Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia
Preeclampsia (PE) is a pregnancy-specific disorder characterized by sudden onset of hypertension and proteinuria in the second half of pregnancy (>20 wk). PE is strongly associated with abnormal placentation and an excessive maternal inflammatory response. Galectin-1 (Gal-1), a member of a family...
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2013
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00278424_v110_n28_p11451_Freitag http://hdl.handle.net/20.500.12110/paper_00278424_v110_n28_p11451_Freitag |
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paper:paper_00278424_v110_n28_p11451_Freitag2023-06-08T14:54:28Z Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia galectin 1 lectin messenger RNA vasculotropin receptor 1 vasculotropin receptor 2 angiogenesis animal experiment animal tissue article cell adhesion decidua dendritic cell down regulation female gene expression mouse nonhuman preeclampsia pregnancy priority journal signal transduction Animals Disease Models, Animal Female Galectin 1 Humans Mice Neovascularization, Physiologic Placenta Pre-Eclampsia Pregnancy Trophoblasts Mus Preeclampsia (PE) is a pregnancy-specific disorder characterized by sudden onset of hypertension and proteinuria in the second half of pregnancy (>20 wk). PE is strongly associated with abnormal placentation and an excessive maternal inflammatory response. Galectin-1 (Gal-1), a member of a family of carbohydrate-binding proteins, has been shown to modulate several processes associated with placentation and to promote maternal tolerance toward fetal antigens. Here, we show that Gal-1 exhibits proangiogenic functions during early stages of pregnancy, promoting decidual vascular expansion through VEGF receptor 2 signaling. Blocking Gal-1-mediated angiogenesis or lectin, galactoside-binding, soluble, 1 deficiency results in a spontaneous PE-like syndrome in mice, mainly by deregulating processes associated with good placentation and maternal spiral artery remodeling. Consistent with these findings, we observed a down-regulation of Gal-1 in patients suffering from early onset PE. Collectively, these results strengthen the notion that Gal-1 is required for healthy gestation and highlight Gal-1 as a valuable biomarker for early PE diagnosis. 2013 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00278424_v110_n28_p11451_Freitag http://hdl.handle.net/20.500.12110/paper_00278424_v110_n28_p11451_Freitag |
| institution |
Universidad de Buenos Aires |
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I-28 |
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R-134 |
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Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
galectin 1 lectin messenger RNA vasculotropin receptor 1 vasculotropin receptor 2 angiogenesis animal experiment animal tissue article cell adhesion decidua dendritic cell down regulation female gene expression mouse nonhuman preeclampsia pregnancy priority journal signal transduction Animals Disease Models, Animal Female Galectin 1 Humans Mice Neovascularization, Physiologic Placenta Pre-Eclampsia Pregnancy Trophoblasts Mus |
| spellingShingle |
galectin 1 lectin messenger RNA vasculotropin receptor 1 vasculotropin receptor 2 angiogenesis animal experiment animal tissue article cell adhesion decidua dendritic cell down regulation female gene expression mouse nonhuman preeclampsia pregnancy priority journal signal transduction Animals Disease Models, Animal Female Galectin 1 Humans Mice Neovascularization, Physiologic Placenta Pre-Eclampsia Pregnancy Trophoblasts Mus Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia |
| topic_facet |
galectin 1 lectin messenger RNA vasculotropin receptor 1 vasculotropin receptor 2 angiogenesis animal experiment animal tissue article cell adhesion decidua dendritic cell down regulation female gene expression mouse nonhuman preeclampsia pregnancy priority journal signal transduction Animals Disease Models, Animal Female Galectin 1 Humans Mice Neovascularization, Physiologic Placenta Pre-Eclampsia Pregnancy Trophoblasts Mus |
| description |
Preeclampsia (PE) is a pregnancy-specific disorder characterized by sudden onset of hypertension and proteinuria in the second half of pregnancy (>20 wk). PE is strongly associated with abnormal placentation and an excessive maternal inflammatory response. Galectin-1 (Gal-1), a member of a family of carbohydrate-binding proteins, has been shown to modulate several processes associated with placentation and to promote maternal tolerance toward fetal antigens. Here, we show that Gal-1 exhibits proangiogenic functions during early stages of pregnancy, promoting decidual vascular expansion through VEGF receptor 2 signaling. Blocking Gal-1-mediated angiogenesis or lectin, galactoside-binding, soluble, 1 deficiency results in a spontaneous PE-like syndrome in mice, mainly by deregulating processes associated with good placentation and maternal spiral artery remodeling. Consistent with these findings, we observed a down-regulation of Gal-1 in patients suffering from early onset PE. Collectively, these results strengthen the notion that Gal-1 is required for healthy gestation and highlight Gal-1 as a valuable biomarker for early PE diagnosis. |
| title |
Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia |
| title_short |
Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia |
| title_full |
Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia |
| title_fullStr |
Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia |
| title_full_unstemmed |
Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia |
| title_sort |
interfering with gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia |
| publishDate |
2013 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00278424_v110_n28_p11451_Freitag http://hdl.handle.net/20.500.12110/paper_00278424_v110_n28_p11451_Freitag |
| _version_ |
1768546664938733568 |