Trypanosoma cruzi: Transport of essential metabolites acquired from the host
Trypanosoma cruzi is the etiological agent of Chagas disease, a disease endemic not only in Argentina but also in all of Latinamerica. T. cruzi presents several metabolic characteristics which are completely absent in its insect vectors and in mammalian hosts. Some of these differences were acquired...
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2008
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00257680_v68_n5_p398_Pereira http://hdl.handle.net/20.500.12110/paper_00257680_v68_n5_p398_Pereira |
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paper:paper_00257680_v68_n5_p398_Pereira2023-06-08T14:53:38Z Trypanosoma cruzi: Transport of essential metabolites acquired from the host Aminoacids Chagas disease Permeases Polyamines Transporters Trypanosoma cruzi amino acid transporter polyamine article Chagas disease drug targeting host parasite interaction human metabolite nonhuman parasite transmission protein analysis protein targeting Trypanosoma Trypanosoma cruzi Amino Acids Animals Argentina Biological Transport Chagas Disease Host-Parasite Interactions Humans Polyamines Protozoan Proteins Trypanosoma cruzi Trypanosoma cruzi is the etiological agent of Chagas disease, a disease endemic not only in Argentina but also in all of Latinamerica. T. cruzi presents several metabolic characteristics which are completely absent in its insect vectors and in mammalian hosts. Some of these differences were acquired after millions of years of adaptation to parasitism, during which this protozoan replaced many biosynthetic routes for transport systems. In the present review, we describe the advances in the knowledge of T. cruzi transport processes and the molecules involved. In particular, we focus on aminoacid and polyamine transporters from the AAAP family (Amino Acid/Auxin Permeases), because they seem to be exclusive transporters from trypanosomatids. Taking into account that these permeases are completely absent in mammals, they could be considered as a potential target against Trypanosoma cruzi. 2008 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00257680_v68_n5_p398_Pereira http://hdl.handle.net/20.500.12110/paper_00257680_v68_n5_p398_Pereira |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Aminoacids Chagas disease Permeases Polyamines Transporters Trypanosoma cruzi amino acid transporter polyamine article Chagas disease drug targeting host parasite interaction human metabolite nonhuman parasite transmission protein analysis protein targeting Trypanosoma Trypanosoma cruzi Amino Acids Animals Argentina Biological Transport Chagas Disease Host-Parasite Interactions Humans Polyamines Protozoan Proteins Trypanosoma cruzi |
| spellingShingle |
Aminoacids Chagas disease Permeases Polyamines Transporters Trypanosoma cruzi amino acid transporter polyamine article Chagas disease drug targeting host parasite interaction human metabolite nonhuman parasite transmission protein analysis protein targeting Trypanosoma Trypanosoma cruzi Amino Acids Animals Argentina Biological Transport Chagas Disease Host-Parasite Interactions Humans Polyamines Protozoan Proteins Trypanosoma cruzi Trypanosoma cruzi: Transport of essential metabolites acquired from the host |
| topic_facet |
Aminoacids Chagas disease Permeases Polyamines Transporters Trypanosoma cruzi amino acid transporter polyamine article Chagas disease drug targeting host parasite interaction human metabolite nonhuman parasite transmission protein analysis protein targeting Trypanosoma Trypanosoma cruzi Amino Acids Animals Argentina Biological Transport Chagas Disease Host-Parasite Interactions Humans Polyamines Protozoan Proteins Trypanosoma cruzi |
| description |
Trypanosoma cruzi is the etiological agent of Chagas disease, a disease endemic not only in Argentina but also in all of Latinamerica. T. cruzi presents several metabolic characteristics which are completely absent in its insect vectors and in mammalian hosts. Some of these differences were acquired after millions of years of adaptation to parasitism, during which this protozoan replaced many biosynthetic routes for transport systems. In the present review, we describe the advances in the knowledge of T. cruzi transport processes and the molecules involved. In particular, we focus on aminoacid and polyamine transporters from the AAAP family (Amino Acid/Auxin Permeases), because they seem to be exclusive transporters from trypanosomatids. Taking into account that these permeases are completely absent in mammals, they could be considered as a potential target against Trypanosoma cruzi. |
| title |
Trypanosoma cruzi: Transport of essential metabolites acquired from the host |
| title_short |
Trypanosoma cruzi: Transport of essential metabolites acquired from the host |
| title_full |
Trypanosoma cruzi: Transport of essential metabolites acquired from the host |
| title_fullStr |
Trypanosoma cruzi: Transport of essential metabolites acquired from the host |
| title_full_unstemmed |
Trypanosoma cruzi: Transport of essential metabolites acquired from the host |
| title_sort |
trypanosoma cruzi: transport of essential metabolites acquired from the host |
| publishDate |
2008 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00257680_v68_n5_p398_Pereira http://hdl.handle.net/20.500.12110/paper_00257680_v68_n5_p398_Pereira |
| _version_ |
1768542069611036672 |