Alpha and beta sympathetic responses to isoproterenol by the isolated rat vas deferens
Potency and efficacy of isoproterenol were different in the epididymal and in the prostatic portion of the rat vas deferens as well as between preparations obtained from normal or castrated animals. The epididymal portion exhibited alpha excitatory as well as beta inhibitory effects following isopro...
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1981
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00316989_v13_n5_p487_Borde http://hdl.handle.net/20.500.12110/paper_00316989_v13_n5_p487_Borde |
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paper:paper_00316989_v13_n5_p487_Borde |
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paper:paper_00316989_v13_n5_p487_Borde2025-07-30T17:38:25Z Alpha and beta sympathetic responses to isoproterenol by the isolated rat vas deferens adrenergic receptor alpha adrenergic receptor barium chloride beta adrenergic receptor isoprenaline phentolamine phentolamine mesylate propranolol animal experiment autonomic nervous system castration in vitro study male genital system rat smooth muscle contractility vas deferens Animal Castration Dose-Response Relationship, Drug Epididymis In Vitro Isoproterenol Male Muscle Contraction Prostate Rats Rats, Inbred Strains Receptors, Adrenergic Receptors, Adrenergic, alpha Receptors, Adrenergic, beta Support, Non-U.S. Gov't Vas Deferens Potency and efficacy of isoproterenol were different in the epididymal and in the prostatic portion of the rat vas deferens as well as between preparations obtained from normal or castrated animals. The epididymal portion exhibited alpha excitatory as well as beta inhibitory effects following isoproterenol; whereas the prostatic part reacted with an excitatory response to isoproterenol only in the castrated group. Phentolamine blocked the excitatory action and propranolol the inhibitory one. The variable differences to the alpha excitatory and beta inhibitory effects of isoproterenol between preparations from normal and castrated rats, could be due to a apecial postjunctional supersensitivity related to the lack of testosterone. © 1981 The Italian Pharmacological Society. 1981 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00316989_v13_n5_p487_Borde http://hdl.handle.net/20.500.12110/paper_00316989_v13_n5_p487_Borde |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
adrenergic receptor alpha adrenergic receptor barium chloride beta adrenergic receptor isoprenaline phentolamine phentolamine mesylate propranolol animal experiment autonomic nervous system castration in vitro study male genital system rat smooth muscle contractility vas deferens Animal Castration Dose-Response Relationship, Drug Epididymis In Vitro Isoproterenol Male Muscle Contraction Prostate Rats Rats, Inbred Strains Receptors, Adrenergic Receptors, Adrenergic, alpha Receptors, Adrenergic, beta Support, Non-U.S. Gov't Vas Deferens |
| spellingShingle |
adrenergic receptor alpha adrenergic receptor barium chloride beta adrenergic receptor isoprenaline phentolamine phentolamine mesylate propranolol animal experiment autonomic nervous system castration in vitro study male genital system rat smooth muscle contractility vas deferens Animal Castration Dose-Response Relationship, Drug Epididymis In Vitro Isoproterenol Male Muscle Contraction Prostate Rats Rats, Inbred Strains Receptors, Adrenergic Receptors, Adrenergic, alpha Receptors, Adrenergic, beta Support, Non-U.S. Gov't Vas Deferens Alpha and beta sympathetic responses to isoproterenol by the isolated rat vas deferens |
| topic_facet |
adrenergic receptor alpha adrenergic receptor barium chloride beta adrenergic receptor isoprenaline phentolamine phentolamine mesylate propranolol animal experiment autonomic nervous system castration in vitro study male genital system rat smooth muscle contractility vas deferens Animal Castration Dose-Response Relationship, Drug Epididymis In Vitro Isoproterenol Male Muscle Contraction Prostate Rats Rats, Inbred Strains Receptors, Adrenergic Receptors, Adrenergic, alpha Receptors, Adrenergic, beta Support, Non-U.S. Gov't Vas Deferens |
| description |
Potency and efficacy of isoproterenol were different in the epididymal and in the prostatic portion of the rat vas deferens as well as between preparations obtained from normal or castrated animals. The epididymal portion exhibited alpha excitatory as well as beta inhibitory effects following isoproterenol; whereas the prostatic part reacted with an excitatory response to isoproterenol only in the castrated group. Phentolamine blocked the excitatory action and propranolol the inhibitory one. The variable differences to the alpha excitatory and beta inhibitory effects of isoproterenol between preparations from normal and castrated rats, could be due to a apecial postjunctional supersensitivity related to the lack of testosterone. © 1981 The Italian Pharmacological Society. |
| title |
Alpha and beta sympathetic responses to isoproterenol by the isolated rat vas deferens |
| title_short |
Alpha and beta sympathetic responses to isoproterenol by the isolated rat vas deferens |
| title_full |
Alpha and beta sympathetic responses to isoproterenol by the isolated rat vas deferens |
| title_fullStr |
Alpha and beta sympathetic responses to isoproterenol by the isolated rat vas deferens |
| title_full_unstemmed |
Alpha and beta sympathetic responses to isoproterenol by the isolated rat vas deferens |
| title_sort |
alpha and beta sympathetic responses to isoproterenol by the isolated rat vas deferens |
| publishDate |
1981 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00316989_v13_n5_p487_Borde http://hdl.handle.net/20.500.12110/paper_00316989_v13_n5_p487_Borde |
| _version_ |
1840323514556481536 |