Metabolism of 3H-noradrenaline released from isolated rat hypothalamus by extracts of black widow spider glands

In the isolated rat hypothalamus preincubated with 3H-noradrenaline, an extract from the venom glands of Latrodectus mactans elicited an overflow of tritium which consisted of 70-71% 3H-noradrenaline and 18% 3H-3,4-dihydroxyphenylglycol. Exposure to cocaine or pargyline diminished the formation of 3...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado: 1980
Materias:
Black widow spider venom
Noradrenaline metabolism
Rat hypothalamus
calcium
cocaine
nicotine
noradrenalin
pargyline
radioisotope
spider venom
tetrodotoxin
tyramine
arthropod venom
animal experiment
arthropod
central nervous system
controlled study
drug response
hypothalamus
in vitro study
metabolism
noradrenalin h 3
noradrenergic system
rat
animal
article
spider
Animal
Arthropod Venoms
Black Widow Spider
Hypothalamus
In Vitro
Norepinephrine
Rats
Spider Venoms
Support, Non-U.S. Gov't
Tetrodotoxin
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00281298_v313_n1_p27_FernandezPardal
http://hdl.handle.net/20.500.12110/paper_00281298_v313_n1_p27_FernandezPardal
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
Descripción
Sumario:In the isolated rat hypothalamus preincubated with 3H-noradrenaline, an extract from the venom glands of Latrodectus mactans elicited an overflow of tritium which consisted of 70-71% 3H-noradrenaline and 18% 3H-3,4-dihydroxyphenylglycol. Exposure to cocaine or pargyline diminished the formation of 3H-3,4-dihydroxyphenylglycol, suggesting that the glycol is formed presynaptically after neuronal reuptake of the transmitter released by the venom. Our data suggest that the venom depolarizes the noradrenergic neurones of rat hypothalamus, and that the depolarization leads to calcium-dependent release of 3H-noradrenaline. © 1980 Springer-Verlag.

Ejemplares similares