Biosynthesis of bufadienolides in toads. III-Experiments with [2-14C]mevalonic acid, [20-14C]3β-hydroxy-5-pregnen-20-one and [20-14C]cholesterol
The biosynthesis of bufadienolides in Bufo paracnemis toads has been studied in different seasons of the year using [2-14C]mevalonic acid, [20-14C]pregnenolone, and [20-14C]cholesterol as precursors. The results showed that the doubly unsaturated δ-lactone ring of the bufadieno-lides is directly der...
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1972
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00224731_v3_n1_p11_Porto http://hdl.handle.net/20.500.12110/paper_00224731_v3_n1_p11_Porto |
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paper:paper_00224731_v3_n1_p11_Porto2023-06-08T14:51:04Z Biosynthesis of bufadienolides in toads. III-Experiments with [2-14C]mevalonic acid, [20-14C]3β-hydroxy-5-pregnen-20-one and [20-14C]cholesterol Porto, Ana María Baralle, Francisco Ernesto Gros, Eduardo Gervasio bufadienolide derivative carbon cholesterol mevalonic acid pregnenolone venom animal article biosynthesis gallbladder metabolism season toad Animal Bufanolides Bufonidae Carbon Isotopes Cholesterol Gallbladder Mevalonic Acid Pregnenolone Seasons Venoms The biosynthesis of bufadienolides in Bufo paracnemis toads has been studied in different seasons of the year using [2-14C]mevalonic acid, [20-14C]pregnenolone, and [20-14C]cholesterol as precursors. The results showed that the doubly unsaturated δ-lactone ring of the bufadieno-lides is directly derived from the cholesterol side chain without the compound's prior conversion into pregnenolone. The probable sequence in which the different bufadienolides are formed is discussed. © 1972. Fil:Porto, A.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Baralle, F.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Gros, E.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1972 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00224731_v3_n1_p11_Porto http://hdl.handle.net/20.500.12110/paper_00224731_v3_n1_p11_Porto |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
bufadienolide derivative carbon cholesterol mevalonic acid pregnenolone venom animal article biosynthesis gallbladder metabolism season toad Animal Bufanolides Bufonidae Carbon Isotopes Cholesterol Gallbladder Mevalonic Acid Pregnenolone Seasons Venoms |
| spellingShingle |
bufadienolide derivative carbon cholesterol mevalonic acid pregnenolone venom animal article biosynthesis gallbladder metabolism season toad Animal Bufanolides Bufonidae Carbon Isotopes Cholesterol Gallbladder Mevalonic Acid Pregnenolone Seasons Venoms Porto, Ana María Baralle, Francisco Ernesto Gros, Eduardo Gervasio Biosynthesis of bufadienolides in toads. III-Experiments with [2-14C]mevalonic acid, [20-14C]3β-hydroxy-5-pregnen-20-one and [20-14C]cholesterol |
| topic_facet |
bufadienolide derivative carbon cholesterol mevalonic acid pregnenolone venom animal article biosynthesis gallbladder metabolism season toad Animal Bufanolides Bufonidae Carbon Isotopes Cholesterol Gallbladder Mevalonic Acid Pregnenolone Seasons Venoms |
| description |
The biosynthesis of bufadienolides in Bufo paracnemis toads has been studied in different seasons of the year using [2-14C]mevalonic acid, [20-14C]pregnenolone, and [20-14C]cholesterol as precursors. The results showed that the doubly unsaturated δ-lactone ring of the bufadieno-lides is directly derived from the cholesterol side chain without the compound's prior conversion into pregnenolone. The probable sequence in which the different bufadienolides are formed is discussed. © 1972. |
| author |
Porto, Ana María Baralle, Francisco Ernesto Gros, Eduardo Gervasio |
| author_facet |
Porto, Ana María Baralle, Francisco Ernesto Gros, Eduardo Gervasio |
| author_sort |
Porto, Ana María |
| title |
Biosynthesis of bufadienolides in toads. III-Experiments with [2-14C]mevalonic acid, [20-14C]3β-hydroxy-5-pregnen-20-one and [20-14C]cholesterol |
| title_short |
Biosynthesis of bufadienolides in toads. III-Experiments with [2-14C]mevalonic acid, [20-14C]3β-hydroxy-5-pregnen-20-one and [20-14C]cholesterol |
| title_full |
Biosynthesis of bufadienolides in toads. III-Experiments with [2-14C]mevalonic acid, [20-14C]3β-hydroxy-5-pregnen-20-one and [20-14C]cholesterol |
| title_fullStr |
Biosynthesis of bufadienolides in toads. III-Experiments with [2-14C]mevalonic acid, [20-14C]3β-hydroxy-5-pregnen-20-one and [20-14C]cholesterol |
| title_full_unstemmed |
Biosynthesis of bufadienolides in toads. III-Experiments with [2-14C]mevalonic acid, [20-14C]3β-hydroxy-5-pregnen-20-one and [20-14C]cholesterol |
| title_sort |
biosynthesis of bufadienolides in toads. iii-experiments with [2-14c]mevalonic acid, [20-14c]3β-hydroxy-5-pregnen-20-one and [20-14c]cholesterol |
| publishDate |
1972 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00224731_v3_n1_p11_Porto http://hdl.handle.net/20.500.12110/paper_00224731_v3_n1_p11_Porto |
| work_keys_str_mv |
AT portoanamaria biosynthesisofbufadienolidesintoadsiiiexperimentswith214cmevalonicacid2014c3bhydroxy5pregnen20oneand2014ccholesterol AT barallefranciscoernesto biosynthesisofbufadienolidesintoadsiiiexperimentswith214cmevalonicacid2014c3bhydroxy5pregnen20oneand2014ccholesterol AT groseduardogervasio biosynthesisofbufadienolidesintoadsiiiexperimentswith214cmevalonicacid2014c3bhydroxy5pregnen20oneand2014ccholesterol |
| _version_ |
1768543690783981568 |