Versatile steroid molecules at the end of the aldosterone pathway

18-hydroxycorticosterone converts spontaneously and reversibly to a variety of less polar forms and derivatives, some of which are precursors to aldosterone. In particular, 21-hydroxy-11β,18-oxido-4-pregnene-3,20-dione (18-DAL) is hydroxylated to aldosterone with high yields in the presence of malat...

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Autores principales:	Aragones, Alcira, Ceballos, Nora Raquel, Burton, Gerardo, Cozza, Eduardo Néstor
Publicado:	1987
Materias:	aldosterone hormone precursor reduced nicotinamide adenine dinucleotide phosphate cattle metabolism mitochondrion nonhuman short survey 18-Hydroxycorticosterone Acid-Base Equilibrium Adrenal Cortex Aldosterone Animal Chemistry Homeostasis Hydrogen-Ion Concentration Protein Precursors Steroids
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00224731_v27_n4-6_p791_Lantos http://hdl.handle.net/20.500.12110/paper_00224731_v27_n4-6_p791_Lantos
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00224731_v27_n4-6_p791_Lantos
record_format	dspace
spelling	paper:paper_00224731_v27_n4-6_p791_Lantos2023-06-08T14:51:03Z Versatile steroid molecules at the end of the aldosterone pathway Aragones, Alcira Ceballos, Nora Raquel Burton, Gerardo Cozza, Eduardo Néstor aldosterone hormone precursor reduced nicotinamide adenine dinucleotide phosphate cattle metabolism mitochondrion nonhuman short survey 18-Hydroxycorticosterone Acid-Base Equilibrium Adrenal Cortex Aldosterone Animal Chemistry Homeostasis Hydrogen-Ion Concentration Protein Precursors Steroids 18-hydroxycorticosterone converts spontaneously and reversibly to a variety of less polar forms and derivatives, some of which are precursors to aldosterone. In particular, 21-hydroxy-11β,18-oxido-4-pregnene-3,20-dione (18-DAL) is hydroxylated to aldosterone with high yields in the presence of malate and NADP+ at pH 4.8.18-DAL also behaves as a metabolic intermediate between 18-OH-B and aldosterone accorcling to time-course and trapping experiments. Consequently, the final steps of the aldosterone pathway at pH 4.8 could be identified as 18-OH-B,18-DAL and aldosterone, in this sequence. The submitochondrial distribution of aldosterone biosynthesis is compatible with this postulate. The work also shows that some forms of 18-OH-B are promoters of hydrogen transport in renal tubuli and that this regulation may be independent of sodium reabsorption. These results suggest a regulatory model, new in steroid biology, accorcling to which steroid molecules bearing an oxidized angular C18-methyl may undergo structural changes between precursor ("P") and hormonal ("H") forms in response to homeostatic requirements. © 1987. Fil:Aragonés, A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Ceballos, N.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Burton, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Cozza, E.N. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1987 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00224731_v27_n4-6_p791_Lantos http://hdl.handle.net/20.500.12110/paper_00224731_v27_n4-6_p791_Lantos
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	aldosterone hormone precursor reduced nicotinamide adenine dinucleotide phosphate cattle metabolism mitochondrion nonhuman short survey 18-Hydroxycorticosterone Acid-Base Equilibrium Adrenal Cortex Aldosterone Animal Chemistry Homeostasis Hydrogen-Ion Concentration Protein Precursors Steroids
spellingShingle	aldosterone hormone precursor reduced nicotinamide adenine dinucleotide phosphate cattle metabolism mitochondrion nonhuman short survey 18-Hydroxycorticosterone Acid-Base Equilibrium Adrenal Cortex Aldosterone Animal Chemistry Homeostasis Hydrogen-Ion Concentration Protein Precursors Steroids Aragones, Alcira Ceballos, Nora Raquel Burton, Gerardo Cozza, Eduardo Néstor Versatile steroid molecules at the end of the aldosterone pathway
topic_facet	aldosterone hormone precursor reduced nicotinamide adenine dinucleotide phosphate cattle metabolism mitochondrion nonhuman short survey 18-Hydroxycorticosterone Acid-Base Equilibrium Adrenal Cortex Aldosterone Animal Chemistry Homeostasis Hydrogen-Ion Concentration Protein Precursors Steroids
description	18-hydroxycorticosterone converts spontaneously and reversibly to a variety of less polar forms and derivatives, some of which are precursors to aldosterone. In particular, 21-hydroxy-11β,18-oxido-4-pregnene-3,20-dione (18-DAL) is hydroxylated to aldosterone with high yields in the presence of malate and NADP+ at pH 4.8.18-DAL also behaves as a metabolic intermediate between 18-OH-B and aldosterone accorcling to time-course and trapping experiments. Consequently, the final steps of the aldosterone pathway at pH 4.8 could be identified as 18-OH-B,18-DAL and aldosterone, in this sequence. The submitochondrial distribution of aldosterone biosynthesis is compatible with this postulate. The work also shows that some forms of 18-OH-B are promoters of hydrogen transport in renal tubuli and that this regulation may be independent of sodium reabsorption. These results suggest a regulatory model, new in steroid biology, accorcling to which steroid molecules bearing an oxidized angular C18-methyl may undergo structural changes between precursor ("P") and hormonal ("H") forms in response to homeostatic requirements. © 1987.
author	Aragones, Alcira Ceballos, Nora Raquel Burton, Gerardo Cozza, Eduardo Néstor
author_facet	Aragones, Alcira Ceballos, Nora Raquel Burton, Gerardo Cozza, Eduardo Néstor
author_sort	Aragones, Alcira
title	Versatile steroid molecules at the end of the aldosterone pathway
title_short	Versatile steroid molecules at the end of the aldosterone pathway
title_full	Versatile steroid molecules at the end of the aldosterone pathway
title_fullStr	Versatile steroid molecules at the end of the aldosterone pathway
title_full_unstemmed	Versatile steroid molecules at the end of the aldosterone pathway
title_sort	versatile steroid molecules at the end of the aldosterone pathway
publishDate	1987
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00224731_v27_n4-6_p791_Lantos http://hdl.handle.net/20.500.12110/paper_00224731_v27_n4-6_p791_Lantos
work_keys_str_mv	AT aragonesalcira versatilesteroidmoleculesattheendofthealdosteronepathway AT ceballosnoraraquel versatilesteroidmoleculesattheendofthealdosteronepathway AT burtongerardo versatilesteroidmoleculesattheendofthealdosteronepathway AT cozzaeduardonestor versatilesteroidmoleculesattheendofthealdosteronepathway
_version_	1768541551983591424

Versatile steroid molecules at the end of the aldosterone pathway

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