Cytotoxic terpenoids from Nardophyllum bryoides

The investigation of the ethanol extract of fresh aerial parts of the Patagonian shrub Nardophyllum bryoides collected in the province of Chubut, Argentina, yielded eleven terpenoids. These include: three seco-ent-halimane diterpenoids (1-3), two ent-halimanes (4-5) and six pentacyclic oleanane and...

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Publicado:	2010
Materias:	Astereae Nardophyllum bryoides Seco-chiliolidic acid Seco-ent-halimane Terpenoid antineoplastic agent diterpene drug derivative oleanolic acid terpene Argentina article Asteraceae chemical structure chemistry drug screening human isolation and purification nuclear magnetic resonance analogs and derivatives Antineoplastic Agents, Phytogenic Diterpenes Drug Screening Assays, Antitumor Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oleanolic Acid Terpenes
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00319422_v71_n11-12_p1395_Sanchez http://hdl.handle.net/20.500.12110/paper_00319422_v71_n11-12_p1395_Sanchez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00319422_v71_n11-12_p1395_Sanchez
record_format	dspace
spelling	paper:paper_00319422_v71_n11-12_p1395_Sanchez2023-06-08T14:59:41Z Cytotoxic terpenoids from Nardophyllum bryoides Astereae Nardophyllum bryoides Seco-chiliolidic acid Seco-ent-halimane Terpenoid antineoplastic agent diterpene drug derivative oleanolic acid terpene antineoplastic agent terpene Argentina article Asteraceae chemical structure chemistry drug screening human isolation and purification nuclear magnetic resonance analogs and derivatives Asteraceae isolation and purification Antineoplastic Agents, Phytogenic Argentina Asteraceae Diterpenes Drug Screening Assays, Antitumor Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oleanolic Acid Terpenes Astereae Nardophyllum bryoides Antineoplastic Agents, Phytogenic Argentina Asteraceae Diterpenes Drug Screening Assays, Antitumor Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oleanolic Acid Terpenes The investigation of the ethanol extract of fresh aerial parts of the Patagonian shrub Nardophyllum bryoides collected in the province of Chubut, Argentina, yielded eleven terpenoids. These include: three seco-ent-halimane diterpenoids (1-3), two ent-halimanes (4-5) and six pentacyclic oleanane and ursane triterpenoids (6-11). Four of these compounds (2, 6, 8 and 11) are hitherto unknown, while two others (1 and 4) have been previously reported but only as synthetic products. Several of these compounds showed moderate cytotoxicity against a human pancreatic adenocarcinoma cell line while compounds 4 and 5 were active at micromolar concentrations. The main component, seco-chiliolidic acid (1), could be isolated from this extract in large amounts, turning N. bryoides into a sustainable source of this bioactive compound. © 2010 Elsevier Ltd. All rights reserved. 2010 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00319422_v71_n11-12_p1395_Sanchez http://hdl.handle.net/20.500.12110/paper_00319422_v71_n11-12_p1395_Sanchez
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Astereae Nardophyllum bryoides Seco-chiliolidic acid Seco-ent-halimane Terpenoid antineoplastic agent diterpene drug derivative oleanolic acid terpene antineoplastic agent terpene Argentina article Asteraceae chemical structure chemistry drug screening human isolation and purification nuclear magnetic resonance analogs and derivatives Asteraceae isolation and purification Antineoplastic Agents, Phytogenic Argentina Asteraceae Diterpenes Drug Screening Assays, Antitumor Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oleanolic Acid Terpenes Astereae Nardophyllum bryoides Antineoplastic Agents, Phytogenic Argentina Asteraceae Diterpenes Drug Screening Assays, Antitumor Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oleanolic Acid Terpenes
spellingShingle	Astereae Nardophyllum bryoides Seco-chiliolidic acid Seco-ent-halimane Terpenoid antineoplastic agent diterpene drug derivative oleanolic acid terpene antineoplastic agent terpene Argentina article Asteraceae chemical structure chemistry drug screening human isolation and purification nuclear magnetic resonance analogs and derivatives Asteraceae isolation and purification Antineoplastic Agents, Phytogenic Argentina Asteraceae Diterpenes Drug Screening Assays, Antitumor Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oleanolic Acid Terpenes Astereae Nardophyllum bryoides Antineoplastic Agents, Phytogenic Argentina Asteraceae Diterpenes Drug Screening Assays, Antitumor Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oleanolic Acid Terpenes Cytotoxic terpenoids from Nardophyllum bryoides
topic_facet	Astereae Nardophyllum bryoides Seco-chiliolidic acid Seco-ent-halimane Terpenoid antineoplastic agent diterpene drug derivative oleanolic acid terpene antineoplastic agent terpene Argentina article Asteraceae chemical structure chemistry drug screening human isolation and purification nuclear magnetic resonance analogs and derivatives Asteraceae isolation and purification Antineoplastic Agents, Phytogenic Argentina Asteraceae Diterpenes Drug Screening Assays, Antitumor Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oleanolic Acid Terpenes Astereae Nardophyllum bryoides Antineoplastic Agents, Phytogenic Argentina Asteraceae Diterpenes Drug Screening Assays, Antitumor Humans Molecular Structure Nuclear Magnetic Resonance, Biomolecular Oleanolic Acid Terpenes
description	The investigation of the ethanol extract of fresh aerial parts of the Patagonian shrub Nardophyllum bryoides collected in the province of Chubut, Argentina, yielded eleven terpenoids. These include: three seco-ent-halimane diterpenoids (1-3), two ent-halimanes (4-5) and six pentacyclic oleanane and ursane triterpenoids (6-11). Four of these compounds (2, 6, 8 and 11) are hitherto unknown, while two others (1 and 4) have been previously reported but only as synthetic products. Several of these compounds showed moderate cytotoxicity against a human pancreatic adenocarcinoma cell line while compounds 4 and 5 were active at micromolar concentrations. The main component, seco-chiliolidic acid (1), could be isolated from this extract in large amounts, turning N. bryoides into a sustainable source of this bioactive compound. © 2010 Elsevier Ltd. All rights reserved.
title	Cytotoxic terpenoids from Nardophyllum bryoides
title_short	Cytotoxic terpenoids from Nardophyllum bryoides
title_full	Cytotoxic terpenoids from Nardophyllum bryoides
title_fullStr	Cytotoxic terpenoids from Nardophyllum bryoides
title_full_unstemmed	Cytotoxic terpenoids from Nardophyllum bryoides
title_sort	cytotoxic terpenoids from nardophyllum bryoides
publishDate	2010
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00319422_v71_n11-12_p1395_Sanchez http://hdl.handle.net/20.500.12110/paper_00319422_v71_n11-12_p1395_Sanchez
_version_	1768545964602163200

Cytotoxic terpenoids from Nardophyllum bryoides

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