Phase solubility studies and stability of cholesterol/β-cyclodextrin inclusion complexes
Background: Cyclodextrins (CDs) are able to enhance the solubility, stability and bioavailability of several bioactive hydrophobic compounds by complex formation. They can also be used for removal of undesired components (such as cholesterol, off-flavors or bitter components) present in foods. Altho...
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2011
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00225142_v91_n14_p2551_dosSantos http://hdl.handle.net/20.500.12110/paper_00225142_v91_n14_p2551_dosSantos |
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paper:paper_00225142_v91_n14_p2551_dosSantos2023-06-08T14:51:20Z Phase solubility studies and stability of cholesterol/β-cyclodextrin inclusion complexes Buera, María del Pilar Mazzobre, María Florencia Cholesterol Cyclodextrin Phase solubility Stability constants beta cyclodextrin derivative cholesterol coordination compound food additive ligand phytosterol water adsorption article chemical phenomena chemistry diet supplementation differential scanning calorimetry food handling freeze drying heat kinetics phase transition solubility Adsorption beta-Cyclodextrins Calorimetry, Differential Scanning Cholesterol Coordination Complexes Food Additives Food Handling Food, Fortified Freeze Drying Hot Temperature Hydrophobic and Hydrophilic Interactions Kinetics Ligands Phase Transition Phytosterols Solubility Water Background: Cyclodextrins (CDs) are able to enhance the solubility, stability and bioavailability of several bioactive hydrophobic compounds by complex formation. They can also be used for removal of undesired components (such as cholesterol, off-flavors or bitter components) present in foods. Although many patents account for the use of cyclodextrins for removal of cholesterol from dairy foods, there is no available information on the effect of water on encapsulation efficiency and on the stability of sterols in CDs. The aim of this work was to study the inclusion properties and the factors affecting the encapsulation and stability of cholesterol in β-cyclodextrin (BCD). The optimum encapsulation conditions (ligand-CD molar ratio, stirring time and temperature), and stability of the complexes as a function of storage time and water content were analyzed. Results: Phase solubility study pointed out the formation of 1:1 stoichiometric complexes between cholesterol and β-cyclodextrin, which was influenced by temperature variations. The process was shown to be exothermic and energetically favored. The presence of cholesterol greatly modified the BCD water sorption curves, being the amount of adsorbed water smaller in the combined systems. The principal 'driving force' for complex formation is the substitution of the high-enthalpy water molecules by an appropriate hydrophobic ligand. The freeze-dried complexes probed to be stable at different storage conditions. Conclusion: The phase solubility and stability data obtained could be essential for selecting the most suitable conditions when CDs are employed either for removing cholesterol or to incorporate functional ingredients (i.e. sitosterol) in the development of innovative food products. © 2011 Society of Chemical Industry. Fil:Buera, M.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Mazzobre, M.F. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2011 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00225142_v91_n14_p2551_dosSantos http://hdl.handle.net/20.500.12110/paper_00225142_v91_n14_p2551_dosSantos |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
Cholesterol Cyclodextrin Phase solubility Stability constants beta cyclodextrin derivative cholesterol coordination compound food additive ligand phytosterol water adsorption article chemical phenomena chemistry diet supplementation differential scanning calorimetry food handling freeze drying heat kinetics phase transition solubility Adsorption beta-Cyclodextrins Calorimetry, Differential Scanning Cholesterol Coordination Complexes Food Additives Food Handling Food, Fortified Freeze Drying Hot Temperature Hydrophobic and Hydrophilic Interactions Kinetics Ligands Phase Transition Phytosterols Solubility Water |
| spellingShingle |
