A natural antiviral and immunomodulatory compound with antiangiogenic properties

Meliacine (MA), an antiviral principle present in partially purified leaf extracts of Melia azedarach L., reduces viral load and abolishes the inflammatory reaction and neovascularization during the development of herpetic stromal keratitis in mice. 1-cinnamoyl-3,11-dihydroxymeliacarpin (CDM), obtai...

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Autores principales:	Bueno, Carlos Alberto, Lombardi, María Gabriela, Alche, Laura Edith
Publicado:	2012
Materias:	1 cinnamoyl 3,11 dihydroxymeliacarpin angiogenesis inhibitor antivirus agent immunomodulating agent interleukin 6 lipopolysaccharide meliacine tumor necrosis factor alpha unclassified drug vasculotropin vasculotropin A animal cell animal experiment animal model antiangiogenic activity antiproliferative activity article cell function cell stimulation cell viability chemotaxis concentration response controlled study cytokine production female Herpes simplex virus 1 human human cell immunomodulation in vitro study in vivo study migration inhibition mouse nonhuman priority journal protein expression umbilical vein endothelial cell Angiogenesis Inhibitors Animals Antiviral Agents Cell Proliferation Chemistry, Pharmaceutical Chemotaxis Drug Design Female Gene Expression Regulation Herpesvirus 1, Human Humans Immunologic Factors Lipopolysaccharides Melia Mice Mice, Inbred BALB C Neoplasms Neovascularization, Pathologic Peptides Plant Extracts Plant Proteins Vascular Endothelial Growth Factor A Human herpesvirus 1 Melia azedarach Murinae Mus
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00262862_v84_n3_p235_Bueno http://hdl.handle.net/20.500.12110/paper_00262862_v84_n3_p235_Bueno
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00262862_v84_n3_p235_Bueno
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spelling	paper:paper_00262862_v84_n3_p235_Bueno2023-06-08T14:53:52Z A natural antiviral and immunomodulatory compound with antiangiogenic properties Bueno, Carlos Alberto Lombardi, María Gabriela Alche, Laura Edith 1 cinnamoyl 3,11 dihydroxymeliacarpin angiogenesis inhibitor antivirus agent immunomodulating agent interleukin 6 lipopolysaccharide meliacine tumor necrosis factor alpha unclassified drug vasculotropin vasculotropin A animal cell animal experiment animal model antiangiogenic activity antiproliferative activity article cell function cell stimulation cell viability chemotaxis concentration response controlled study cytokine production female Herpes simplex virus 1 human human cell immunomodulation in vitro study in vivo study migration inhibition mouse nonhuman priority journal protein expression umbilical vein endothelial cell Angiogenesis Inhibitors Animals Antiviral Agents Cell Proliferation Chemistry, Pharmaceutical Chemotaxis Drug Design Female Gene Expression Regulation Herpesvirus 1, Human Humans Immunologic Factors Lipopolysaccharides Melia Mice Mice, Inbred BALB C Neoplasms Neovascularization, Pathologic Peptides Plant Extracts Plant Proteins Vascular Endothelial Growth Factor A Human herpesvirus 1 Melia azedarach Murinae Mus Meliacine (MA), an antiviral principle present in partially purified leaf extracts of Melia azedarach L., reduces viral load and abolishes the inflammatory reaction and neovascularization during the development of herpetic stromal keratitis in mice. 1-cinnamoyl-3,11-dihydroxymeliacarpin (CDM), obtained from MA, displays anti-herpetic and immunomodulatory activities in vitro. We investigated whether CDM interferes with the angiogenic process. CDM impeded VEGF transcription in LPS-stimulated and HSV-1-infected cells. It proved to have neither cytotoxic nor antiproliferative effect in HUVEC and to restrain HUVEC migration and formation of capillary-like tubes. Moreover, MA inhibits LMM3 tumor-induced neovascularization in vivo. We postulate that the antiangiogenic activity of CDM displayed in vitro as a consequence of their immunomodulatory properties is responsible for the antiangiogenic activity of MA in vivo, which would be associated with the lack of neovascularization in murine HSV-1-induced ocular disease. © 2012 Elsevier Inc. Fil:Bueno, C.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Lombardi, M.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Alché, L.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00262862_v84_n3_p235_Bueno http://hdl.handle.net/20.500.12110/paper_00262862_v84_n3_p235_Bueno
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	1 cinnamoyl 3,11 dihydroxymeliacarpin angiogenesis inhibitor antivirus agent immunomodulating agent interleukin 6 lipopolysaccharide meliacine tumor necrosis factor alpha unclassified drug vasculotropin vasculotropin A animal cell animal experiment animal model antiangiogenic activity antiproliferative activity article cell function cell stimulation cell viability chemotaxis concentration response controlled study cytokine production female Herpes simplex virus 1 human human cell immunomodulation in vitro study in vivo study migration inhibition mouse nonhuman priority journal protein expression umbilical vein endothelial cell Angiogenesis Inhibitors Animals Antiviral Agents Cell Proliferation Chemistry, Pharmaceutical Chemotaxis Drug Design Female Gene Expression Regulation Herpesvirus 1, Human Humans Immunologic Factors Lipopolysaccharides Melia Mice Mice, Inbred BALB C Neoplasms Neovascularization, Pathologic Peptides Plant Extracts Plant Proteins Vascular Endothelial Growth Factor A Human herpesvirus 1 Melia azedarach Murinae Mus
