Respiratory disturbances during sleep in syringomyelia and syringobulbia
Objective: To determine the frequency and types of abnormalities of respiratory control during sleep in syringomyelia and syringobulbia and to provide a basis to predict patients at risk of sudden death. Methods: Thirty patients (15 male and 15 female; mean age 39.0 ± 12.6 years) with communicating...
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1999
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00283878_v52_n9_p1777_Nogues http://hdl.handle.net/20.500.12110/paper_00283878_v52_n9_p1777_Nogues |
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paper:paper_00283878_v52_n9_p1777_Nogues2023-06-08T14:55:08Z Respiratory disturbances during sleep in syringomyelia and syringobulbia adolescent adult aged article clinical article controlled study dysphagia dysphonia female human lung function male medulla oblongata polysomnography priority journal respiration center respiratory failure sleep sudden death syringomyelia Adolescent Adult Aged Brain Female Humans Magnetic Resonance Imaging Male Middle Aged Polysomnography Respiration Disorders Sleep Syringomyelia Objective: To determine the frequency and types of abnormalities of respiratory control during sleep in syringomyelia and syringobulbia and to provide a basis to predict patients at risk of sudden death. Methods: Thirty patients (15 male and 15 female; mean age 39.0 ± 12.6 years) with communicating syringomyelia were divided into two groups: those with evidence of syringobulbia (17 patients) and those without compromise of the medulla or syringomyelia (13 patients). Patients were studied with pulmonary function studies and polysomnography. Respiratory center sensitivity to CO2 (rebreathing technique) was measured in 9 patients. Results: Severely affected patients had mild-to-moderate restriction and individual patients had bilateral diaphragmatic or vocal cord palsy, abnormal respiratory rhythm, prolonged inspiratory time, or an abnormal respiratory response to CO2. Very prolonged central, obstructive, and mixed sleep apneas with low O2 saturation values and a fixed heart rate were recorded in most patients with syringobulbia. Five patients developed severe respiratory complications and died during a follow-up period of 10 years. Respiratory abnormalities failed to correlate with syrinx size. Conclusions: Severe abnormalities in respiratory rhythm generation during sleep occur in patients with syringobulbia. The respiratory disturbances are not due to muscle weakness and they are not correlated with the size of the cavity. The combination of dysphagia and dysphonia in patients with longstanding syringomyelia and syringobulbia predicted likelihood of respiratory disturbances during sleep. 1999 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00283878_v52_n9_p1777_Nogues http://hdl.handle.net/20.500.12110/paper_00283878_v52_n9_p1777_Nogues |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
adolescent adult aged article clinical article controlled study dysphagia dysphonia female human lung function male medulla oblongata polysomnography priority journal respiration center respiratory failure sleep sudden death syringomyelia Adolescent Adult Aged Brain Female Humans Magnetic Resonance Imaging Male Middle Aged Polysomnography Respiration Disorders Sleep Syringomyelia |
| spellingShingle |
adolescent adult aged article clinical article controlled study dysphagia dysphonia female human lung function male medulla oblongata polysomnography priority journal respiration center respiratory failure sleep sudden death syringomyelia Adolescent Adult Aged Brain Female Humans Magnetic Resonance Imaging Male Middle Aged Polysomnography Respiration Disorders Sleep Syringomyelia Respiratory disturbances during sleep in syringomyelia and syringobulbia |
| topic_facet |
adolescent adult aged article clinical article controlled study dysphagia dysphonia female human lung function male medulla oblongata polysomnography priority journal respiration center respiratory failure sleep sudden death syringomyelia Adolescent Adult Aged Brain Female Humans Magnetic Resonance Imaging Male Middle Aged Polysomnography Respiration Disorders Sleep Syringomyelia |
| description |
Objective: To determine the frequency and types of abnormalities of respiratory control during sleep in syringomyelia and syringobulbia and to provide a basis to predict patients at risk of sudden death. Methods: Thirty patients (15 male and 15 female; mean age 39.0 ± 12.6 years) with communicating syringomyelia were divided into two groups: those with evidence of syringobulbia (17 patients) and those without compromise of the medulla or syringomyelia (13 patients). Patients were studied with pulmonary function studies and polysomnography. Respiratory center sensitivity to CO2 (rebreathing technique) was measured in 9 patients. Results: Severely affected patients had mild-to-moderate restriction and individual patients had bilateral diaphragmatic or vocal cord palsy, abnormal respiratory rhythm, prolonged inspiratory time, or an abnormal respiratory response to CO2. Very prolonged central, obstructive, and mixed sleep apneas with low O2 saturation values and a fixed heart rate were recorded in most patients with syringobulbia. Five patients developed severe respiratory complications and died during a follow-up period of 10 years. Respiratory abnormalities failed to correlate with syrinx size. Conclusions: Severe abnormalities in respiratory rhythm generation during sleep occur in patients with syringobulbia. The respiratory disturbances are not due to muscle weakness and they are not correlated with the size of the cavity. The combination of dysphagia and dysphonia in patients with longstanding syringomyelia and syringobulbia predicted likelihood of respiratory disturbances during sleep. |
| title |
Respiratory disturbances during sleep in syringomyelia and syringobulbia |
| title_short |
Respiratory disturbances during sleep in syringomyelia and syringobulbia |
| title_full |
Respiratory disturbances during sleep in syringomyelia and syringobulbia |
| title_fullStr |
Respiratory disturbances during sleep in syringomyelia and syringobulbia |
| title_full_unstemmed |
Respiratory disturbances during sleep in syringomyelia and syringobulbia |
| title_sort |
respiratory disturbances during sleep in syringomyelia and syringobulbia |
| publishDate |
1999 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00283878_v52_n9_p1777_Nogues http://hdl.handle.net/20.500.12110/paper_00283878_v52_n9_p1777_Nogues |
| _version_ |
1768543548450275328 |