Prolactin-releasing effect of tryptolines in the developing and adult male and female rats
The developmental prolactin-releasing effect of Tryptoline (T), Methoxytryptoline (MT) and Hydroxytryptoline (OHT) was examined comparatively in male and female rats. A single injection of T 15 mg/Kg increased serum prolactin in both sexes; the increase was significant from day 20 onwards. OHT evoke...
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1990
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v47_n18_p1635_Rey http://hdl.handle.net/20.500.12110/paper_00243205_v47_n18_p1635_Rey |
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paper:paper_00243205_v47_n18_p1635_Rey2023-06-08T14:51:59Z Prolactin-releasing effect of tryptolines in the developing and adult male and female rats 5 hydroxytryptoline 5 methoxytryptoline prolactin tryptoline unclassified drug adolescent animal experiment animal tissue article controlled study drug effect female male nonhuman priority journal prolactin release rat Aging Animal Carbolines Castration Female Male Prolactin Rats Rats, Inbred Strains Sex Characteristics Sex Maturation Support, Non-U.S. Gov't Animalia The developmental prolactin-releasing effect of Tryptoline (T), Methoxytryptoline (MT) and Hydroxytryptoline (OHT) was examined comparatively in male and female rats. A single injection of T 15 mg/Kg increased serum prolactin in both sexes; the increase was significant from day 20 onwards. OHT evoked a sharp rise in 12 day-old rats and the releasing effect increased with age, both in males and females. No significant sex differences were observed in T or OHT treated rats. MT caused an increment in prolactin secretion in male rats and this action increased with age. The releasing effect of MT was not significant in females, even at 38 postnatal days. In adult animals, the tryptolines (15 mg/Kg) were able to increase serum prolactin in males and in females in diestrous; a dose of 5 mg/Kg of T was only effective in adult male rats. The prolactin-releasing effect was drastically reduced by orchidectomy and by ovariectomy. LH, FSH and TSH were not modified by any treatment. The present results show for the first time the ontogeny of the prolactin -releasing effect of tryptolines in male and female rats and that this effect depends on the presence of gonadal secretions in adults. © 1990. 1990 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v47_n18_p1635_Rey http://hdl.handle.net/20.500.12110/paper_00243205_v47_n18_p1635_Rey |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
5 hydroxytryptoline 5 methoxytryptoline prolactin tryptoline unclassified drug adolescent animal experiment animal tissue article controlled study drug effect female male nonhuman priority journal prolactin release rat Aging Animal Carbolines Castration Female Male Prolactin Rats Rats, Inbred Strains Sex Characteristics Sex Maturation Support, Non-U.S. Gov't Animalia |
| spellingShingle |
5 hydroxytryptoline 5 methoxytryptoline prolactin tryptoline unclassified drug adolescent animal experiment animal tissue article controlled study drug effect female male nonhuman priority journal prolactin release rat Aging Animal Carbolines Castration Female Male Prolactin Rats Rats, Inbred Strains Sex Characteristics Sex Maturation Support, Non-U.S. Gov't Animalia Prolactin-releasing effect of tryptolines in the developing and adult male and female rats |
| topic_facet |
5 hydroxytryptoline 5 methoxytryptoline prolactin tryptoline unclassified drug adolescent animal experiment animal tissue article controlled study drug effect female male nonhuman priority journal prolactin release rat Aging Animal Carbolines Castration Female Male Prolactin Rats Rats, Inbred Strains Sex Characteristics Sex Maturation Support, Non-U.S. Gov't Animalia |
| description |
The developmental prolactin-releasing effect of Tryptoline (T), Methoxytryptoline (MT) and Hydroxytryptoline (OHT) was examined comparatively in male and female rats. A single injection of T 15 mg/Kg increased serum prolactin in both sexes; the increase was significant from day 20 onwards. OHT evoked a sharp rise in 12 day-old rats and the releasing effect increased with age, both in males and females. No significant sex differences were observed in T or OHT treated rats. MT caused an increment in prolactin secretion in male rats and this action increased with age. The releasing effect of MT was not significant in females, even at 38 postnatal days. In adult animals, the tryptolines (15 mg/Kg) were able to increase serum prolactin in males and in females in diestrous; a dose of 5 mg/Kg of T was only effective in adult male rats. The prolactin-releasing effect was drastically reduced by orchidectomy and by ovariectomy. LH, FSH and TSH were not modified by any treatment. The present results show for the first time the ontogeny of the prolactin -releasing effect of tryptolines in male and female rats and that this effect depends on the presence of gonadal secretions in adults. © 1990. |
| title |
Prolactin-releasing effect of tryptolines in the developing and adult male and female rats |
| title_short |
Prolactin-releasing effect of tryptolines in the developing and adult male and female rats |
| title_full |
Prolactin-releasing effect of tryptolines in the developing and adult male and female rats |
| title_fullStr |
Prolactin-releasing effect of tryptolines in the developing and adult male and female rats |
| title_full_unstemmed |
Prolactin-releasing effect of tryptolines in the developing and adult male and female rats |
| title_sort |
prolactin-releasing effect of tryptolines in the developing and adult male and female rats |
| publishDate |
1990 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v47_n18_p1635_Rey http://hdl.handle.net/20.500.12110/paper_00243205_v47_n18_p1635_Rey |
| _version_ |
1768541833826140160 |