Stimulation of aldosterone production by hemin in calf adrenal glomerulosa cell cultures

Aldosterone production from 11-deoxycorticosterone was stimulated by hemin in primary cultures and homogenates of calf adrenal zona glomerulosa, in a time- and dose-dependent fashion. The ferrochelatase inhibitor 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) blocked the stimulation...

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Autores principales:	Cozza, Eduardo Néstor, Vila, María del Carmen
Publicado:	1993
Materias:	aldosterone stimulation, hemin hemin, aldosterone stimulation 1,4 dihydro 2,4,6 trimethyl 3,5 pyridinedicarboxylic acid diethyl ester aldosterone corticotropin cytochrome p450 hemin adrenal cell aldosterone release animal cell cattle cell culture conference paper controlled study dose time effect relation enzyme activity incubation time liver metabolism metabolic regulation nonhuman steroidogenesis zona glomerulosa Aldosterone Animal Cattle Cells, Cultured Corticotropin Dicarbethoxydihydrocollidine Female Ferrochelatase Hemin Kinetics Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Zona Glomerulosa Animalia Bos taurus
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0039128X_v58_n8_p384_Cozza http://hdl.handle.net/20.500.12110/paper_0039128X_v58_n8_p384_Cozza
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_0039128X_v58_n8_p384_Cozza
record_format	dspace
spelling	paper:paper_0039128X_v58_n8_p384_Cozza2023-06-08T15:03:14Z Stimulation of aldosterone production by hemin in calf adrenal glomerulosa cell cultures Cozza, Eduardo Néstor Vila, María del Carmen aldosterone stimulation, hemin hemin, aldosterone stimulation 1,4 dihydro 2,4,6 trimethyl 3,5 pyridinedicarboxylic acid diethyl ester aldosterone corticotropin cytochrome p450 hemin adrenal cell aldosterone release animal cell cattle cell culture conference paper controlled study dose time effect relation enzyme activity incubation time liver metabolism metabolic regulation nonhuman steroidogenesis zona glomerulosa Aldosterone Animal Cattle Cells, Cultured Corticotropin Dicarbethoxydihydrocollidine Female Ferrochelatase Hemin Kinetics Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Zona Glomerulosa Animalia Bos taurus Aldosterone production from 11-deoxycorticosterone was stimulated by hemin in primary cultures and homogenates of calf adrenal zona glomerulosa, in a time- and dose-dependent fashion. The ferrochelatase inhibitor 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) blocked the stimulation of aldosterone mediated by adrenocorticotropin (ACTH). Addition of hemin after treatment with DDC partially restored ACTH action. These results suggest that hemin may play a role in regulation of aldosterone production. © 1993. Fil:Cozza, E.N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Vila, M.d.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1993 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0039128X_v58_n8_p384_Cozza http://hdl.handle.net/20.500.12110/paper_0039128X_v58_n8_p384_Cozza
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	aldosterone stimulation, hemin hemin, aldosterone stimulation 1,4 dihydro 2,4,6 trimethyl 3,5 pyridinedicarboxylic acid diethyl ester aldosterone corticotropin cytochrome p450 hemin adrenal cell aldosterone release animal cell cattle cell culture conference paper controlled study dose time effect relation enzyme activity incubation time liver metabolism metabolic regulation nonhuman steroidogenesis zona glomerulosa Aldosterone Animal Cattle Cells, Cultured Corticotropin Dicarbethoxydihydrocollidine Female Ferrochelatase Hemin Kinetics Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Zona Glomerulosa Animalia Bos taurus
spellingShingle	aldosterone stimulation, hemin hemin, aldosterone stimulation 1,4 dihydro 2,4,6 trimethyl 3,5 pyridinedicarboxylic acid diethyl ester aldosterone corticotropin cytochrome p450 hemin adrenal cell aldosterone release animal cell cattle cell culture conference paper controlled study dose time effect relation enzyme activity incubation time liver metabolism metabolic regulation nonhuman steroidogenesis zona glomerulosa Aldosterone Animal Cattle Cells, Cultured Corticotropin Dicarbethoxydihydrocollidine Female Ferrochelatase Hemin Kinetics Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Zona Glomerulosa Animalia Bos taurus Cozza, Eduardo Néstor Vila, María del Carmen Stimulation of aldosterone production by hemin in calf adrenal glomerulosa cell cultures
topic_facet	aldosterone stimulation, hemin hemin, aldosterone stimulation 1,4 dihydro 2,4,6 trimethyl 3,5 pyridinedicarboxylic acid diethyl ester aldosterone corticotropin cytochrome p450 hemin adrenal cell aldosterone release animal cell cattle cell culture conference paper controlled study dose time effect relation enzyme activity incubation time liver metabolism metabolic regulation nonhuman steroidogenesis zona glomerulosa Aldosterone Animal Cattle Cells, Cultured Corticotropin Dicarbethoxydihydrocollidine Female Ferrochelatase Hemin Kinetics Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S. Zona Glomerulosa Animalia Bos taurus
description	Aldosterone production from 11-deoxycorticosterone was stimulated by hemin in primary cultures and homogenates of calf adrenal zona glomerulosa, in a time- and dose-dependent fashion. The ferrochelatase inhibitor 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) blocked the stimulation of aldosterone mediated by adrenocorticotropin (ACTH). Addition of hemin after treatment with DDC partially restored ACTH action. These results suggest that hemin may play a role in regulation of aldosterone production. © 1993.
author	Cozza, Eduardo Néstor Vila, María del Carmen
author_facet	Cozza, Eduardo Néstor Vila, María del Carmen
author_sort	Cozza, Eduardo Néstor
title	Stimulation of aldosterone production by hemin in calf adrenal glomerulosa cell cultures
title_short	Stimulation of aldosterone production by hemin in calf adrenal glomerulosa cell cultures
title_full	Stimulation of aldosterone production by hemin in calf adrenal glomerulosa cell cultures
title_fullStr	Stimulation of aldosterone production by hemin in calf adrenal glomerulosa cell cultures
title_full_unstemmed	Stimulation of aldosterone production by hemin in calf adrenal glomerulosa cell cultures
title_sort	stimulation of aldosterone production by hemin in calf adrenal glomerulosa cell cultures
publishDate	1993
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0039128X_v58_n8_p384_Cozza http://hdl.handle.net/20.500.12110/paper_0039128X_v58_n8_p384_Cozza
work_keys_str_mv	AT cozzaeduardonestor stimulationofaldosteroneproductionbyheminincalfadrenalglomerulosacellcultures AT vilamariadelcarmen stimulationofaldosteroneproductionbyheminincalfadrenalglomerulosacellcultures
_version_	1768546388243644416

Stimulation of aldosterone production by hemin in calf adrenal glomerulosa cell cultures

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