Effects of ACTH on the last step of aldosterone biosynthesis

The production of tritiated aldosterone and tritiated SM (a saponifiable 18-hydroxycorticosterone derivative) by rat adrenals were studied at various incubation times in absence or presence of two concentrations of ACTH. Tritiated 18-hydroxycorticosterone or 18-deoxyaldosterone served as precursors....

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Autores principales:	Cozza, Eduardo Néstor, Ceballos, Nora Raquel
Publicado:	1989
Materias:	18 hydroxycorticosterone aldosterone corticotropin radioisotope adrenal gland animal cell article nonhuman priority journal rat Adrenal Glands Aldosterone Animal Corticotropin Male Mitochondria Rats Support, Non-U.S. Gov't Animalia
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00224731_v33_n6_p1253_Cozza http://hdl.handle.net/20.500.12110/paper_00224731_v33_n6_p1253_Cozza
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00224731_v33_n6_p1253_Cozza
record_format	dspace
spelling	paper:paper_00224731_v33_n6_p1253_Cozza2023-06-08T14:51:04Z Effects of ACTH on the last step of aldosterone biosynthesis Cozza, Eduardo Néstor Ceballos, Nora Raquel 18 hydroxycorticosterone aldosterone corticotropin radioisotope adrenal gland animal cell article nonhuman priority journal rat Adrenal Glands Aldosterone Animal Corticotropin Male Mitochondria Rats Support, Non-U.S. Gov't Animalia The production of tritiated aldosterone and tritiated SM (a saponifiable 18-hydroxycorticosterone derivative) by rat adrenals were studied at various incubation times in absence or presence of two concentrations of ACTH. Tritiated 18-hydroxycorticosterone or 18-deoxyaldosterone served as precursors. The lower ACTH concentration (150 pM) increased the production of tritiated aldosterone. Whereas, the higher ACTH concentration (1.5 μM) stimulated tritiated aldosterone production at shorter incubation time (30 min), while after 60 min it inhibited. This time dependency would reflect variations in the levels of endogenous steroids. On the other hand, the effects of ACTH on tritiated SM production were opposite to those on tritiated aldosterone. In effect, while 150 pM ACTH inhibited SM production, 1.5 μM ACTH stimulated it. These results suggest that ACTH promotes opposite effects on the productions of aldosterone and SM and therefore both productions would be coordinated under the regulation of ACTH. © 1989. Fil:Cozza, E.N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Ceballos, N.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1989 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00224731_v33_n6_p1253_Cozza http://hdl.handle.net/20.500.12110/paper_00224731_v33_n6_p1253_Cozza
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	18 hydroxycorticosterone aldosterone corticotropin radioisotope adrenal gland animal cell article nonhuman priority journal rat Adrenal Glands Aldosterone Animal Corticotropin Male Mitochondria Rats Support, Non-U.S. Gov't Animalia
spellingShingle	18 hydroxycorticosterone aldosterone corticotropin radioisotope adrenal gland animal cell article nonhuman priority journal rat Adrenal Glands Aldosterone Animal Corticotropin Male Mitochondria Rats Support, Non-U.S. Gov't Animalia Cozza, Eduardo Néstor Ceballos, Nora Raquel Effects of ACTH on the last step of aldosterone biosynthesis
topic_facet	18 hydroxycorticosterone aldosterone corticotropin radioisotope adrenal gland animal cell article nonhuman priority journal rat Adrenal Glands Aldosterone Animal Corticotropin Male Mitochondria Rats Support, Non-U.S. Gov't Animalia
description	The production of tritiated aldosterone and tritiated SM (a saponifiable 18-hydroxycorticosterone derivative) by rat adrenals were studied at various incubation times in absence or presence of two concentrations of ACTH. Tritiated 18-hydroxycorticosterone or 18-deoxyaldosterone served as precursors. The lower ACTH concentration (150 pM) increased the production of tritiated aldosterone. Whereas, the higher ACTH concentration (1.5 μM) stimulated tritiated aldosterone production at shorter incubation time (30 min), while after 60 min it inhibited. This time dependency would reflect variations in the levels of endogenous steroids. On the other hand, the effects of ACTH on tritiated SM production were opposite to those on tritiated aldosterone. In effect, while 150 pM ACTH inhibited SM production, 1.5 μM ACTH stimulated it. These results suggest that ACTH promotes opposite effects on the productions of aldosterone and SM and therefore both productions would be coordinated under the regulation of ACTH. © 1989.
author	Cozza, Eduardo Néstor Ceballos, Nora Raquel
author_facet	Cozza, Eduardo Néstor Ceballos, Nora Raquel
author_sort	Cozza, Eduardo Néstor
title	Effects of ACTH on the last step of aldosterone biosynthesis
title_short	Effects of ACTH on the last step of aldosterone biosynthesis
title_full	Effects of ACTH on the last step of aldosterone biosynthesis
title_fullStr	Effects of ACTH on the last step of aldosterone biosynthesis
title_full_unstemmed	Effects of ACTH on the last step of aldosterone biosynthesis
title_sort	effects of acth on the last step of aldosterone biosynthesis
publishDate	1989
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00224731_v33_n6_p1253_Cozza http://hdl.handle.net/20.500.12110/paper_00224731_v33_n6_p1253_Cozza
work_keys_str_mv	AT cozzaeduardonestor effectsofacthonthelaststepofaldosteronebiosynthesis AT ceballosnoraraquel effectsofacthonthelaststepofaldosteronebiosynthesis
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Effects of ACTH on the last step of aldosterone biosynthesis

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