Utilization of extracellular information before ligand-receptor binding reaches equilibrium expands and shifts the input dynamic range

Cell signaling systems sense and respond to ligands that bind cell surface receptors. These systems often respond to changes in the concentration of extracellular ligand more rapidly than the ligand equilibrates with its receptor. We demonstrate, by modeling and experiment, a general "systems l...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ventura, Alejandra C., Bush, Alan, Chernomoretz, Ariel, Colman Lerner, Alejandro Ariel
Publicado:	2014
Materias:	cell surface receptor ligand protein binding biological model cell polarity cytology extracellular space kinetics metabolism Saccharomyces cerevisiae signal transduction time Cell Polarity Extracellular Space Kinetics Ligands Models, Biological Protein Binding Receptors, Cell Surface Signal Transduction Time Factors
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00278424_v111_n37_pE3860_Ventura http://hdl.handle.net/20.500.12110/paper_00278424_v111_n37_pE3860_Ventura
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00278424_v111_n37_pE3860_Ventura
record_format	dspace
spelling	paper:paper_00278424_v111_n37_pE3860_Ventura2023-06-08T14:54:30Z Utilization of extracellular information before ligand-receptor binding reaches equilibrium expands and shifts the input dynamic range Ventura, Alejandra C. Bush, Alan Chernomoretz, Ariel Colman Lerner, Alejandro Ariel cell surface receptor ligand protein binding biological model cell polarity cytology extracellular space kinetics metabolism Saccharomyces cerevisiae signal transduction time Cell Polarity Extracellular Space Kinetics Ligands Models, Biological Protein Binding Receptors, Cell Surface Saccharomyces cerevisiae Signal Transduction Time Factors Cell signaling systems sense and respond to ligands that bind cell surface receptors. These systems often respond to changes in the concentration of extracellular ligand more rapidly than the ligand equilibrates with its receptor. We demonstrate, by modeling and experiment, a general "systems level" mechanism cells use to take advantage of the information present in the early signal, before receptor binding reaches a new steady state. This mechanism, preequilibrium sensing and signaling (PRESS), operates in signaling systems inwhich the kinetics of ligand-receptor binding are slower than the downstream signaling steps, and it typically involves transient activation of a downstream step. In the systems where it operates, PRESS expands and shifts the input dynamic range, allowing cells to make different responses to ligand concentrations so high as to be otherwise indistinguishable. Specifically, we show that PRESS applies to the yeast directional polarization in response to pheromone gradients. Consideration of preexisting kinetic data for ligand-receptor interactions suggests that PRESS operates in many cell signaling systems throughout biology. The same mechanism may also operate at other levels in signaling systems in which a slow activation step couples to a faster downstream step. Fil:Ventura, A.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Bush, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Chernomoretz, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Colman-Lerner, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00278424_v111_n37_pE3860_Ventura http://hdl.handle.net/20.500.12110/paper_00278424_v111_n37_pE3860_Ventura
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	cell surface receptor ligand protein binding biological model cell polarity cytology extracellular space kinetics metabolism Saccharomyces cerevisiae signal transduction time Cell Polarity Extracellular Space Kinetics Ligands Models, Biological Protein Binding Receptors, Cell Surface Saccharomyces cerevisiae Signal Transduction Time Factors
spellingShingle	cell surface receptor ligand protein binding biological model cell polarity cytology extracellular space kinetics metabolism Saccharomyces cerevisiae signal transduction time Cell Polarity Extracellular Space Kinetics Ligands Models, Biological Protein Binding Receptors, Cell Surface Saccharomyces cerevisiae Signal Transduction Time Factors Ventura, Alejandra C. Bush, Alan Chernomoretz, Ariel Colman Lerner, Alejandro Ariel Utilization of extracellular information before ligand-receptor binding reaches equilibrium expands and shifts the input dynamic range
topic_facet	cell surface receptor ligand protein binding biological model cell polarity cytology extracellular space kinetics metabolism Saccharomyces cerevisiae signal transduction time Cell Polarity Extracellular Space Kinetics Ligands Models, Biological Protein Binding Receptors, Cell Surface Saccharomyces cerevisiae Signal Transduction Time Factors
description	Cell signaling systems sense and respond to ligands that bind cell surface receptors. These systems often respond to changes in the concentration of extracellular ligand more rapidly than the ligand equilibrates with its receptor. We demonstrate, by modeling and experiment, a general "systems level" mechanism cells use to take advantage of the information present in the early signal, before receptor binding reaches a new steady state. This mechanism, preequilibrium sensing and signaling (PRESS), operates in signaling systems inwhich the kinetics of ligand-receptor binding are slower than the downstream signaling steps, and it typically involves transient activation of a downstream step. In the systems where it operates, PRESS expands and shifts the input dynamic range, allowing cells to make different responses to ligand concentrations so high as to be otherwise indistinguishable. Specifically, we show that PRESS applies to the yeast directional polarization in response to pheromone gradients. Consideration of preexisting kinetic data for ligand-receptor interactions suggests that PRESS operates in many cell signaling systems throughout biology. The same mechanism may also operate at other levels in signaling systems in which a slow activation step couples to a faster downstream step.
author	Ventura, Alejandra C. Bush, Alan Chernomoretz, Ariel Colman Lerner, Alejandro Ariel
author_facet	Ventura, Alejandra C. Bush, Alan Chernomoretz, Ariel Colman Lerner, Alejandro Ariel
author_sort	Ventura, Alejandra C.
title	Utilization of extracellular information before ligand-receptor binding reaches equilibrium expands and shifts the input dynamic range
title_short	Utilization of extracellular information before ligand-receptor binding reaches equilibrium expands and shifts the input dynamic range
title_full	Utilization of extracellular information before ligand-receptor binding reaches equilibrium expands and shifts the input dynamic range
title_fullStr	Utilization of extracellular information before ligand-receptor binding reaches equilibrium expands and shifts the input dynamic range
title_full_unstemmed	Utilization of extracellular information before ligand-receptor binding reaches equilibrium expands and shifts the input dynamic range
title_sort	utilization of extracellular information before ligand-receptor binding reaches equilibrium expands and shifts the input dynamic range
publishDate	2014
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00278424_v111_n37_pE3860_Ventura http://hdl.handle.net/20.500.12110/paper_00278424_v111_n37_pE3860_Ventura
work_keys_str_mv	AT venturaalejandrac utilizationofextracellularinformationbeforeligandreceptorbindingreachesequilibriumexpandsandshiftstheinputdynamicrange AT bushalan utilizationofextracellularinformationbeforeligandreceptorbindingreachesequilibriumexpandsandshiftstheinputdynamicrange AT chernomoretzariel utilizationofextracellularinformationbeforeligandreceptorbindingreachesequilibriumexpandsandshiftstheinputdynamicrange AT colmanlerneralejandroariel utilizationofextracellularinformationbeforeligandreceptorbindingreachesequilibriumexpandsandshiftstheinputdynamicrange
_version_	1768546710430154752

Utilization of extracellular information before ligand-receptor binding reaches equilibrium expands and shifts the input dynamic range

Ejemplares similares