Is there a role for dopamine in the regulation of motility of sow oviducts?
Dose-response curves for norepinephrine (NE), dopamine (DA) and 2-bromo-α-ergocryptine (BEC) in the isthmic and ampullary regions isolated from proastrous sow oviducts, were drawn. NE, DA and BEC depressed the contractile activity of ampullary segments in dose-dependent fashion. In the isthmic regio...
| Publicado: |
1983
|
|---|---|
| Materias: | |
| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00316989_v15_n10_p923_Chaud http://hdl.handle.net/20.500.12110/paper_00316989_v15_n10_p923_Chaud |
| Aporte de: |
| id |
paper:paper_00316989_v15_n10_p923_Chaud |
|---|---|
| record_format |
dspace |
| spelling |
paper:paper_00316989_v15_n10_p923_Chaud2023-06-08T14:57:09Z Is there a role for dopamine in the regulation of motility of sow oviducts? bromocriptine chlorpromazine dopamine haloperidol noradrenalin propranolol spiperone animal cell drug efficacy drug mechanism estrus female genital system muscle nonhuman smooth muscle contractility swine uterine tube Animals Dopamine Fallopian Tubes Female Swine Dose-response curves for norepinephrine (NE), dopamine (DA) and 2-bromo-α-ergocryptine (BEC) in the isthmic and ampullary regions isolated from proastrous sow oviducts, were drawn. NE, DA and BEC depressed the contractile activity of ampullary segments in dose-dependent fashion. In the isthmic region, NE induced a dose-related stimulation whereas DA and BEC evoked relaxation. Propranolol (10-6M) did not modify significantly the effect of DA on the ampulla, shereas spiperone, chlorpromazine and haloperidol, shifted to the right DA dose-response curves. Haloperidol and spiperone were able to partially antagonize responses to DA of the isthmus. The catecholamine contents of the ampullary (a) and isthmic (i) regions of sow oviducts during proestrus (P), estrus (E) and metestrus (M) proved to be quite different and differently affected by the variations of the sex cycle: NE, DA and spinephrine (EPI) in (i) higher than in (a); NE in (i) and (a) during M higher than during E; NE in (i) lower during E than during P. The probable presence of specific dopamine receptors in sow oviducts as well as their eventual role in modulating tubal motility are discussed in this paper. © 1983 The Italian Pharmacological Society. 1983 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00316989_v15_n10_p923_Chaud http://hdl.handle.net/20.500.12110/paper_00316989_v15_n10_p923_Chaud |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
bromocriptine chlorpromazine dopamine haloperidol noradrenalin propranolol spiperone animal cell drug efficacy drug mechanism estrus female genital system muscle nonhuman smooth muscle contractility swine uterine tube Animals Dopamine Fallopian Tubes Female Swine |
| spellingShingle |
bromocriptine chlorpromazine dopamine haloperidol noradrenalin propranolol spiperone animal cell drug efficacy drug mechanism estrus female genital system muscle nonhuman smooth muscle contractility swine uterine tube Animals Dopamine Fallopian Tubes Female Swine Is there a role for dopamine in the regulation of motility of sow oviducts? |
| topic_facet |
bromocriptine chlorpromazine dopamine haloperidol noradrenalin propranolol spiperone animal cell drug efficacy drug mechanism estrus female genital system muscle nonhuman smooth muscle contractility swine uterine tube Animals Dopamine Fallopian Tubes Female Swine |
| description |
Dose-response curves for norepinephrine (NE), dopamine (DA) and 2-bromo-α-ergocryptine (BEC) in the isthmic and ampullary regions isolated from proastrous sow oviducts, were drawn. NE, DA and BEC depressed the contractile activity of ampullary segments in dose-dependent fashion. In the isthmic region, NE induced a dose-related stimulation whereas DA and BEC evoked relaxation. Propranolol (10-6M) did not modify significantly the effect of DA on the ampulla, shereas spiperone, chlorpromazine and haloperidol, shifted to the right DA dose-response curves. Haloperidol and spiperone were able to partially antagonize responses to DA of the isthmus. The catecholamine contents of the ampullary (a) and isthmic (i) regions of sow oviducts during proestrus (P), estrus (E) and metestrus (M) proved to be quite different and differently affected by the variations of the sex cycle: NE, DA and spinephrine (EPI) in (i) higher than in (a); NE in (i) and (a) during M higher than during E; NE in (i) lower during E than during P. The probable presence of specific dopamine receptors in sow oviducts as well as their eventual role in modulating tubal motility are discussed in this paper. © 1983 The Italian Pharmacological Society. |
| title |
Is there a role for dopamine in the regulation of motility of sow oviducts? |
| title_short |
Is there a role for dopamine in the regulation of motility of sow oviducts? |
| title_full |
Is there a role for dopamine in the regulation of motility of sow oviducts? |
| title_fullStr |
Is there a role for dopamine in the regulation of motility of sow oviducts? |
| title_full_unstemmed |
Is there a role for dopamine in the regulation of motility of sow oviducts? |
| title_sort |
is there a role for dopamine in the regulation of motility of sow oviducts? |
| publishDate |
1983 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00316989_v15_n10_p923_Chaud http://hdl.handle.net/20.500.12110/paper_00316989_v15_n10_p923_Chaud |
| _version_ |
1768541646407860224 |