Heme availability affects corticosterone and aldosterone biosynthesis in rat adrenal

In this paper, we studied the effect of heme availability on corticosterone and aldosterone synthesis in rat adrenal. We found that hemin stimulated corticosterone and aldosterone production in adrenal homogenates in a dose-dependent fashion. Hemin administration to rats also provoked an increase in...

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Autores principales:	Martini, Claudia Noemí, Romero, Damián Gastón, Vila, María del Carmen
Publicado:	1997
Materias:	3.5-diethoxycarbonyl-1,4- dihydro-2,4,6-trimethylpyridine (DDC) Aldosterone Biosynthesis Corticosterone Heme Rat adrenal 1,4 dihydro 2,4,6 trimethyl 3,5 pyridinedicarboxylic acid diethyl ester aldosterone catalase corticosterone heme hemin porphyrin adrenal gland animal tissue article controlled study heme synthesis hormonal regulation hormone synthesis liver male nonhuman rat 5-Aminolevulinate Synthetase Adrenal Glands Adrenocorticotropic Hormone Animals Desoxycorticosterone Dicarbethoxydihydrocollidine Ferrochelatase Hemin Liver Male Porphyrins Rats Rats, Sprague-Dawley
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0039128X_v62_n12_p767_Martini http://hdl.handle.net/20.500.12110/paper_0039128X_v62_n12_p767_Martini
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_0039128X_v62_n12_p767_Martini
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spelling	paper:paper_0039128X_v62_n12_p767_Martini2023-06-08T15:03:16Z Heme availability affects corticosterone and aldosterone biosynthesis in rat adrenal Martini, Claudia Noemí Romero, Damián Gastón Vila, María del Carmen 3.5-diethoxycarbonyl-1,4- dihydro-2,4,6-trimethylpyridine (DDC) Aldosterone Biosynthesis Corticosterone Heme Rat adrenal 1,4 dihydro 2,4,6 trimethyl 3,5 pyridinedicarboxylic acid diethyl ester aldosterone catalase corticosterone heme hemin porphyrin adrenal gland animal tissue article controlled study heme synthesis hormonal regulation hormone synthesis liver male nonhuman rat 5-Aminolevulinate Synthetase Adrenal Glands Adrenocorticotropic Hormone Aldosterone Animals Corticosterone Desoxycorticosterone Dicarbethoxydihydrocollidine Ferrochelatase Heme Hemin Liver Male Porphyrins Rats Rats, Sprague-Dawley In this paper, we studied the effect of heme availability on corticosterone and aldosterone synthesis in rat adrenal. We found that hemin stimulated corticosterone and aldosterone production in adrenal homogenates in a dose-dependent fashion. Hemin administration to rats also provoked an increase in both corticosterone and aldosterone content in adrenal. 3.5- Diethoxycarbonyl-1.4-dihydro-2,4,6-trimethylpyridine (DDC), an inhibitor of liver ferrochelatase activity, was able to inhibit this enzyme in rat adrenal. This resulted in an impairment of heme concentration and consequently adrenal ALA-synthase and porphyrin content were increased. Thus, it was proven that DDC inhibits heme biosynthesis in adrenal as it does in liver. In vivo experiments with rats showed that DDC was able to partially blocked ACTH-mediated corticosterone and aldosterone production while heroin administration was able to partially restore it. These data indicate that heme availability affects steroid biosynthesis in rat adrenal. Fil:Martini, C.N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Romero, D.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Vila, M.D.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1997 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0039128X_v62_n12_p767_Martini http://hdl.handle.net/20.500.12110/paper_0039128X_v62_n12_p767_Martini
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	3.5-diethoxycarbonyl-1,4- dihydro-2,4,6-trimethylpyridine (DDC) Aldosterone Biosynthesis Corticosterone Heme Rat adrenal 1,4 dihydro 2,4,6 trimethyl 3,5 pyridinedicarboxylic acid diethyl ester aldosterone catalase corticosterone heme hemin porphyrin adrenal gland animal tissue article controlled study heme synthesis hormonal regulation hormone synthesis liver male nonhuman rat 5-Aminolevulinate Synthetase Adrenal Glands Adrenocorticotropic Hormone Aldosterone Animals Corticosterone Desoxycorticosterone Dicarbethoxydihydrocollidine Ferrochelatase Heme Hemin Liver Male Porphyrins Rats Rats, Sprague-Dawley
