Synthesis of C-C bonded dimeric steroids by olefin metathesis

Five new C-C bonded steroidal homodimers derived from deoxycholic acid, pregnenolone, and progesterone were synthesized by an olefin metathesis reaction assisted by microwave heating. Microwave improved the yield and accelerated the reaction allowing the use of less catalyst with good results (2.5 m...

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Autores principales:	Edelsztein, Valeria Carolina, Di Chenna, Pablo Héctor, Burton, Gerardo
Publicado:	2009
Materias:	Dimeric steroids Dimerization Metathesis Microwave alkene deoxycholic acid isomerase pregnenolone progesterone steroid article chemical reaction chemical structure dimerization hydrogen bond microwave cooking priority journal ring closing metathesis synthesis
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00404020_v65_n18_p3615_Edelsztein http://hdl.handle.net/20.500.12110/paper_00404020_v65_n18_p3615_Edelsztein
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00404020_v65_n18_p3615_Edelsztein
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spelling	paper:paper_00404020_v65_n18_p3615_Edelsztein2023-06-08T15:04:18Z Synthesis of C-C bonded dimeric steroids by olefin metathesis Edelsztein, Valeria Carolina Di Chenna, Pablo Héctor Burton, Gerardo Dimeric steroids Dimerization Metathesis Microwave alkene deoxycholic acid isomerase pregnenolone progesterone steroid article chemical reaction chemical structure dimerization hydrogen bond microwave cooking priority journal ring closing metathesis synthesis Five new C-C bonded steroidal homodimers derived from deoxycholic acid, pregnenolone, and progesterone were synthesized by an olefin metathesis reaction assisted by microwave heating. Microwave improved the yield and accelerated the reaction allowing the use of less catalyst with good results (2.5 mol %). Due to the bulky nature of the steroidal skeleton the more favorable E-dimers were formed as the sole or major products depending on the linker length. © 2009 Elsevier Ltd. All rights reserved. Fil:Edelsztein, V.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Di Chenna, P.H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Burton, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2009 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00404020_v65_n18_p3615_Edelsztein http://hdl.handle.net/20.500.12110/paper_00404020_v65_n18_p3615_Edelsztein
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Dimeric steroids Dimerization Metathesis Microwave alkene deoxycholic acid isomerase pregnenolone progesterone steroid article chemical reaction chemical structure dimerization hydrogen bond microwave cooking priority journal ring closing metathesis synthesis
spellingShingle	Dimeric steroids Dimerization Metathesis Microwave alkene deoxycholic acid isomerase pregnenolone progesterone steroid article chemical reaction chemical structure dimerization hydrogen bond microwave cooking priority journal ring closing metathesis synthesis Edelsztein, Valeria Carolina Di Chenna, Pablo Héctor Burton, Gerardo Synthesis of C-C bonded dimeric steroids by olefin metathesis
topic_facet	Dimeric steroids Dimerization Metathesis Microwave alkene deoxycholic acid isomerase pregnenolone progesterone steroid article chemical reaction chemical structure dimerization hydrogen bond microwave cooking priority journal ring closing metathesis synthesis
description	Five new C-C bonded steroidal homodimers derived from deoxycholic acid, pregnenolone, and progesterone were synthesized by an olefin metathesis reaction assisted by microwave heating. Microwave improved the yield and accelerated the reaction allowing the use of less catalyst with good results (2.5 mol %). Due to the bulky nature of the steroidal skeleton the more favorable E-dimers were formed as the sole or major products depending on the linker length. © 2009 Elsevier Ltd. All rights reserved.
author	Edelsztein, Valeria Carolina Di Chenna, Pablo Héctor Burton, Gerardo
author_facet	Edelsztein, Valeria Carolina Di Chenna, Pablo Héctor Burton, Gerardo
author_sort	Edelsztein, Valeria Carolina
title	Synthesis of C-C bonded dimeric steroids by olefin metathesis
title_short	Synthesis of C-C bonded dimeric steroids by olefin metathesis
title_full	Synthesis of C-C bonded dimeric steroids by olefin metathesis
title_fullStr	Synthesis of C-C bonded dimeric steroids by olefin metathesis
title_full_unstemmed	Synthesis of C-C bonded dimeric steroids by olefin metathesis
title_sort	synthesis of c-c bonded dimeric steroids by olefin metathesis
publishDate	2009
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00404020_v65_n18_p3615_Edelsztein http://hdl.handle.net/20.500.12110/paper_00404020_v65_n18_p3615_Edelsztein
work_keys_str_mv	AT edelszteinvaleriacarolina synthesisofccbondeddimericsteroidsbyolefinmetathesis AT dichennapablohector synthesisofccbondeddimericsteroidsbyolefinmetathesis AT burtongerardo synthesisofccbondeddimericsteroidsbyolefinmetathesis
_version_	1768544632027742208

Synthesis of C-C bonded dimeric steroids by olefin metathesis

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