Evaluation of the antiviral activity against junin virus of macrocyclic trichothecenes produced by the hypocrealean epibiont of Baccharis coridifolia

Four macrocyclic trichothecenes, roridin A, roridin E, verrucarin A and verrucarin J, produced by the hypocrealean epibiont of Baccharis coridifolia, were evaluated for their inhibitory activity against the arenavirus Junin (JUNV), the etiological agent of Argentine hemorrhagic fever. The trichothec...

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Detalles Bibliográficos
Autores principales: García, Cybele Carina, Rosso, María Luciana, Bertoni, María Delia Luisa, Maier, Marta Silvia, Damonte, Elsa Beatriz
Publicado: 2002
Materias:
Antiviral activity
Arenaviruses
Asteraceae
Baccharis coridifolia
Junin virus
Trichothecenes
antivirus agent
macrocyclic compound
roridin A
roridin e
sesquiterpenoid
unclassified drug
verrucarin A
verrucarin j
animal cell
antiviral activity
Arenavirus
article
baccharis coridifolia
cell viability
concentration response
controlled study
dose response
drug screening
fungus
hemorrhagic fever
IC 50
nonhuman
virion
virus adsorption
virus inhibition
Animals
Antiviral Agents
Cercopithecus aethiops
Dose-Response Relationship, Drug
Plant Extracts
Vero Cells
Animalia
Argentina (fish)
Baccharis
Fungi
Hypocreales
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00320943_v68_n3_p209_Garcia
http://hdl.handle.net/20.500.12110/paper_00320943_v68_n3_p209_Garcia
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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