Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation
Long-term memory (LTM) consolidation requires the synthesis of plasticity-related proteins (PRPs). In addition, we have shown recently that LTM formation also requires the setting of a "learning tag" able to capture those PRPs. Weak training, which results only in short-term memory, can se...
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2011
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00278424_v108_n31_p12931_Moncada http://hdl.handle.net/20.500.12110/paper_00278424_v108_n31_p12931_Moncada |
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paper:paper_00278424_v108_n31_p12931_Moncada2023-06-08T14:54:25Z Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation Moncada, Diego Martínez, María Cecilia Viola, Haydée Ana María CA1 Dentate gyrus Synaptic tagging beta adrenergic receptor calcium calmodulin dependent protein kinase II dopamine 1 receptor dopamine 5 receptor n methyl dextro aspartic acid receptor neurotransmitter animal experiment article controlled study dopaminergic system dopaminergic transmission long term memory male memory consolidation molecule nonhuman noradrenergic system priority journal protein synthesis rat short term memory 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 2-Amino-5-phosphonovalerate Adrenergic beta-Antagonists Animals Avoidance Learning Benzazepines CA1 Region, Hippocampal Calcium-Calmodulin-Dependent Protein Kinase Type 2 Dobutamine Enzyme Inhibitors Excitatory Amino Acid Antagonists Exploratory Behavior Male Memory, Long-Term Memory, Short-Term Neuronal Plasticity Propranolol Rats Rats, Wistar Receptors, Adrenergic, beta Receptors, Dopamine D1 Receptors, Dopamine D5 Receptors, N-Methyl-D-Aspartate Rattus Long-term memory (LTM) consolidation requires the synthesis of plasticity-related proteins (PRPs). In addition, we have shown recently that LTM formation also requires the setting of a "learning tag" able to capture those PRPs. Weak training, which results only in short-term memory, can set a tag to use PRPs derived from a temporal-spatial closely related event to promote LTM formation. Here, we studied the involvement of glutamatergic, dopaminergic, and noradrenergic inputs on the setting of an inhibitory avoidance (IA) learning tag and the synthesis of PRPs. Rats explored an open field (PRP donor) followed by weak (tag inducer) or strong (tag inducer plus PRP donor) IA training. Throughout pharmacological interventions around open-field and/or IA sessions, we found that hippocampal dopamine D1/D5- and β-adrenergic receptors are specifically required to induce PRP synthesis. Moreover, activation of the glutamatergic NMDA receptors is required for setting the learning tags, and this machinery further required α-Ca 2+/calmodulin-dependent protein kinase II and PKA but not ERK1/2 activity. Together, the present findings emphasize an essential role of the induction of PRPs and learning tags for LTM formation. The existence of only the PRP or the tag was insufficient for stabilization of the mnemonic trace. Fil:Moncada, D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Martinez, M.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Viola, H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2011 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00278424_v108_n31_p12931_Moncada http://hdl.handle.net/20.500.12110/paper_00278424_v108_n31_p12931_Moncada |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
CA1 Dentate gyrus Synaptic tagging beta adrenergic receptor calcium calmodulin dependent protein kinase II dopamine 1 receptor dopamine 5 receptor n methyl dextro aspartic acid receptor neurotransmitter animal experiment article controlled study dopaminergic system dopaminergic transmission long term memory male memory consolidation molecule nonhuman noradrenergic system priority journal protein synthesis rat short term memory 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 2-Amino-5-phosphonovalerate Adrenergic beta-Antagonists Animals Avoidance Learning Benzazepines CA1 Region, Hippocampal Calcium-Calmodulin-Dependent Protein Kinase Type 2 Dobutamine Enzyme Inhibitors Excitatory Amino Acid Antagonists Exploratory Behavior Male Memory, Long-Term Memory, Short-Term Neuronal Plasticity Propranolol Rats Rats, Wistar Receptors, Adrenergic, beta Receptors, Dopamine D1 Receptors, Dopamine D5 Receptors, N-Methyl-D-Aspartate Rattus |
| spellingShingle |
