Antiproliferative terpenoids and alkaloids from the roots of Maytenus vitis-idaea and Maytenus spinosa
Investigation of the organic extracts of the roots of Maytenus vitis-idaea and Maytenus spinosa, collected in the province of Salta, Argentina, led to isolation of eighteen compounds belonging to several classes. From M. vitis-idaea, eight methylenequinone celastroids (1-8) were isolated, four of wh...
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Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00319422_v71_n14-15_p1741_DeAlmeida http://hdl.handle.net/20.500.12110/paper_00319422_v71_n14-15_p1741_DeAlmeida |
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paper:paper_00319422_v71_n14-15_p1741_DeAlmeida2023-06-08T14:59:41Z Antiproliferative terpenoids and alkaloids from the roots of Maytenus vitis-idaea and Maytenus spinosa Palermo, Jorge Alejandro β-Dihydroagarofuran sesquiterpenoid alkaloids Celastraceae Celastroids Maytenus spinosa Maytenus vitis-idaea Methylenequinone Pentacyclic triterpenoids alkaloid antineoplastic agent sesquiterpene triterpene Argentina article chemical structure chemistry dose response drug screening HeLa cell human isolation and purification Maytenus medicinal plant nuclear magnetic resonance plant root Alkaloids Antineoplastic Agents, Phytogenic Argentina Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Hela Cells Humans Maytenus Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plant Roots Plants, Medicinal Sesquiterpenes Triterpenes Celastraceae Idaea Maytenus Vitaceae Vitis Investigation of the organic extracts of the roots of Maytenus vitis-idaea and Maytenus spinosa, collected in the province of Salta, Argentina, led to isolation of eighteen compounds belonging to several classes. From M. vitis-idaea, eight methylenequinone celastroids (1-8) were isolated, four of which (4-7) were hitherto unknown. Additionally, from M. spinosa, two known celastroids, a known celastroid dimer (9), three pentacyclic triterpenoids (10-12) and six β-dihydroagarofuran sesquiterpenoid alkaloids (13-18) were identified. Compounds 4-7 were active against six solid tumor cell lines at micromolar concentrations. © 2010 Elsevier Ltd. All rights reserved. Fil:Palermo, J.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2010 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00319422_v71_n14-15_p1741_DeAlmeida http://hdl.handle.net/20.500.12110/paper_00319422_v71_n14-15_p1741_DeAlmeida |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
β-Dihydroagarofuran sesquiterpenoid alkaloids Celastraceae Celastroids Maytenus spinosa Maytenus vitis-idaea Methylenequinone Pentacyclic triterpenoids alkaloid antineoplastic agent sesquiterpene triterpene Argentina article chemical structure chemistry dose response drug screening HeLa cell human isolation and purification Maytenus medicinal plant nuclear magnetic resonance plant root Alkaloids Antineoplastic Agents, Phytogenic Argentina Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Hela Cells Humans Maytenus Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plant Roots Plants, Medicinal Sesquiterpenes Triterpenes Celastraceae Idaea Maytenus Vitaceae Vitis |
spellingShingle |
β-Dihydroagarofuran sesquiterpenoid alkaloids Celastraceae Celastroids Maytenus spinosa Maytenus vitis-idaea Methylenequinone Pentacyclic triterpenoids alkaloid antineoplastic agent sesquiterpene triterpene Argentina article chemical structure chemistry dose response drug screening HeLa cell human isolation and purification Maytenus medicinal plant nuclear magnetic resonance plant root Alkaloids Antineoplastic Agents, Phytogenic Argentina Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Hela Cells Humans Maytenus Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plant Roots Plants, Medicinal Sesquiterpenes Triterpenes Celastraceae Idaea Maytenus Vitaceae Vitis Palermo, Jorge Alejandro Antiproliferative terpenoids and alkaloids from the roots of Maytenus vitis-idaea and Maytenus spinosa |
topic_facet |
β-Dihydroagarofuran sesquiterpenoid alkaloids Celastraceae Celastroids Maytenus spinosa Maytenus vitis-idaea Methylenequinone Pentacyclic triterpenoids alkaloid antineoplastic agent sesquiterpene triterpene Argentina article chemical structure chemistry dose response drug screening HeLa cell human isolation and purification Maytenus medicinal plant nuclear magnetic resonance plant root Alkaloids Antineoplastic Agents, Phytogenic Argentina Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Hela Cells Humans Maytenus Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plant Roots Plants, Medicinal Sesquiterpenes Triterpenes Celastraceae Idaea Maytenus Vitaceae Vitis |
description |
Investigation of the organic extracts of the roots of Maytenus vitis-idaea and Maytenus spinosa, collected in the province of Salta, Argentina, led to isolation of eighteen compounds belonging to several classes. From M. vitis-idaea, eight methylenequinone celastroids (1-8) were isolated, four of which (4-7) were hitherto unknown. Additionally, from M. spinosa, two known celastroids, a known celastroid dimer (9), three pentacyclic triterpenoids (10-12) and six β-dihydroagarofuran sesquiterpenoid alkaloids (13-18) were identified. Compounds 4-7 were active against six solid tumor cell lines at micromolar concentrations. © 2010 Elsevier Ltd. All rights reserved. |
author |
Palermo, Jorge Alejandro |
author_facet |
Palermo, Jorge Alejandro |
author_sort |
Palermo, Jorge Alejandro |
title |
Antiproliferative terpenoids and alkaloids from the roots of Maytenus vitis-idaea and Maytenus spinosa |
title_short |
Antiproliferative terpenoids and alkaloids from the roots of Maytenus vitis-idaea and Maytenus spinosa |
title_full |
Antiproliferative terpenoids and alkaloids from the roots of Maytenus vitis-idaea and Maytenus spinosa |
title_fullStr |
Antiproliferative terpenoids and alkaloids from the roots of Maytenus vitis-idaea and Maytenus spinosa |
title_full_unstemmed |
Antiproliferative terpenoids and alkaloids from the roots of Maytenus vitis-idaea and Maytenus spinosa |
title_sort |
antiproliferative terpenoids and alkaloids from the roots of maytenus vitis-idaea and maytenus spinosa |
publishDate |
2010 |
url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00319422_v71_n14-15_p1741_DeAlmeida http://hdl.handle.net/20.500.12110/paper_00319422_v71_n14-15_p1741_DeAlmeida |
work_keys_str_mv |
AT palermojorgealejandro antiproliferativeterpenoidsandalkaloidsfromtherootsofmaytenusvitisidaeaandmaytenusspinosa |
_version_ |
1768542353533960192 |