Effect of GABA and benzodiazepines on testicular androgen production
We have evaluated the effect of R05-4864, a selective probe to label peripheral type benzodiazepine receptor, on "in vitro" testicular androgen production. Decapsulated testes from adult rats showed a significant increase in the basal and hCG-stimulated testosterone secretion into the medi...
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1987
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v40_n8_p791_Ritta http://hdl.handle.net/20.500.12110/paper_00243205_v40_n8_p791_Ritta |
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paper:paper_00243205_v40_n8_p791_Ritta |
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paper:paper_00243205_v40_n8_p791_Ritta2023-06-08T14:51:59Z Effect of GABA and benzodiazepines on testicular androgen production 4 aminobutyric acid 4' chlorodiazepam androstanediol benzodiazepine chorionic gonadotropin muscimol h 3 testosterone unclassified drug age androgen metabolism animal cell animal experiment dose response drug accumulation drug analysis drug determination drug interaction drug mechanism drug monitoring drug response drug tissue level male genital system nonhuman pharmacokinetics physiology priority journal rat testis Age Factors Androgens Animal Benzodiazepinones Chorionic Gonadotropin gamma-Aminobutyric Acid Male Rats Receptors, GABA-A Sex Maturation Support, Non-U.S. Gov't Testis We have evaluated the effect of R05-4864, a selective probe to label peripheral type benzodiazepine receptor, on "in vitro" testicular androgen production. Decapsulated testes from adult rats showed a significant increase in the basal and hCG-stimulated testosterone secretion into the medium in response to 10-5M, 10-6M, and 10-7M Ro5-4864. In addition, we have studied the changes in testicular GABA content at three different ages and we found its highest concentration at 31 days of age. When we evaluated the effect of GABA on "in vitro" androgen production at different stages of gonadal maturation we observed that the highest concentration of GABA (10-6M) was able to modify the basal and hCG-stimulated androgen production from adult (60 days) and pubertal (45 days) testes. In addition, when prepubertal testes (31 days) were incubated under basal conditions, 10-6M GABA induced a significant increment of androstanediol production, while the stimulatory effect of hCG was reduced in the presence of the same GABA concentration. The present results suggest that GABA plays a physiological role in the regulation of rat testicular androgen production depending on the stage of sexual maturation. © 1987. 1987 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v40_n8_p791_Ritta http://hdl.handle.net/20.500.12110/paper_00243205_v40_n8_p791_Ritta |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
4 aminobutyric acid 4' chlorodiazepam androstanediol benzodiazepine chorionic gonadotropin muscimol h 3 testosterone unclassified drug age androgen metabolism animal cell animal experiment dose response drug accumulation drug analysis drug determination drug interaction drug mechanism drug monitoring drug response drug tissue level male genital system nonhuman pharmacokinetics physiology priority journal rat testis Age Factors Androgens Animal Benzodiazepinones Chorionic Gonadotropin gamma-Aminobutyric Acid Male Rats Receptors, GABA-A Sex Maturation Support, Non-U.S. Gov't Testis |
| spellingShingle |
4 aminobutyric acid 4' chlorodiazepam androstanediol benzodiazepine chorionic gonadotropin muscimol h 3 testosterone unclassified drug age androgen metabolism animal cell animal experiment dose response drug accumulation drug analysis drug determination drug interaction drug mechanism drug monitoring drug response drug tissue level male genital system nonhuman pharmacokinetics physiology priority journal rat testis Age Factors Androgens Animal Benzodiazepinones Chorionic Gonadotropin gamma-Aminobutyric Acid Male Rats Receptors, GABA-A Sex Maturation Support, Non-U.S. Gov't Testis Effect of GABA and benzodiazepines on testicular androgen production |
| topic_facet |
4 aminobutyric acid 4' chlorodiazepam androstanediol benzodiazepine chorionic gonadotropin muscimol h 3 testosterone unclassified drug age androgen metabolism animal cell animal experiment dose response drug accumulation drug analysis drug determination drug interaction drug mechanism drug monitoring drug response drug tissue level male genital system nonhuman pharmacokinetics physiology priority journal rat testis Age Factors Androgens Animal Benzodiazepinones Chorionic Gonadotropin gamma-Aminobutyric Acid Male Rats Receptors, GABA-A Sex Maturation Support, Non-U.S. Gov't Testis |
| description |
We have evaluated the effect of R05-4864, a selective probe to label peripheral type benzodiazepine receptor, on "in vitro" testicular androgen production. Decapsulated testes from adult rats showed a significant increase in the basal and hCG-stimulated testosterone secretion into the medium in response to 10-5M, 10-6M, and 10-7M Ro5-4864. In addition, we have studied the changes in testicular GABA content at three different ages and we found its highest concentration at 31 days of age. When we evaluated the effect of GABA on "in vitro" androgen production at different stages of gonadal maturation we observed that the highest concentration of GABA (10-6M) was able to modify the basal and hCG-stimulated androgen production from adult (60 days) and pubertal (45 days) testes. In addition, when prepubertal testes (31 days) were incubated under basal conditions, 10-6M GABA induced a significant increment of androstanediol production, while the stimulatory effect of hCG was reduced in the presence of the same GABA concentration. The present results suggest that GABA plays a physiological role in the regulation of rat testicular androgen production depending on the stage of sexual maturation. © 1987. |
| title |
Effect of GABA and benzodiazepines on testicular androgen production |
| title_short |
Effect of GABA and benzodiazepines on testicular androgen production |
| title_full |
Effect of GABA and benzodiazepines on testicular androgen production |
| title_fullStr |
Effect of GABA and benzodiazepines on testicular androgen production |
| title_full_unstemmed |
Effect of GABA and benzodiazepines on testicular androgen production |
| title_sort |
effect of gaba and benzodiazepines on testicular androgen production |
| publishDate |
1987 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00243205_v40_n8_p791_Ritta http://hdl.handle.net/20.500.12110/paper_00243205_v40_n8_p791_Ritta |
| _version_ |
1768544539203600384 |