CA1 Dentate gyrus Synaptic tagging beta adrenergic receptor calcium calmodulin dependent protein kinase II dopamine 1 receptor dopamine 5 receptor n methyl dextro aspartic acid receptor neurotransmitter animal experiment article controlled study dopaminergic system dopaminergic transmission long term memory male memory consolidation molecule nonhuman noradrenergic system priority journal protein synthesis rat short term memory 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 2-Amino-5-phosphonovalerate Adrenergic beta-Antagonists Animals Avoidance Learning Benzazepines CA1 Region, Hippocampal Calcium-Calmodulin-Dependent Protein Kinase Type 2 Dobutamine Enzyme Inhibitors Excitatory Amino Acid Antagonists Exploratory Behavior Male Memory, Long-Term Memory, Short-Term Neuronal Plasticity Propranolol Rats Rats, Wistar Receptors, Adrenergic, beta Receptors, Dopamine D1 Receptors, Dopamine D5 Receptors, N-Methyl-D-Aspartate Rattus Moncada, Diego Martínez, María Cecilia Viola, Haydée Ana María Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation |
| topic_facet |
CA1 Dentate gyrus Synaptic tagging beta adrenergic receptor calcium calmodulin dependent protein kinase II dopamine 1 receptor dopamine 5 receptor n methyl dextro aspartic acid receptor neurotransmitter animal experiment article controlled study dopaminergic system dopaminergic transmission long term memory male memory consolidation molecule nonhuman noradrenergic system priority journal protein synthesis rat short term memory 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine 2-Amino-5-phosphonovalerate Adrenergic beta-Antagonists Animals Avoidance Learning Benzazepines CA1 Region, Hippocampal Calcium-Calmodulin-Dependent Protein Kinase Type 2 Dobutamine Enzyme Inhibitors Excitatory Amino Acid Antagonists Exploratory Behavior Male Memory, Long-Term Memory, Short-Term Neuronal Plasticity Propranolol Rats Rats, Wistar Receptors, Adrenergic, beta Receptors, Dopamine D1 Receptors, Dopamine D5 Receptors, N-Methyl-D-Aspartate Rattus |
| description |
Long-term memory (LTM) consolidation requires the synthesis of plasticity-related proteins (PRPs). In addition, we have shown recently that LTM formation also requires the setting of a "learning tag" able to capture those PRPs. Weak training, which results only in short-term memory, can set a tag to use PRPs derived from a temporal-spatial closely related event to promote LTM formation. Here, we studied the involvement of glutamatergic, dopaminergic, and noradrenergic inputs on the setting of an inhibitory avoidance (IA) learning tag and the synthesis of PRPs. Rats explored an open field (PRP donor) followed by weak (tag inducer) or strong (tag inducer plus PRP donor) IA training. Throughout pharmacological interventions around open-field and/or IA sessions, we found that hippocampal dopamine D1/D5- and β-adrenergic receptors are specifically required to induce PRP synthesis. Moreover, activation of the glutamatergic NMDA receptors is required for setting the learning tags, and this machinery further required α-Ca 2+/calmodulin-dependent protein kinase II and PKA but not ERK1/2 activity. Together, the present findings emphasize an essential role of the induction of PRPs and learning tags for LTM formation. The existence of only the PRP or the tag was insufficient for stabilization of the mnemonic trace. |
| author |
Moncada, Diego Martínez, María Cecilia Viola, Haydée Ana María |
| author_facet |
Moncada, Diego Martínez, María Cecilia Viola, Haydée Ana María |
| author_sort |
Moncada, Diego |
| title |
Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation |
| title_short |
Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation |
| title_full |
Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation |
| title_fullStr |
Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation |
| title_full_unstemmed |
Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation |
| title_sort |
identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation |
| publishDate |
2011 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00278424_v108_n31_p12931_Moncada http://hdl.handle.net/20.500.12110/paper_00278424_v108_n31_p12931_Moncada |
| work_keys_str_mv |
AT moncadadiego identificationoftransmittersystemsandlearningtagmoleculesinvolvedinbehavioraltaggingduringmemoryformation AT martinezmariacecilia identificationoftransmittersystemsandlearningtagmoleculesinvolvedinbehavioraltaggingduringmemoryformation AT violahaydeeanamaria identificationoftransmittersystemsandlearningtagmoleculesinvolvedinbehavioraltaggingduringmemoryformation |
| _version_ |
1768544675080175616 |