An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all new world hemorrhagic fever arenaviruses

Five New World (NW) arenaviruses cause human hemorrhagic fevers. Four of these arenaviruses are known to enter cells by binding human transferrin receptor 1 (hTfR1). Here we show that the fifth arenavirus, Chapare virus, similarly uses hTfR1. We also identify an anti-hTfR1 antibody, ch128.1, which e...

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Autores principales:	Cordo, Sandra M., Martínez, María Guadalupe, Candurra, Nélida Alicia
Publicado:	2012
Materias:	CD71 antigen epitope monoclonal antibody ch128.1 unclassified drug virus glycoprotein animal cell Arenavirus article binding affinity binding site Chapare virus controlled study Guanarito virus human human cell IC 50 Junin virus Lassa virus machupo arenavirus nonhuman nucleotide sequence priority journal Sabia virus virus entry virus replication Amino Acid Sequence Animals Antibodies Antigens, CD Arenaviruses, New World Cell Line Down-Regulation Hemorrhagic Fevers, Viral Humans Molecular Sequence Data Protein Structure, Tertiary Receptors, Transferrin Receptors, Virus Sequence Alignment Virus Internalization New world arenaviruses
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0022538X_v86_n7_p4024_Helguera http://hdl.handle.net/20.500.12110/paper_0022538X_v86_n7_p4024_Helguera
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_0022538X_v86_n7_p4024_Helguera
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spelling	paper:paper_0022538X_v86_n7_p4024_Helguera2023-06-08T14:51:26Z An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all new world hemorrhagic fever arenaviruses Cordo, Sandra M. Martínez, María Guadalupe Candurra, Nélida Alicia CD71 antigen epitope monoclonal antibody ch128.1 unclassified drug virus glycoprotein animal cell Arenavirus article binding affinity binding site Chapare virus controlled study Guanarito virus human human cell IC 50 Junin virus Lassa virus machupo arenavirus nonhuman nucleotide sequence priority journal Sabia virus virus entry virus replication Amino Acid Sequence Animals Antibodies Antigens, CD Arenaviruses, New World Cell Line Down-Regulation Hemorrhagic Fevers, Viral Humans Molecular Sequence Data Protein Structure, Tertiary Receptors, Transferrin Receptors, Virus Sequence Alignment Virus Internalization Arenavirus Junin virus New world arenaviruses Five New World (NW) arenaviruses cause human hemorrhagic fevers. Four of these arenaviruses are known to enter cells by binding human transferrin receptor 1 (hTfR1). Here we show that the fifth arenavirus, Chapare virus, similarly uses hTfR1. We also identify an anti-hTfR1 antibody, ch128.1, which efficiently inhibits entry mediated by the glycoproteins of all five viruses, as well as replication of infectious Junín virus. Our data indicate that allNWhemorrhagic fever arenaviruses utilize a common hTfR1 apical-domain epitope and suggest that therapeutic agents targeting this epitope, including ch128.1 itself, can be broadly effective in treating South American hemorrhagic fevers. © 2012, American Society for Microbiology. Fil:Cordo, S.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Martinez, M.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Candurra, N.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0022538X_v86_n7_p4024_Helguera http://hdl.handle.net/20.500.12110/paper_0022538X_v86_n7_p4024_Helguera
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	CD71 antigen epitope monoclonal antibody ch128.1 unclassified drug virus glycoprotein animal cell Arenavirus article binding affinity binding site Chapare virus controlled study Guanarito virus human human cell IC 50 Junin virus Lassa virus machupo arenavirus nonhuman nucleotide sequence priority journal Sabia virus virus entry virus replication Amino Acid Sequence Animals Antibodies Antigens, CD Arenaviruses, New World Cell Line Down-Regulation Hemorrhagic Fevers, Viral Humans Molecular Sequence Data Protein Structure, Tertiary Receptors, Transferrin Receptors, Virus Sequence Alignment Virus Internalization Arenavirus Junin virus New world arenaviruses
spellingShingle	CD71 antigen epitope monoclonal antibody ch128.1 unclassified drug virus glycoprotein animal cell Arenavirus article binding affinity binding site Chapare virus controlled study Guanarito virus human human cell IC 50 Junin virus Lassa virus machupo arenavirus nonhuman nucleotide sequence priority journal Sabia virus virus entry virus replication Amino Acid Sequence Animals Antibodies Antigens, CD Arenaviruses, New World Cell Line Down-Regulation Hemorrhagic Fevers, Viral Humans Molecular Sequence Data Protein Structure, Tertiary Receptors, Transferrin Receptors, Virus Sequence Alignment Virus Internalization Arenavirus Junin virus New world arenaviruses Cordo, Sandra M. Martínez, María Guadalupe Candurra, Nélida Alicia An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all new world hemorrhagic fever arenaviruses
topic_facet	CD71 antigen epitope monoclonal antibody ch128.1 unclassified drug virus glycoprotein animal cell Arenavirus article binding affinity binding site Chapare virus controlled study Guanarito virus human human cell IC 50 Junin virus Lassa virus machupo arenavirus nonhuman nucleotide sequence priority journal Sabia virus virus entry virus replication Amino Acid Sequence Animals Antibodies Antigens, CD Arenaviruses, New World Cell Line Down-Regulation Hemorrhagic Fevers, Viral Humans Molecular Sequence Data Protein Structure, Tertiary Receptors, Transferrin Receptors, Virus Sequence Alignment Virus Internalization Arenavirus Junin virus New world arenaviruses
description	Five New World (NW) arenaviruses cause human hemorrhagic fevers. Four of these arenaviruses are known to enter cells by binding human transferrin receptor 1 (hTfR1). Here we show that the fifth arenavirus, Chapare virus, similarly uses hTfR1. We also identify an anti-hTfR1 antibody, ch128.1, which efficiently inhibits entry mediated by the glycoproteins of all five viruses, as well as replication of infectious Junín virus. Our data indicate that allNWhemorrhagic fever arenaviruses utilize a common hTfR1 apical-domain epitope and suggest that therapeutic agents targeting this epitope, including ch128.1 itself, can be broadly effective in treating South American hemorrhagic fevers. © 2012, American Society for Microbiology.
author	Cordo, Sandra M. Martínez, María Guadalupe Candurra, Nélida Alicia
author_facet	Cordo, Sandra M. Martínez, María Guadalupe Candurra, Nélida Alicia
author_sort	Cordo, Sandra M.
title	An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all new world hemorrhagic fever arenaviruses
title_short	An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all new world hemorrhagic fever arenaviruses
title_full	An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all new world hemorrhagic fever arenaviruses
title_fullStr	An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all new world hemorrhagic fever arenaviruses
title_full_unstemmed	An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all new world hemorrhagic fever arenaviruses
title_sort	antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all new world hemorrhagic fever arenaviruses
publishDate	2012
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_0022538X_v86_n7_p4024_Helguera http://hdl.handle.net/20.500.12110/paper_0022538X_v86_n7_p4024_Helguera
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An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all new world hemorrhagic fever arenaviruses

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