Metabolism of 3H-noradrenaline released from isolated rat hypothalamus by extracts of black widow spider glands
In the isolated rat hypothalamus preincubated with 3H-noradrenaline, an extract from the venom glands of Latrodectus mactans elicited an overflow of tritium which consisted of 70-71% 3H-noradrenaline and 18% 3H-3,4-dihydroxyphenylglycol. Exposure to cocaine or pargyline diminished the formation of 3...
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1980
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00281298_v313_n1_p27_FernandezPardal http://hdl.handle.net/20.500.12110/paper_00281298_v313_n1_p27_FernandezPardal |
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paper:paper_00281298_v313_n1_p27_FernandezPardal |
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paper:paper_00281298_v313_n1_p27_FernandezPardal2023-06-08T14:54:52Z Metabolism of 3H-noradrenaline released from isolated rat hypothalamus by extracts of black widow spider glands Black widow spider venom Noradrenaline metabolism Rat hypothalamus calcium cocaine nicotine noradrenalin pargyline radioisotope spider venom tetrodotoxin tyramine arthropod venom noradrenalin spider venom tetrodotoxin animal experiment arthropod central nervous system controlled study drug response hypothalamus in vitro study metabolism noradrenalin h 3 noradrenergic system rat animal article hypothalamus metabolism spider Animal Arthropod Venoms Black Widow Spider Hypothalamus In Vitro Norepinephrine Rats Spider Venoms Support, Non-U.S. Gov't Tetrodotoxin In the isolated rat hypothalamus preincubated with 3H-noradrenaline, an extract from the venom glands of Latrodectus mactans elicited an overflow of tritium which consisted of 70-71% 3H-noradrenaline and 18% 3H-3,4-dihydroxyphenylglycol. Exposure to cocaine or pargyline diminished the formation of 3H-3,4-dihydroxyphenylglycol, suggesting that the glycol is formed presynaptically after neuronal reuptake of the transmitter released by the venom. Our data suggest that the venom depolarizes the noradrenergic neurones of rat hypothalamus, and that the depolarization leads to calcium-dependent release of 3H-noradrenaline. © 1980 Springer-Verlag. 1980 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00281298_v313_n1_p27_FernandezPardal http://hdl.handle.net/20.500.12110/paper_00281298_v313_n1_p27_FernandezPardal |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Black widow spider venom Noradrenaline metabolism Rat hypothalamus calcium cocaine nicotine noradrenalin pargyline radioisotope spider venom tetrodotoxin tyramine arthropod venom noradrenalin spider venom tetrodotoxin animal experiment arthropod central nervous system controlled study drug response hypothalamus in vitro study metabolism noradrenalin h 3 noradrenergic system rat animal article hypothalamus metabolism spider Animal Arthropod Venoms Black Widow Spider Hypothalamus In Vitro Norepinephrine Rats Spider Venoms Support, Non-U.S. Gov't Tetrodotoxin |
| spellingShingle |
Black widow spider venom Noradrenaline metabolism Rat hypothalamus calcium cocaine nicotine noradrenalin pargyline radioisotope spider venom tetrodotoxin tyramine arthropod venom noradrenalin spider venom tetrodotoxin animal experiment arthropod central nervous system controlled study drug response hypothalamus in vitro study metabolism noradrenalin h 3 noradrenergic system rat animal article hypothalamus metabolism spider Animal Arthropod Venoms Black Widow Spider Hypothalamus In Vitro Norepinephrine Rats Spider Venoms Support, Non-U.S. Gov't Tetrodotoxin Metabolism of 3H-noradrenaline released from isolated rat hypothalamus by extracts of black widow spider glands |
| topic_facet |
Black widow spider venom Noradrenaline metabolism Rat hypothalamus calcium cocaine nicotine noradrenalin pargyline radioisotope spider venom tetrodotoxin tyramine arthropod venom noradrenalin spider venom tetrodotoxin animal experiment arthropod central nervous system controlled study drug response hypothalamus in vitro study metabolism noradrenalin h 3 noradrenergic system rat animal article hypothalamus metabolism spider Animal Arthropod Venoms Black Widow Spider Hypothalamus In Vitro Norepinephrine Rats Spider Venoms Support, Non-U.S. Gov't Tetrodotoxin |
| description |
In the isolated rat hypothalamus preincubated with 3H-noradrenaline, an extract from the venom glands of Latrodectus mactans elicited an overflow of tritium which consisted of 70-71% 3H-noradrenaline and 18% 3H-3,4-dihydroxyphenylglycol. Exposure to cocaine or pargyline diminished the formation of 3H-3,4-dihydroxyphenylglycol, suggesting that the glycol is formed presynaptically after neuronal reuptake of the transmitter released by the venom. Our data suggest that the venom depolarizes the noradrenergic neurones of rat hypothalamus, and that the depolarization leads to calcium-dependent release of 3H-noradrenaline. © 1980 Springer-Verlag. |
| title |
Metabolism of 3H-noradrenaline released from isolated rat hypothalamus by extracts of black widow spider glands |
| title_short |
Metabolism of 3H-noradrenaline released from isolated rat hypothalamus by extracts of black widow spider glands |
| title_full |
Metabolism of 3H-noradrenaline released from isolated rat hypothalamus by extracts of black widow spider glands |
| title_fullStr |
Metabolism of 3H-noradrenaline released from isolated rat hypothalamus by extracts of black widow spider glands |
| title_full_unstemmed |
Metabolism of 3H-noradrenaline released from isolated rat hypothalamus by extracts of black widow spider glands |
| title_sort |
metabolism of 3h-noradrenaline released from isolated rat hypothalamus by extracts of black widow spider glands |
| publishDate |
1980 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00281298_v313_n1_p27_FernandezPardal http://hdl.handle.net/20.500.12110/paper_00281298_v313_n1_p27_FernandezPardal |
| _version_ |
1768544167183515648 |