spellingShingle	3.5-diethoxycarbonyl-1,4- dihydro-2,4,6-trimethylpyridine (DDC) Aldosterone Biosynthesis Corticosterone Heme Rat adrenal 1,4 dihydro 2,4,6 trimethyl 3,5 pyridinedicarboxylic acid diethyl ester aldosterone catalase corticosterone heme hemin porphyrin adrenal gland animal tissue article controlled study heme synthesis hormonal regulation hormone synthesis liver male nonhuman rat 5-Aminolevulinate Synthetase Adrenal Glands Adrenocorticotropic Hormone Aldosterone Animals Corticosterone Desoxycorticosterone Dicarbethoxydihydrocollidine Ferrochelatase Heme Hemin Liver Male Porphyrins Rats Rats, Sprague-Dawley Martini, Claudia Noemí Romero, Damián Gastón Vila, María del Carmen Heme availability affects corticosterone and aldosterone biosynthesis in rat adrenal
topic_facet	3.5-diethoxycarbonyl-1,4- dihydro-2,4,6-trimethylpyridine (DDC) Aldosterone Biosynthesis Corticosterone Heme Rat adrenal 1,4 dihydro 2,4,6 trimethyl 3,5 pyridinedicarboxylic acid diethyl ester aldosterone catalase corticosterone heme hemin porphyrin adrenal gland animal tissue article controlled study heme synthesis hormonal regulation hormone synthesis liver male nonhuman rat 5-Aminolevulinate Synthetase Adrenal Glands Adrenocorticotropic Hormone Aldosterone Animals Corticosterone Desoxycorticosterone Dicarbethoxydihydrocollidine Ferrochelatase Heme Hemin Liver Male Porphyrins Rats Rats, Sprague-Dawley
description	In this paper, we studied the effect of heme availability on corticosterone and aldosterone synthesis in rat adrenal. We found that hemin stimulated corticosterone and aldosterone production in adrenal homogenates in a dose-dependent fashion. Hemin administration to rats also provoked an increase in both corticosterone and aldosterone content in adrenal. 3.5- Diethoxycarbonyl-1.4-dihydro-2,4,6-trimethylpyridine (DDC), an inhibitor of liver ferrochelatase activity, was able to inhibit this enzyme in rat adrenal. This resulted in an impairment of heme concentration and consequently adrenal ALA-synthase and porphyrin content were increased. Thus, it was proven that DDC inhibits heme biosynthesis in adrenal as it does in liver. In vivo experiments with rats showed that DDC was able to partially blocked ACTH-mediated corticosterone and aldosterone production while heroin administration was able to partially restore it. These data indicate that heme availability affects steroid biosynthesis in rat adrenal.
author	Martini, Claudia Noemí Romero, Damián Gastón Vila, María del Carmen
author_facet	Martini, Claudia Noemí Romero, Damián Gastón Vila, María del Carmen
author_sort	Martini, Claudia Noemí
title	Heme availability affects corticosterone and aldosterone biosynthesis in rat adrenal
title_short	Heme availability affects corticosterone and aldosterone biosynthesis in rat adrenal
title_full	Heme availability affects corticosterone and aldosterone biosynthesis in rat adrenal
title_fullStr	Heme availability affects corticosterone and aldosterone biosynthesis in rat adrenal
title_full_unstemmed	Heme availability affects corticosterone and aldosterone biosynthesis in rat adrenal
title_sort	heme availability affects corticosterone and aldosterone biosynthesis in rat adrenal
publishDate	1997
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0039128X_v62_n12_p767_Martini http://hdl.handle.net/20.500.12110/paper_0039128X_v62_n12_p767_Martini
work_keys_str_mv	AT martiniclaudianoemi hemeavailabilityaffectscorticosteroneandaldosteronebiosynthesisinratadrenal AT romerodamiangaston hemeavailabilityaffectscorticosteroneandaldosteronebiosynthesisinratadrenal AT vilamariadelcarmen hemeavailabilityaffectscorticosteroneandaldosteronebiosynthesisinratadrenal
_version_	1768543459540467712

Heme availability affects corticosterone and aldosterone biosynthesis in rat adrenal

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