A natural antiviral and immunomodulatory compound with antiangiogenic properties

Meliacine (MA), an antiviral principle present in partially purified leaf extracts of Melia azedarach L., reduces viral load and abolishes the inflammatory reaction and neovascularization during the development of herpetic stromal keratitis in mice. 1-cinnamoyl-3,11-dihydroxymeliacarpin (CDM), obtai...

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Detalles Bibliográficos
Autores principales:	Bueno, Carlos Alberto, Lombardi, María Gabriela, Alche, Laura Edith
Publicado:	2012
Materias:	1 cinnamoyl 3,11 dihydroxymeliacarpin angiogenesis inhibitor antivirus agent immunomodulating agent interleukin 6 lipopolysaccharide meliacine tumor necrosis factor alpha unclassified drug vasculotropin vasculotropin A animal cell animal experiment animal model antiangiogenic activity antiproliferative activity article cell function cell stimulation cell viability chemotaxis concentration response controlled study cytokine production female Herpes simplex virus 1 human human cell immunomodulation in vitro study in vivo study migration inhibition mouse nonhuman priority journal protein expression umbilical vein endothelial cell Angiogenesis Inhibitors Animals Antiviral Agents Cell Proliferation Chemistry, Pharmaceutical Chemotaxis Drug Design Female Gene Expression Regulation Herpesvirus 1, Human Humans Immunologic Factors Lipopolysaccharides Melia Mice Mice, Inbred BALB C Neoplasms Neovascularization, Pathologic Peptides Plant Extracts Plant Proteins Vascular Endothelial Growth Factor A Human herpesvirus 1 Melia azedarach Murinae Mus
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00262862_v84_n3_p235_Bueno http://hdl.handle.net/20.500.12110/paper_00262862_v84_n3_p235_Bueno
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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