Role of ACTH on the effect of medroxyprogesterone in brain stem serotonin
Pregnenolone, medroxyprogesterone (MPA) and melengestrol (MLA) caused a significant decrease of brain stem serotonin (5-HT) in the adult female rat, without modifying the content of 5-hydroxy indoleacetic acid (5-HIAA). Only MPA and MLA increased the liver tryptophan pyrrolase (LTP) activity. Chlorm...
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1978
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00316989_v10_n7_p643_Izquierdo http://hdl.handle.net/20.500.12110/paper_00316989_v10_n7_p643_Izquierdo |
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paper:paper_00316989_v10_n7_p643_Izquierdo2023-06-08T14:57:05Z Role of ACTH on the effect of medroxyprogesterone in brain stem serotonin 16alpha methylpregnenolone chlormadinone corticotropin deoxycorticosterone enzyme hydroxyprogesterone medroxyprogesterone medroxyprogesterone acetate melengestrol acetate pregnenolone progesterone acetate serotonin tetracosactide tryptophan 2,3 dioxygenase unclassified drug animal experiment article brain stem central nervous system drug antagonism drug comparison endocrine system rat subcutaneous drug administration Animals, Laboratory Biology Clinical Research Contraception Contraceptive Agents, Female--pharmacodynamics Contraceptive Agents, Progestin--pharmacodynamics Contraceptive Agents--pharmacodynamics Family Planning Hormones Laboratory Procedures Literature Review Medroxyprogesterone Acetate--pharmacodynamics Melengestrol Acetate--pharmacodynamics Physiology Research Methodology Serotonin Adrenalectomy Adrenocorticotropic Hormone Animals Brain Stem Fasting Female Hydroxyindoleacetic Acid Medroxyprogesterone Monoamine Oxidase Rats Serotonin Tryptophan Pregnenolone, medroxyprogesterone (MPA) and melengestrol (MLA) caused a significant decrease of brain stem serotonin (5-HT) in the adult female rat, without modifying the content of 5-hydroxy indoleacetic acid (5-HIAA). Only MPA and MLA increased the liver tryptophan pyrrolase (LTP) activity. Chlormadinone, in spite of its similar chemical structure, had no effect. Both total and free plasma tryptophan were not modified, except the latter which decreased when MPA was injected. The steroids herein studied had no effect on brain stem tryptophan and monoamino oxidase (MAO) system activity. The effect of MPA on 5-HT was antagonized in fasting, adrenalectomized and normal rats injected with ACTH. These results suggest that ACTH would participate in the effect of MPA on brain stem 5-HT. © 1978 The Italian Pharmacological Society. 1978 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00316989_v10_n7_p643_Izquierdo http://hdl.handle.net/20.500.12110/paper_00316989_v10_n7_p643_Izquierdo |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
16alpha methylpregnenolone chlormadinone corticotropin deoxycorticosterone enzyme hydroxyprogesterone medroxyprogesterone medroxyprogesterone acetate melengestrol acetate pregnenolone progesterone acetate serotonin tetracosactide tryptophan 2,3 dioxygenase unclassified drug animal experiment article brain stem central nervous system drug antagonism drug comparison endocrine system rat subcutaneous drug administration Animals, Laboratory Biology Clinical Research Contraception Contraceptive Agents, Female--pharmacodynamics Contraceptive Agents, Progestin--pharmacodynamics Contraceptive Agents--pharmacodynamics Family Planning Hormones Laboratory Procedures Literature Review Medroxyprogesterone Acetate--pharmacodynamics Melengestrol Acetate--pharmacodynamics Physiology Research Methodology Serotonin Adrenalectomy Adrenocorticotropic Hormone Animals Brain Stem Fasting Female Hydroxyindoleacetic Acid Medroxyprogesterone Monoamine Oxidase Rats Serotonin Tryptophan |
| spellingShingle |
16alpha methylpregnenolone chlormadinone corticotropin deoxycorticosterone enzyme hydroxyprogesterone medroxyprogesterone medroxyprogesterone acetate melengestrol acetate pregnenolone progesterone acetate serotonin tetracosactide tryptophan 2,3 dioxygenase unclassified drug animal experiment article brain stem central nervous system drug antagonism drug comparison endocrine system rat subcutaneous drug administration Animals, Laboratory Biology Clinical Research Contraception Contraceptive Agents, Female--pharmacodynamics Contraceptive Agents, Progestin--pharmacodynamics Contraceptive Agents--pharmacodynamics Family Planning Hormones Laboratory Procedures Literature Review Medroxyprogesterone Acetate--pharmacodynamics Melengestrol Acetate--pharmacodynamics Physiology Research Methodology Serotonin Adrenalectomy Adrenocorticotropic Hormone Animals Brain Stem Fasting Female Hydroxyindoleacetic Acid Medroxyprogesterone Monoamine Oxidase Rats Serotonin Tryptophan Role of ACTH on the effect of medroxyprogesterone in brain stem serotonin |
| topic_facet |
16alpha methylpregnenolone chlormadinone corticotropin deoxycorticosterone enzyme hydroxyprogesterone medroxyprogesterone medroxyprogesterone acetate melengestrol acetate pregnenolone progesterone acetate serotonin tetracosactide tryptophan 2,3 dioxygenase unclassified drug animal experiment article brain stem central nervous system drug antagonism drug comparison endocrine system rat subcutaneous drug administration Animals, Laboratory Biology Clinical Research Contraception Contraceptive Agents, Female--pharmacodynamics Contraceptive Agents, Progestin--pharmacodynamics Contraceptive Agents--pharmacodynamics Family Planning Hormones Laboratory Procedures Literature Review Medroxyprogesterone Acetate--pharmacodynamics Melengestrol Acetate--pharmacodynamics Physiology Research Methodology Serotonin Adrenalectomy Adrenocorticotropic Hormone Animals Brain Stem Fasting Female Hydroxyindoleacetic Acid Medroxyprogesterone Monoamine Oxidase Rats Serotonin Tryptophan |
| description |
Pregnenolone, medroxyprogesterone (MPA) and melengestrol (MLA) caused a significant decrease of brain stem serotonin (5-HT) in the adult female rat, without modifying the content of 5-hydroxy indoleacetic acid (5-HIAA). Only MPA and MLA increased the liver tryptophan pyrrolase (LTP) activity. Chlormadinone, in spite of its similar chemical structure, had no effect. Both total and free plasma tryptophan were not modified, except the latter which decreased when MPA was injected. The steroids herein studied had no effect on brain stem tryptophan and monoamino oxidase (MAO) system activity. The effect of MPA on 5-HT was antagonized in fasting, adrenalectomized and normal rats injected with ACTH. These results suggest that ACTH would participate in the effect of MPA on brain stem 5-HT. © 1978 The Italian Pharmacological Society. |
| title |
Role of ACTH on the effect of medroxyprogesterone in brain stem serotonin |
| title_short |
Role of ACTH on the effect of medroxyprogesterone in brain stem serotonin |
| title_full |
Role of ACTH on the effect of medroxyprogesterone in brain stem serotonin |
| title_fullStr |
Role of ACTH on the effect of medroxyprogesterone in brain stem serotonin |
| title_full_unstemmed |
Role of ACTH on the effect of medroxyprogesterone in brain stem serotonin |
| title_sort |
role of acth on the effect of medroxyprogesterone in brain stem serotonin |
| publishDate |
1978 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00316989_v10_n7_p643_Izquierdo http://hdl.handle.net/20.500.12110/paper_00316989_v10_n7_p643_Izquierdo |
| _version_ |
1768541740303646720 |