Radiation protection by cyanide of both rats and mice

MANY investigators have found1-4 that the rat, unlike the mouse, is afforded little or no protection to irradiation damage by the prior administration of cyanide salts. In all their experiments, a limited dose-range of cyanide was tested. The frequently cited results of Dowdy et al.1, for example, w...

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Publicado:	1963
Materias:	cyanide radioprotective agent article CYANIDES RADIATION-PROTECTIVE AGENTS Cyanides Radiation-Protective Agents
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00280836_v197_n4865_p399_Schubert http://hdl.handle.net/20.500.12110/paper_00280836_v197_n4865_p399_Schubert
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00280836_v197_n4865_p399_Schubert
record_format	dspace
spelling	paper:paper_00280836_v197_n4865_p399_Schubert2023-06-08T14:54:41Z Radiation protection by cyanide of both rats and mice cyanide radioprotective agent article CYANIDES RADIATION-PROTECTIVE AGENTS Cyanides Radiation-Protective Agents MANY investigators have found1-4 that the rat, unlike the mouse, is afforded little or no protection to irradiation damage by the prior administration of cyanide salts. In all their experiments, a limited dose-range of cyanide was tested. The frequently cited results of Dowdy et al.1, for example, were obtained using a single dose (3 mg/kg) of sodium cyanide. A recent theory5 states that compounds such as cyanide and azide owe their radiobiological action to the property of stabilization of cuprous (Cu I) ion involved in oxidative processes. The proposal suggests that the dose required to achieve protection would be sharply defined and, if not limited by chemical toxicity of cyanide, it should be possible to demonstrate protection in the rat using the proper dose. Accordingly, survival was compared in rats and mice given a wide range of doses of sodium cyanide prior to X-irradiation. © 1963 Nature Publishing Group. 1963 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00280836_v197_n4865_p399_Schubert http://hdl.handle.net/20.500.12110/paper_00280836_v197_n4865_p399_Schubert
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	cyanide radioprotective agent article CYANIDES RADIATION-PROTECTIVE AGENTS Cyanides Radiation-Protective Agents
spellingShingle	cyanide radioprotective agent article CYANIDES RADIATION-PROTECTIVE AGENTS Cyanides Radiation-Protective Agents Radiation protection by cyanide of both rats and mice
topic_facet	cyanide radioprotective agent article CYANIDES RADIATION-PROTECTIVE AGENTS Cyanides Radiation-Protective Agents
description	MANY investigators have found1-4 that the rat, unlike the mouse, is afforded little or no protection to irradiation damage by the prior administration of cyanide salts. In all their experiments, a limited dose-range of cyanide was tested. The frequently cited results of Dowdy et al.1, for example, were obtained using a single dose (3 mg/kg) of sodium cyanide. A recent theory5 states that compounds such as cyanide and azide owe their radiobiological action to the property of stabilization of cuprous (Cu I) ion involved in oxidative processes. The proposal suggests that the dose required to achieve protection would be sharply defined and, if not limited by chemical toxicity of cyanide, it should be possible to demonstrate protection in the rat using the proper dose. Accordingly, survival was compared in rats and mice given a wide range of doses of sodium cyanide prior to X-irradiation. © 1963 Nature Publishing Group.
title	Radiation protection by cyanide of both rats and mice
title_short	Radiation protection by cyanide of both rats and mice
title_full	Radiation protection by cyanide of both rats and mice
title_fullStr	Radiation protection by cyanide of both rats and mice
title_full_unstemmed	Radiation protection by cyanide of both rats and mice
title_sort	radiation protection by cyanide of both rats and mice
publishDate	1963
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00280836_v197_n4865_p399_Schubert http://hdl.handle.net/20.500.12110/paper_00280836_v197_n4865_p399_Schubert
_version_	1768542447233662976

Radiation protection by cyanide of both rats and mice

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