Cholesterol Cyclodextrin Phase solubility Stability constants beta cyclodextrin derivative cholesterol coordination compound food additive ligand phytosterol water adsorption article chemical phenomena chemistry diet supplementation differential scanning calorimetry food handling freeze drying heat kinetics phase transition solubility Adsorption beta-Cyclodextrins Calorimetry, Differential Scanning Cholesterol Coordination Complexes Food Additives Food Handling Food, Fortified Freeze Drying Hot Temperature Hydrophobic and Hydrophilic Interactions Kinetics Ligands Phase Transition Phytosterols Solubility Water Buera, María del Pilar Mazzobre, María Florencia Phase solubility studies and stability of cholesterol/β-cyclodextrin inclusion complexes |
| topic_facet |
Cholesterol Cyclodextrin Phase solubility Stability constants beta cyclodextrin derivative cholesterol coordination compound food additive ligand phytosterol water adsorption article chemical phenomena chemistry diet supplementation differential scanning calorimetry food handling freeze drying heat kinetics phase transition solubility Adsorption beta-Cyclodextrins Calorimetry, Differential Scanning Cholesterol Coordination Complexes Food Additives Food Handling Food, Fortified Freeze Drying Hot Temperature Hydrophobic and Hydrophilic Interactions Kinetics Ligands Phase Transition Phytosterols Solubility Water |
| description |
Background: Cyclodextrins (CDs) are able to enhance the solubility, stability and bioavailability of several bioactive hydrophobic compounds by complex formation. They can also be used for removal of undesired components (such as cholesterol, off-flavors or bitter components) present in foods. Although many patents account for the use of cyclodextrins for removal of cholesterol from dairy foods, there is no available information on the effect of water on encapsulation efficiency and on the stability of sterols in CDs. The aim of this work was to study the inclusion properties and the factors affecting the encapsulation and stability of cholesterol in β-cyclodextrin (BCD). The optimum encapsulation conditions (ligand-CD molar ratio, stirring time and temperature), and stability of the complexes as a function of storage time and water content were analyzed. Results: Phase solubility study pointed out the formation of 1:1 stoichiometric complexes between cholesterol and β-cyclodextrin, which was influenced by temperature variations. The process was shown to be exothermic and energetically favored. The presence of cholesterol greatly modified the BCD water sorption curves, being the amount of adsorbed water smaller in the combined systems. The principal 'driving force' for complex formation is the substitution of the high-enthalpy water molecules by an appropriate hydrophobic ligand. The freeze-dried complexes probed to be stable at different storage conditions. Conclusion: The phase solubility and stability data obtained could be essential for selecting the most suitable conditions when CDs are employed either for removing cholesterol or to incorporate functional ingredients (i.e. sitosterol) in the development of innovative food products. © 2011 Society of Chemical Industry. |
| author |
Buera, María del Pilar Mazzobre, María Florencia |
| author_facet |
Buera, María del Pilar Mazzobre, María Florencia |
| author_sort |
Buera, María del Pilar |
| title |
Phase solubility studies and stability of cholesterol/β-cyclodextrin inclusion complexes |
| title_short |
Phase solubility studies and stability of cholesterol/β-cyclodextrin inclusion complexes |
| title_full |
Phase solubility studies and stability of cholesterol/β-cyclodextrin inclusion complexes |
| title_fullStr |
Phase solubility studies and stability of cholesterol/β-cyclodextrin inclusion complexes |
| title_full_unstemmed |
Phase solubility studies and stability of cholesterol/β-cyclodextrin inclusion complexes |
| title_sort |
phase solubility studies and stability of cholesterol/β-cyclodextrin inclusion complexes |
| publishDate |
2011 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00225142_v91_n14_p2551_dosSantos http://hdl.handle.net/20.500.12110/paper_00225142_v91_n14_p2551_dosSantos |
| work_keys_str_mv |
AT bueramariadelpilar phasesolubilitystudiesandstabilityofcholesterolbcyclodextrininclusioncomplexes AT mazzobremariaflorencia phasesolubilitystudiesandstabilityofcholesterolbcyclodextrininclusioncomplexes |
| _version_ |
1768543021782007808 |