSRI fluoxetine exhibits mild effects on the reproductive axis in the cichlid fish Cichlasoma dimerus (Teleostei, Cichliformes)
title_full	The SSRI fluoxetine exhibits mild effects on the reproductive axis in the cichlid fish Cichlasoma dimerus (Teleostei, Cichliformes)
title_fullStr	The SSRI fluoxetine exhibits mild effects on the reproductive axis in the cichlid fish Cichlasoma dimerus (Teleostei, Cichliformes)
title_full_unstemmed	The SSRI fluoxetine exhibits mild effects on the reproductive axis in the cichlid fish Cichlasoma dimerus (Teleostei, Cichliformes)
title_sort	ssri fluoxetine exhibits mild effects on the reproductive axis in the cichlid fish cichlasoma dimerus (teleostei, cichliformes)
publishDate	2017
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00456535_v171_n_p370_Dorelle http://hdl.handle.net/20.500.12110/paper_00456535_v171_n_p370_Dorelle
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The SSRI fluoxetine exhibits mild effects on the reproductive axis in the cichlid fish Cichlasoma dimerus (Teleostei, Cichliformes)

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