Photophysics of zinc (II) phthalocyanine polymer and gel formulation
The photophysical properties of lipophilic phthalocyanines encapsulated into a polymer and two different gels were studied in order to predict their photosensitizing efficacy in vivo. Photophysical techniques for solid phase were adapted for light dispersing samples. Gel formulation of two tetrasubs...
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2010
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00318655_v86_n3_p513_Rodriguez http://hdl.handle.net/20.500.12110/paper_00318655_v86_n3_p513_Rodriguez |
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paper:paper_00318655_v86_n3_p513_Rodriguez2023-06-08T14:57:24Z Photophysics of zinc (II) phthalocyanine polymer and gel formulation indole derivative photosensitizing agent phthalocyanine polymer singlet oxygen zinc gel indole derivative microcapsule polymer article chemistry gel methodology microcapsule permeability photochemistry photochemotherapy radiation exposure chemistry gel procedures radiation response Capsules Gels Indoles Permeability Photochemical Processes Photochemotherapy Photosensitizing Agents Polymers Singlet Oxygen Zinc Tetra Capsules Gels Indoles Permeability Photochemical Processes Photochemotherapy Photosensitizing Agents Polymers Singlet Oxygen Zinc The photophysical properties of lipophilic phthalocyanines encapsulated into a polymer and two different gels were studied in order to predict their photosensitizing efficacy in vivo. Photophysical techniques for solid phase were adapted for light dispersing samples. Gel formulation of two tetrasubstituted phthalocyanines, tetra-t-butylphthalocyaninato zinc(II) (1), tetrakis(1,1-dimethyl-2-phthalimido)ethylphtalocyaninatozinc(II) (2) and two octasubstituted phthalocyanines, 2,3,9,10,16,17,23,24-octakis(decyloxy) phthalocyaninatozinc(II) (3) and 2,3,9,10,16,17,23,24-octakis[(N,N- dimethylamino)ethylsulfanyl]phthalocyaninatozinc(II) (4) were investigated for their possible use in photodynamic therapy for topical purposes. Supporting the fact that gel formulation improves the photophysical properties of phthalocyanines, singlet molecular oxygen quantum yield (Pδ) values for 1-4 zinc(II) phthalocyaninates in Lutrol® F 127-Cremophor® RH 40 were 0.60, 0.60, 0.20 and 0.26, respectively. Permeation studies showed that no release of phthalocyanines occurs, thus indicating there should be no risk of generalized skin photosensitivity in areas other than the dye-deposition site. 2010 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00318655_v86_n3_p513_Rodriguez http://hdl.handle.net/20.500.12110/paper_00318655_v86_n3_p513_Rodriguez |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
indole derivative photosensitizing agent phthalocyanine polymer singlet oxygen zinc gel indole derivative microcapsule polymer article chemistry gel methodology microcapsule permeability photochemistry photochemotherapy radiation exposure chemistry gel procedures radiation response Capsules Gels Indoles Permeability Photochemical Processes Photochemotherapy Photosensitizing Agents Polymers Singlet Oxygen Zinc Tetra Capsules Gels Indoles Permeability Photochemical Processes Photochemotherapy Photosensitizing Agents Polymers Singlet Oxygen Zinc |
| spellingShingle |
indole derivative photosensitizing agent phthalocyanine polymer singlet oxygen zinc gel indole derivative microcapsule polymer article chemistry gel methodology microcapsule permeability photochemistry photochemotherapy radiation exposure chemistry gel procedures radiation response Capsules Gels Indoles Permeability Photochemical Processes Photochemotherapy Photosensitizing Agents Polymers Singlet Oxygen Zinc Tetra Capsules Gels Indoles Permeability Photochemical Processes Photochemotherapy Photosensitizing Agents Polymers Singlet Oxygen Zinc Photophysics of zinc (II) phthalocyanine polymer and gel formulation |
| topic_facet |
indole derivative photosensitizing agent phthalocyanine polymer singlet oxygen zinc gel indole derivative microcapsule polymer article chemistry gel methodology microcapsule permeability photochemistry photochemotherapy radiation exposure chemistry gel procedures radiation response Capsules Gels Indoles Permeability Photochemical Processes Photochemotherapy Photosensitizing Agents Polymers Singlet Oxygen Zinc Tetra Capsules Gels Indoles Permeability Photochemical Processes Photochemotherapy Photosensitizing Agents Polymers Singlet Oxygen Zinc |
| description |
The photophysical properties of lipophilic phthalocyanines encapsulated into a polymer and two different gels were studied in order to predict their photosensitizing efficacy in vivo. Photophysical techniques for solid phase were adapted for light dispersing samples. Gel formulation of two tetrasubstituted phthalocyanines, tetra-t-butylphthalocyaninato zinc(II) (1), tetrakis(1,1-dimethyl-2-phthalimido)ethylphtalocyaninatozinc(II) (2) and two octasubstituted phthalocyanines, 2,3,9,10,16,17,23,24-octakis(decyloxy) phthalocyaninatozinc(II) (3) and 2,3,9,10,16,17,23,24-octakis[(N,N- dimethylamino)ethylsulfanyl]phthalocyaninatozinc(II) (4) were investigated for their possible use in photodynamic therapy for topical purposes. Supporting the fact that gel formulation improves the photophysical properties of phthalocyanines, singlet molecular oxygen quantum yield (Pδ) values for 1-4 zinc(II) phthalocyaninates in Lutrol® F 127-Cremophor® RH 40 were 0.60, 0.60, 0.20 and 0.26, respectively. Permeation studies showed that no release of phthalocyanines occurs, thus indicating there should be no risk of generalized skin photosensitivity in areas other than the dye-deposition site. |
| title |
Photophysics of zinc (II) phthalocyanine polymer and gel formulation |
| title_short |
Photophysics of zinc (II) phthalocyanine polymer and gel formulation |
| title_full |
Photophysics of zinc (II) phthalocyanine polymer and gel formulation |
| title_fullStr |
Photophysics of zinc (II) phthalocyanine polymer and gel formulation |
| title_full_unstemmed |
Photophysics of zinc (II) phthalocyanine polymer and gel formulation |
| title_sort |
photophysics of zinc (ii) phthalocyanine polymer and gel formulation |
| publishDate |
2010 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00318655_v86_n3_p513_Rodriguez http://hdl.handle.net/20.500.12110/paper_00318655_v86_n3_p513_Rodriguez |
| _version_ |
1768543790265532416 |