Frustration in biomolecules

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Biomolecules are the prime information processing elements of living matter. Most of these inanimate systems are polymers that compute their own structures and dynamics using as input seemingly random character strings of their sequence, following which they coalesce and perform integrated cellular...

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Autor principal:	Ferreiro, Diego U.
Publicado:	2014
Materias:	biopolymer biochemistry chemistry human magnetism metabolism movement (physiology) procedures thermodynamics Biochemistry Biopolymers Humans Magnetic Phenomena Movement Thermodynamics
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00335835_v47_n4_p285_Ferreiro http://hdl.handle.net/20.500.12110/paper_00335835_v47_n4_p285_Ferreiro
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00335835_v47_n4_p285_Ferreiro
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spelling	paper:paper_00335835_v47_n4_p285_Ferreiro2023-06-08T15:00:34Z Frustration in biomolecules Ferreiro, Diego U. biopolymer biochemistry chemistry human magnetism metabolism movement (physiology) procedures thermodynamics Biochemistry Biopolymers Humans Magnetic Phenomena Movement Thermodynamics Biomolecules are the prime information processing elements of living matter. Most of these inanimate systems are polymers that compute their own structures and dynamics using as input seemingly random character strings of their sequence, following which they coalesce and perform integrated cellular functions. In large computational systems with finite interaction-codes, the appearance of conflicting goals is inevitable. Simple conflicting forces can lead to quite complex structures and behaviors, leading to the concept of frustration in condensed matter. We present here some basic ideas about frustration in biomolecules and how the frustration concept leads to a better appreciation of many aspects of the architecture of biomolecules, and especially how biomolecular structure connects to function by means of localized frustration. These ideas are simultaneously both seductively simple and perilously subtle to grasp completely. The energy landscape theory of protein folding provides a framework for quantifying frustration in large systems and has been implemented at many levels of description. We first review the notion of frustration from the areas of abstract logic and its uses in simple condensed matter systems. We discuss then how the frustration concept applies specifically to heteropolymers, testing folding landscape theory in computer simulations of protein models and in experimentally accessible systems. Studying the aspects of frustration averaged over many proteins provides ways to infer energy functions useful for reliable structure prediction. We discuss how frustration affects folding mechanisms. We review here how the biological functions of proteins are related to subtle local physical frustration effects and how frustration influences the appearance of metastable states, the nature of binding processes, catalysis and allosteric transitions. In this review, we also emphasize that frustration, far from being always a bad thing, is an essential feature of biomolecules that allows dynamics to be harnessed for function. In this way, we hope to illustrate how Frustration is a fundamental concept in molecular biology. © Cambridge University Press 2014. Fil:Ferreiro, D.U. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00335835_v47_n4_p285_Ferreiro http://hdl.handle.net/20.500.12110/paper_00335835_v47_n4_p285_Ferreiro
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	biopolymer biochemistry chemistry human magnetism metabolism movement (physiology) procedures thermodynamics Biochemistry Biopolymers Humans Magnetic Phenomena Movement Thermodynamics
spellingShingle	biopolymer biochemistry chemistry human magnetism metabolism movement (physiology) procedures thermodynamics Biochemistry Biopolymers Humans Magnetic Phenomena Movement Thermodynamics Ferreiro, Diego U. Frustration in biomolecules
topic_facet	biopolymer biochemistry chemistry human magnetism metabolism movement (physiology) procedures thermodynamics Biochemistry Biopolymers Humans Magnetic Phenomena Movement Thermodynamics
description	Biomolecules are the prime information processing elements of living matter. Most of these inanimate systems are polymers that compute their own structures and dynamics using as input seemingly random character strings of their sequence, following which they coalesce and perform integrated cellular functions. In large computational systems with finite interaction-codes, the appearance of conflicting goals is inevitable. Simple conflicting forces can lead to quite complex structures and behaviors, leading to the concept of frustration in condensed matter. We present here some basic ideas about frustration in biomolecules and how the frustration concept leads to a better appreciation of many aspects of the architecture of biomolecules, and especially how biomolecular structure connects to function by means of localized frustration. These ideas are simultaneously both seductively simple and perilously subtle to grasp completely. The energy landscape theory of protein folding provides a framework for quantifying frustration in large systems and has been implemented at many levels of description. We first review the notion of frustration from the areas of abstract logic and its uses in simple condensed matter systems. We discuss then how the frustration concept applies specifically to heteropolymers, testing folding landscape theory in computer simulations of protein models and in experimentally accessible systems. Studying the aspects of frustration averaged over many proteins provides ways to infer energy functions useful for reliable structure prediction. We discuss how frustration affects folding mechanisms. We review here how the biological functions of proteins are related to subtle local physical frustration effects and how frustration influences the appearance of metastable states, the nature of binding processes, catalysis and allosteric transitions. In this review, we also emphasize that frustration, far from being always a bad thing, is an essential feature of biomolecules that allows dynamics to be harnessed for function. In this way, we hope to illustrate how Frustration is a fundamental concept in molecular biology. © Cambridge University Press 2014.
author	Ferreiro, Diego U.
author_facet	Ferreiro, Diego U.
author_sort	Ferreiro, Diego U.
title	Frustration in biomolecules
title_short	Frustration in biomolecules
title_full	Frustration in biomolecules
title_fullStr	Frustration in biomolecules
title_full_unstemmed	Frustration in biomolecules
title_sort	frustration in biomolecules
publishDate	2014
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00335835_v47_n4_p285_Ferreiro http://hdl.handle.net/20.500.12110/paper_00335835_v47_n4_p285_Ferreiro
work_keys_str_mv	AT ferreirodiegou frustrationinbiomolecules
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Frustration in biomolecules

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