Neuropsychological, psychiatric, and cerebral blood flow findings in vascular dementia and Alzheimer's disease

Background and Purpose: Psychiatric, neuropsychological, and cerebral blood flow differences between patients with ischemic vascular dementia (IVD) or Alzheimer's disease (AD) were examined. Methods: A consecutive series of patients who met either the criteria off the National Institute of Neur...

Descripción completa

Detalles Bibliográficos
Publicado:	1996
Materias:	Alzheimer's disease cerebral blood flow dementia neuropsychology aged anosognosia article brain blood flow cognitive defect depression disease association female human major clinical study male neuropsychological test priority journal rating scale single photon emission computer tomography
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00392499_v27_n3_p408_Starkstein http://hdl.handle.net/20.500.12110/paper_00392499_v27_n3_p408_Starkstein
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00392499_v27_n3_p408_Starkstein
record_format	dspace
spelling	paper:paper_00392499_v27_n3_p408_Starkstein2023-06-08T15:03:23Z Neuropsychological, psychiatric, and cerebral blood flow findings in vascular dementia and Alzheimer's disease Alzheimer's disease cerebral blood flow dementia neuropsychology aged anosognosia article brain blood flow cognitive defect dementia depression disease association female human major clinical study male neuropsychological test neuropsychology priority journal rating scale single photon emission computer tomography Background and Purpose: Psychiatric, neuropsychological, and cerebral blood flow differences between patients with ischemic vascular dementia (IVD) or Alzheimer's disease (AD) were examined. Methods: A consecutive series of patients who met either the criteria off the National Institute of Neurological Disorders Association for probable AD or the State of California AD Diagnostic and Treatment Centers criteria for probable IVD were included in the study. Twenty consecutive patients with IVD were matched for age, sex, and Mini-Mental State Examination scores with 40 consecutive patients with probable AD. Patients underwent a psychiatric interview, a neuropsychological assessment, and single-photon emission CT imaging with 99mTc- hexamethylpropyleneamine oxime. Results: Patients with IVD showed significantly more severe anosognosia (P<.05) and emotional lability (P<.01) than AD patients, but no significant between-group differences were found in the frequency and severity of depression. IVD patients showed significantly more severe deficits in tests of planning, sequencing (P<.05), and verbal fluency (P<.05) as well as significantly more severe cerebral blood flow deficits in the basal ganglia (P<.01) and the frontal lobes (P<.001) than AD patients. Conclusions: Patients with IVD showed a relatively more severe dysfunction of the frontal lobes as demonstrated by single-photon emission CT and expressed in specific psychiatric and neuropsychological changes that AD patients matched for age, sex, and severity of dementia. 1996 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00392499_v27_n3_p408_Starkstein http://hdl.handle.net/20.500.12110/paper_00392499_v27_n3_p408_Starkstein
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Alzheimer's disease cerebral blood flow dementia neuropsychology aged anosognosia article brain blood flow cognitive defect dementia depression disease association female human major clinical study male neuropsychological test neuropsychology priority journal rating scale single photon emission computer tomography
spellingShingle	Alzheimer's disease cerebral blood flow dementia neuropsychology aged anosognosia article brain blood flow cognitive defect dementia depression disease association female human major clinical study male neuropsychological test neuropsychology priority journal rating scale single photon emission computer tomography Neuropsychological, psychiatric, and cerebral blood flow findings in vascular dementia and Alzheimer's disease
topic_facet	Alzheimer's disease cerebral blood flow dementia neuropsychology aged anosognosia article brain blood flow cognitive defect dementia depression disease association female human major clinical study male neuropsychological test neuropsychology priority journal rating scale single photon emission computer tomography
description	Background and Purpose: Psychiatric, neuropsychological, and cerebral blood flow differences between patients with ischemic vascular dementia (IVD) or Alzheimer's disease (AD) were examined. Methods: A consecutive series of patients who met either the criteria off the National Institute of Neurological Disorders Association for probable AD or the State of California AD Diagnostic and Treatment Centers criteria for probable IVD were included in the study. Twenty consecutive patients with IVD were matched for age, sex, and Mini-Mental State Examination scores with 40 consecutive patients with probable AD. Patients underwent a psychiatric interview, a neuropsychological assessment, and single-photon emission CT imaging with 99mTc- hexamethylpropyleneamine oxime. Results: Patients with IVD showed significantly more severe anosognosia (P<.05) and emotional lability (P<.01) than AD patients, but no significant between-group differences were found in the frequency and severity of depression. IVD patients showed significantly more severe deficits in tests of planning, sequencing (P<.05), and verbal fluency (P<.05) as well as significantly more severe cerebral blood flow deficits in the basal ganglia (P<.01) and the frontal lobes (P<.001) than AD patients. Conclusions: Patients with IVD showed a relatively more severe dysfunction of the frontal lobes as demonstrated by single-photon emission CT and expressed in specific psychiatric and neuropsychological changes that AD patients matched for age, sex, and severity of dementia.
title	Neuropsychological, psychiatric, and cerebral blood flow findings in vascular dementia and Alzheimer's disease
title_short	Neuropsychological, psychiatric, and cerebral blood flow findings in vascular dementia and Alzheimer's disease
title_full	Neuropsychological, psychiatric, and cerebral blood flow findings in vascular dementia and Alzheimer's disease
title_fullStr	Neuropsychological, psychiatric, and cerebral blood flow findings in vascular dementia and Alzheimer's disease
title_full_unstemmed	Neuropsychological, psychiatric, and cerebral blood flow findings in vascular dementia and Alzheimer's disease
title_sort	neuropsychological, psychiatric, and cerebral blood flow findings in vascular dementia and alzheimer's disease
publishDate	1996
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00392499_v27_n3_p408_Starkstein http://hdl.handle.net/20.500.12110/paper_00392499_v27_n3_p408_Starkstein
_version_	1768542026731618304

Neuropsychological, psychiatric, and cerebral blood flow findings in vascular dementia and Alzheimer's disease

Ejemplares similares