Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients

Medical and biochemical analysis were performed on 58 patients with chronic alcoholism. In accordance with medical characterisation, patients were divided in three groups: A (patients having only hepatopathy), B (patients with hepatopathy and neuropathy) and C (patients having only alcoholic neuropa...

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Guardado en:
Detalles Bibliográficos
Publicado: 1997
Materias:
porphobilinogen synthase
adult
aged
alcoholism
article
female
human
male
metabolism
middle aged
Adult
Aged
Alcoholism
Female
Humans
Male
Middle Aged
Porphobilinogen Synthase
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00257680_v57_n3_p275_Wider
http://hdl.handle.net/20.500.12110/paper_00257680_v57_n3_p275_Wider
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_00257680_v57_n3_p275_Wider
record_format dspace
spelling paper:paper_00257680_v57_n3_p275_Wider2023-06-08T14:53:28Z Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients porphobilinogen synthase adult aged alcoholism article female human male metabolism middle aged Adult Aged Alcoholism Female Humans Male Middle Aged Porphobilinogen Synthase Medical and biochemical analysis were performed on 58 patients with chronic alcoholism. In accordance with medical characterisation, patients were divided in three groups: A (patients having only hepatopathy), B (patients with hepatopathy and neuropathy) and C (patients having only alcoholic neuropathy). Simultaneously, several parameters related to heme biosynthesis were examined. Urinary delta-aminolevulic acid (ALA), porphobilinogen (PBG) and porphyrins and fecal porphyrins measurements did not show significant difference among all studied groups. The activities of ALA-dehydratase (ALA-D), uroporphyrinogen-I-synthase (URO-I-S) and uroporphyrinogen-III-synthase (URO-III-S) were monitored in peripheral erythrocytes. From the enzymes measured, only ALA-D levels in groups B and C were significantly depressed (p < 0.002) compared with normal subjects. The decrease in ALA-D correlated with the degree of neuropathy. 1997 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00257680_v57_n3_p275_Wider http://hdl.handle.net/20.500.12110/paper_00257680_v57_n3_p275_Wider
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic porphobilinogen synthase
adult
aged
alcoholism
article
female
human
male
metabolism
middle aged
Adult
Aged
Alcoholism
Female
Humans
Male
Middle Aged
Porphobilinogen Synthase
spellingShingle porphobilinogen synthase
adult
aged
alcoholism
article
female
human
male
metabolism
middle aged
Adult
Aged
Alcoholism
Female
Humans
Male
Middle Aged
Porphobilinogen Synthase
Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients
topic_facet porphobilinogen synthase
adult
aged
alcoholism
article
female
human
male
metabolism
middle aged
Adult
Aged
Alcoholism
Female
Humans
Male
Middle Aged
Porphobilinogen Synthase
description Medical and biochemical analysis were performed on 58 patients with chronic alcoholism. In accordance with medical characterisation, patients were divided in three groups: A (patients having only hepatopathy), B (patients with hepatopathy and neuropathy) and C (patients having only alcoholic neuropathy). Simultaneously, several parameters related to heme biosynthesis were examined. Urinary delta-aminolevulic acid (ALA), porphobilinogen (PBG) and porphyrins and fecal porphyrins measurements did not show significant difference among all studied groups. The activities of ALA-dehydratase (ALA-D), uroporphyrinogen-I-synthase (URO-I-S) and uroporphyrinogen-III-synthase (URO-III-S) were monitored in peripheral erythrocytes. From the enzymes measured, only ALA-D levels in groups B and C were significantly depressed (p < 0.002) compared with normal subjects. The decrease in ALA-D correlated with the degree of neuropathy.
title Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients
title_short Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients
title_full Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients
title_fullStr Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients
title_full_unstemmed Modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients
title_sort modification of the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients
publishDate 1997
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00257680_v57_n3_p275_Wider
http://hdl.handle.net/20.500.12110/paper_00257680_v57_n3_p275_Wider
_version_ 1768546289111269376

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