spellingShingle	1 cinnamoyl 3,11 dihydroxymeliacarpin angiogenesis inhibitor antivirus agent immunomodulating agent interleukin 6 lipopolysaccharide meliacine tumor necrosis factor alpha unclassified drug vasculotropin vasculotropin A animal cell animal experiment animal model antiangiogenic activity antiproliferative activity article cell function cell stimulation cell viability chemotaxis concentration response controlled study cytokine production female Herpes simplex virus 1 human human cell immunomodulation in vitro study in vivo study migration inhibition mouse nonhuman priority journal protein expression umbilical vein endothelial cell Angiogenesis Inhibitors Animals Antiviral Agents Cell Proliferation Chemistry, Pharmaceutical Chemotaxis Drug Design Female Gene Expression Regulation Herpesvirus 1, Human Humans Immunologic Factors Lipopolysaccharides Melia Mice Mice, Inbred BALB C Neoplasms Neovascularization, Pathologic Peptides Plant Extracts Plant Proteins Vascular Endothelial Growth Factor A Human herpesvirus 1 Melia azedarach Murinae Mus Bueno, Carlos Alberto Lombardi, María Gabriela Alche, Laura Edith A natural antiviral and immunomodulatory compound with antiangiogenic properties
topic_facet	1 cinnamoyl 3,11 dihydroxymeliacarpin angiogenesis inhibitor antivirus agent immunomodulating agent interleukin 6 lipopolysaccharide meliacine tumor necrosis factor alpha unclassified drug vasculotropin vasculotropin A animal cell animal experiment animal model antiangiogenic activity antiproliferative activity article cell function cell stimulation cell viability chemotaxis concentration response controlled study cytokine production female Herpes simplex virus 1 human human cell immunomodulation in vitro study in vivo study migration inhibition mouse nonhuman priority journal protein expression umbilical vein endothelial cell Angiogenesis Inhibitors Animals Antiviral Agents Cell Proliferation Chemistry, Pharmaceutical Chemotaxis Drug Design Female Gene Expression Regulation Herpesvirus 1, Human Humans Immunologic Factors Lipopolysaccharides Melia Mice Mice, Inbred BALB C Neoplasms Neovascularization, Pathologic Peptides Plant Extracts Plant Proteins Vascular Endothelial Growth Factor A Human herpesvirus 1 Melia azedarach Murinae Mus
description	Meliacine (MA), an antiviral principle present in partially purified leaf extracts of Melia azedarach L., reduces viral load and abolishes the inflammatory reaction and neovascularization during the development of herpetic stromal keratitis in mice. 1-cinnamoyl-3,11-dihydroxymeliacarpin (CDM), obtained from MA, displays anti-herpetic and immunomodulatory activities in vitro. We investigated whether CDM interferes with the angiogenic process. CDM impeded VEGF transcription in LPS-stimulated and HSV-1-infected cells. It proved to have neither cytotoxic nor antiproliferative effect in HUVEC and to restrain HUVEC migration and formation of capillary-like tubes. Moreover, MA inhibits LMM3 tumor-induced neovascularization in vivo. We postulate that the antiangiogenic activity of CDM displayed in vitro as a consequence of their immunomodulatory properties is responsible for the antiangiogenic activity of MA in vivo, which would be associated with the lack of neovascularization in murine HSV-1-induced ocular disease. © 2012 Elsevier Inc.
author	Bueno, Carlos Alberto Lombardi, María Gabriela Alche, Laura Edith
author_facet	Bueno, Carlos Alberto Lombardi, María Gabriela Alche, Laura Edith
author_sort	Bueno, Carlos Alberto
title	A natural antiviral and immunomodulatory compound with antiangiogenic properties
title_short	A natural antiviral and immunomodulatory compound with antiangiogenic properties
title_full	A natural antiviral and immunomodulatory compound with antiangiogenic properties
title_fullStr	A natural antiviral and immunomodulatory compound with antiangiogenic properties
title_full_unstemmed	A natural antiviral and immunomodulatory compound with antiangiogenic properties
title_sort	natural antiviral and immunomodulatory compound with antiangiogenic properties
publishDate	2012
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00262862_v84_n3_p235_Bueno http://hdl.handle.net/20.500.12110/paper_00262862_v84_n3_p235_Bueno
work_keys_str_mv	AT buenocarlosalberto anaturalantiviralandimmunomodulatorycompoundwithantiangiogenicproperties AT lombardimariagabriela anaturalantiviralandimmunomodulatorycompoundwithantiangiogenicproperties AT alchelauraedith anaturalantiviralandimmunomodulatorycompoundwithantiangiogenicproperties AT buenocarlosalberto naturalantiviralandimmunomodulatorycompoundwithantiangiogenicproperties AT lombardimariagabriela naturalantiviralandimmunomodulatorycompoundwithantiangiogenicproperties AT alchelauraedith naturalantiviralandimmunomodulatorycompoundwithantiangiogenicproperties
_version_	1768545316954439680

A natural antiviral and immunomodulatory compound with antiangiogenic properties

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