Conserved regulatory architecture underlies parallel genetic changes and convergent phenotypic evolution
Similar morphological, physiological, and behavioral features have evolved independently in different species, a pattern known as convergence. It is known that morphological convergence can occur through changes in orthologous genes. In some cases of convergence, cis-regulatory changes generate para...
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2012
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00278424_v109_n51_p20975_Frankel http://hdl.handle.net/20.500.12110/paper_00278424_v109_n51_p20975_Frankel |
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paper:paper_00278424_v109_n51_p20975_Frankel2023-06-08T14:54:28Z Conserved regulatory architecture underlies parallel genetic changes and convergent phenotypic evolution Enhancer function Evolutionary developmental biology Parallel developmental evolution article cell lineage Drosophila gene expression gene locus genetic analysis genetic transcription molecular evolution nonhuman phenotype priority journal Animals Developmental Biology Drosophila Drosophila melanogaster Enhancer Elements, Genetic Evolution, Molecular Gene Expression Regulation Genes, Reporter Genetic Vectors Models, Genetic Molecular Sequence Data Phenotype Species Specificity Transcription, Genetic Drosophila ezoana Drosophila sechellia Mya Spondias purpurea Similar morphological, physiological, and behavioral features have evolved independently in different species, a pattern known as convergence. It is known that morphological convergence can occur through changes in orthologous genes. In some cases of convergence, cis-regulatory changes generate parallel modifications in the expression patterns of orthologous genes. Our understanding of how changes in cis-regulatory regions contribute to convergence is hampered, usually, by a limited understanding of the global cis-regulatory structure of the evolving genes. Here we examine the genetic causes of a case of precise phenotypic convergence between Drosophila sechellia and Drosophila ezoana, species that diverged ?40 Mya. Previous studies revealed that changes in multiple transcriptional enhancers of shavenbaby (svb, a transcript of the ovo locus) caused phenotypic evolution in the D. sechellia lineage. It has also been shown that the convergent phenotype of D. ezoana was likely caused by cis-regulatory evolution of svb. Here we show that the large-scale cis-regulatory architecture of svb is conserved between these Drosophila species. Furthermore, we show that the D. ezoana orthologs of the evolved D. sechellia enhancers have also evolved expression patterns that correlate precisely with the changes in the phenotype. Our results suggest that phenotypic convergence resulted frommultiple noncoding changes that occurred in parallel in the D. sechellia and D. ezoana lineages. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00278424_v109_n51_p20975_Frankel http://hdl.handle.net/20.500.12110/paper_00278424_v109_n51_p20975_Frankel |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Enhancer function Evolutionary developmental biology Parallel developmental evolution article cell lineage Drosophila gene expression gene locus genetic analysis genetic transcription molecular evolution nonhuman phenotype priority journal Animals Developmental Biology Drosophila Drosophila melanogaster Enhancer Elements, Genetic Evolution, Molecular Gene Expression Regulation Genes, Reporter Genetic Vectors Models, Genetic Molecular Sequence Data Phenotype Species Specificity Transcription, Genetic Drosophila ezoana Drosophila sechellia Mya Spondias purpurea |
| spellingShingle |
Enhancer function Evolutionary developmental biology Parallel developmental evolution article cell lineage Drosophila gene expression gene locus genetic analysis genetic transcription molecular evolution nonhuman phenotype priority journal Animals Developmental Biology Drosophila Drosophila melanogaster Enhancer Elements, Genetic Evolution, Molecular Gene Expression Regulation Genes, Reporter Genetic Vectors Models, Genetic Molecular Sequence Data Phenotype Species Specificity Transcription, Genetic Drosophila ezoana Drosophila sechellia Mya Spondias purpurea Conserved regulatory architecture underlies parallel genetic changes and convergent phenotypic evolution |
| topic_facet |
Enhancer function Evolutionary developmental biology Parallel developmental evolution article cell lineage Drosophila gene expression gene locus genetic analysis genetic transcription molecular evolution nonhuman phenotype priority journal Animals Developmental Biology Drosophila Drosophila melanogaster Enhancer Elements, Genetic Evolution, Molecular Gene Expression Regulation Genes, Reporter Genetic Vectors Models, Genetic Molecular Sequence Data Phenotype Species Specificity Transcription, Genetic Drosophila ezoana Drosophila sechellia Mya Spondias purpurea |
| description |
Similar morphological, physiological, and behavioral features have evolved independently in different species, a pattern known as convergence. It is known that morphological convergence can occur through changes in orthologous genes. In some cases of convergence, cis-regulatory changes generate parallel modifications in the expression patterns of orthologous genes. Our understanding of how changes in cis-regulatory regions contribute to convergence is hampered, usually, by a limited understanding of the global cis-regulatory structure of the evolving genes. Here we examine the genetic causes of a case of precise phenotypic convergence between Drosophila sechellia and Drosophila ezoana, species that diverged ?40 Mya. Previous studies revealed that changes in multiple transcriptional enhancers of shavenbaby (svb, a transcript of the ovo locus) caused phenotypic evolution in the D. sechellia lineage. It has also been shown that the convergent phenotype of D. ezoana was likely caused by cis-regulatory evolution of svb. Here we show that the large-scale cis-regulatory architecture of svb is conserved between these Drosophila species. Furthermore, we show that the D. ezoana orthologs of the evolved D. sechellia enhancers have also evolved expression patterns that correlate precisely with the changes in the phenotype. Our results suggest that phenotypic convergence resulted frommultiple noncoding changes that occurred in parallel in the D. sechellia and D. ezoana lineages. |
| title |
Conserved regulatory architecture underlies parallel genetic changes and convergent phenotypic evolution |
| title_short |
Conserved regulatory architecture underlies parallel genetic changes and convergent phenotypic evolution |
| title_full |
Conserved regulatory architecture underlies parallel genetic changes and convergent phenotypic evolution |
| title_fullStr |
Conserved regulatory architecture underlies parallel genetic changes and convergent phenotypic evolution |
| title_full_unstemmed |
Conserved regulatory architecture underlies parallel genetic changes and convergent phenotypic evolution |
| title_sort |
conserved regulatory architecture underlies parallel genetic changes and convergent phenotypic evolution |
| publishDate |
2012 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00278424_v109_n51_p20975_Frankel http://hdl.handle.net/20.500.12110/paper_00278424_v109_n51_p20975_Frankel |
| _version_ |
1768546664745795584 |