How does the stimulus define exocytosis in adrenal chromaffin cells?
The extent and type of hormones and active peptides secreted by the chromaffin cells of the adrenal medulla have to be adjusted to physiological requirements. The chromaffin cell secretory activity is controlled by the splanchnic nerve firing frequency, which goes from approximately 0.5 Hz in basal...
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2018
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00316768_v470_n1_p155_Marengo http://hdl.handle.net/20.500.12110/paper_00316768_v470_n1_p155_Marengo |
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paper:paper_00316768_v470_n1_p155_Marengo2023-06-08T14:57:04Z How does the stimulus define exocytosis in adrenal chromaffin cells? Catecholamines Chromaffin cells Exocytosis Vesicle pools Voltage-dependent Ca2+ channels calcium channel Munc13 protein Munc18 protein myosin adenosine triphosphatase protein SNARE protein synaptotagmin I unclassified drug calcium channel vesicular transport protein adrenal chromaffin cell calcium signaling cell fusion cell membrane chromaffin granule exocytosis nonhuman priority journal Review secretory granule stimulus adrenal medulla animal human metabolism secretion (process) Adrenal Medulla Animals Calcium Channels Chromaffin Granules Exocytosis Humans Vesicular Transport Proteins The extent and type of hormones and active peptides secreted by the chromaffin cells of the adrenal medulla have to be adjusted to physiological requirements. The chromaffin cell secretory activity is controlled by the splanchnic nerve firing frequency, which goes from approximately 0.5 Hz in basal conditions to more than 15 Hz in stress. Thus, these neuroendocrine cells maintain a tonic release of catecholamines under resting conditions, massively discharge intravesicular transmitters in response to stress, or adequately respond to moderate stimuli. In order to adjust the secretory response to the stimulus, the adrenal chromaffin cells have an appropriate organization of Ca2+ channels, secretory granules pools, and sets of proteins dedicated to selectively control different steps of the secretion process, such as the traffic, docking, priming and fusion of the chromaffin granules. Among the molecules implicated in such events are the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins, Ca2+ sensors like Munc13 and synaptotagmin-1, chaperon proteins such as Munc18, and the actomyosin complex. In the present review, we discuss how these different actors contribute to the extent and maintenance of the stimulus-dependent exocytosis in the adrenal chromaffin cells. © 2017, Springer-Verlag GmbH Germany. 2018 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00316768_v470_n1_p155_Marengo http://hdl.handle.net/20.500.12110/paper_00316768_v470_n1_p155_Marengo |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Catecholamines Chromaffin cells Exocytosis Vesicle pools Voltage-dependent Ca2+ channels calcium channel Munc13 protein Munc18 protein myosin adenosine triphosphatase protein SNARE protein synaptotagmin I unclassified drug calcium channel vesicular transport protein adrenal chromaffin cell calcium signaling cell fusion cell membrane chromaffin granule exocytosis nonhuman priority journal Review secretory granule stimulus adrenal medulla animal human metabolism secretion (process) Adrenal Medulla Animals Calcium Channels Chromaffin Granules Exocytosis Humans Vesicular Transport Proteins |
| spellingShingle |
Catecholamines Chromaffin cells Exocytosis Vesicle pools Voltage-dependent Ca2+ channels calcium channel Munc13 protein Munc18 protein myosin adenosine triphosphatase protein SNARE protein synaptotagmin I unclassified drug calcium channel vesicular transport protein adrenal chromaffin cell calcium signaling cell fusion cell membrane chromaffin granule exocytosis nonhuman priority journal Review secretory granule stimulus adrenal medulla animal human metabolism secretion (process) Adrenal Medulla Animals Calcium Channels Chromaffin Granules Exocytosis Humans Vesicular Transport Proteins How does the stimulus define exocytosis in adrenal chromaffin cells? |
| topic_facet |
Catecholamines Chromaffin cells Exocytosis Vesicle pools Voltage-dependent Ca2+ channels calcium channel Munc13 protein Munc18 protein myosin adenosine triphosphatase protein SNARE protein synaptotagmin I unclassified drug calcium channel vesicular transport protein adrenal chromaffin cell calcium signaling cell fusion cell membrane chromaffin granule exocytosis nonhuman priority journal Review secretory granule stimulus adrenal medulla animal human metabolism secretion (process) Adrenal Medulla Animals Calcium Channels Chromaffin Granules Exocytosis Humans Vesicular Transport Proteins |
| description |
The extent and type of hormones and active peptides secreted by the chromaffin cells of the adrenal medulla have to be adjusted to physiological requirements. The chromaffin cell secretory activity is controlled by the splanchnic nerve firing frequency, which goes from approximately 0.5 Hz in basal conditions to more than 15 Hz in stress. Thus, these neuroendocrine cells maintain a tonic release of catecholamines under resting conditions, massively discharge intravesicular transmitters in response to stress, or adequately respond to moderate stimuli. In order to adjust the secretory response to the stimulus, the adrenal chromaffin cells have an appropriate organization of Ca2+ channels, secretory granules pools, and sets of proteins dedicated to selectively control different steps of the secretion process, such as the traffic, docking, priming and fusion of the chromaffin granules. Among the molecules implicated in such events are the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins, Ca2+ sensors like Munc13 and synaptotagmin-1, chaperon proteins such as Munc18, and the actomyosin complex. In the present review, we discuss how these different actors contribute to the extent and maintenance of the stimulus-dependent exocytosis in the adrenal chromaffin cells. © 2017, Springer-Verlag GmbH Germany. |
| title |
How does the stimulus define exocytosis in adrenal chromaffin cells? |
| title_short |
How does the stimulus define exocytosis in adrenal chromaffin cells? |
| title_full |
How does the stimulus define exocytosis in adrenal chromaffin cells? |
| title_fullStr |
How does the stimulus define exocytosis in adrenal chromaffin cells? |
| title_full_unstemmed |
How does the stimulus define exocytosis in adrenal chromaffin cells? |
| title_sort |
how does the stimulus define exocytosis in adrenal chromaffin cells? |
| publishDate |
2018 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00316768_v470_n1_p155_Marengo http://hdl.handle.net/20.500.12110/paper_00316768_v470_n1_p155_Marengo |
| _version_ |
1768545499480064000 |