Hypothalamic-hypophyseal-gonadal axis in the streptozotocin-induced diabetic male rat

In the present work it was observed that the diabetic state alters the hypophyseal response to castration, without the expected increase in the LH serum levels, as found in the control rats. On the other hand, the stimulation of the hypophysis with LHRH resulted in a lower response in the case of th...

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Autores principales:	Calvo, Juan Carlos, Barañao, José Lino S., Tesone, Marta, Charreau, Eduardo Hernán
Publicado:	1984
Materias:	gonadorelin isophane insulin luteinizing hormone radioisotope streptozocin 5alpha androstane 3alpha,17beta diol c 14 androstanolone c 14 animal experiment animal model diabetes mellitus drug efficacy endocrine system hypothalamus hypophysis gonad system nonhuman rat testosterone c 14 testosterone h 3 Animal Castration Diabetes Mellitus, Experimental Gonadorelin Hypothalamo-Hypophyseal System Luteinizing Hormone Male Organ Weight Rats Rats, Inbred Strains Receptors, Androgen Support, Non-U.S. Gov't Testis Testosterone Testosterone 5-alpha-Reductase
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00224731_v20_n3_p769_Calvo http://hdl.handle.net/20.500.12110/paper_00224731_v20_n3_p769_Calvo
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00224731_v20_n3_p769_Calvo
record_format	dspace
spelling	paper:paper_00224731_v20_n3_p769_Calvo2023-06-08T14:51:00Z Hypothalamic-hypophyseal-gonadal axis in the streptozotocin-induced diabetic male rat Calvo, Juan Carlos Barañao, José Lino S. Tesone, Marta Charreau, Eduardo Hernán gonadorelin isophane insulin luteinizing hormone radioisotope streptozocin 5alpha androstane 3alpha,17beta diol c 14 androstanolone c 14 animal experiment animal model diabetes mellitus drug efficacy endocrine system hypothalamus hypophysis gonad system nonhuman rat testosterone c 14 testosterone h 3 Animal Castration Diabetes Mellitus, Experimental Gonadorelin Hypothalamo-Hypophyseal System Luteinizing Hormone Male Organ Weight Rats Rats, Inbred Strains Receptors, Androgen Support, Non-U.S. Gov't Testis Testosterone Testosterone 5-alpha-Reductase In the present work it was observed that the diabetic state alters the hypophyseal response to castration, without the expected increase in the LH serum levels, as found in the control rats. On the other hand, the stimulation of the hypophysis with LHRH resulted in a lower response in the case of the diabetic animal. The results presented herein are in good agreement with the finding of a reduction in the number of androgen binding sites and also with a diminished activity of the 5α-reductase in the hypophysis from diabetic animals. The present results indicate an alteration in the hypophyseal gonadotropin production as well as in the overall process of hypophyseal response in experimental diabetes. © 1984. Fil:Calvo, J.C. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Barañao, S. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Tesone, M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Charreau, E.H. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1984 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00224731_v20_n3_p769_Calvo http://hdl.handle.net/20.500.12110/paper_00224731_v20_n3_p769_Calvo
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	gonadorelin isophane insulin luteinizing hormone radioisotope streptozocin 5alpha androstane 3alpha,17beta diol c 14 androstanolone c 14 animal experiment animal model diabetes mellitus drug efficacy endocrine system hypothalamus hypophysis gonad system nonhuman rat testosterone c 14 testosterone h 3 Animal Castration Diabetes Mellitus, Experimental Gonadorelin Hypothalamo-Hypophyseal System Luteinizing Hormone Male Organ Weight Rats Rats, Inbred Strains Receptors, Androgen Support, Non-U.S. Gov't Testis Testosterone Testosterone 5-alpha-Reductase
spellingShingle	gonadorelin isophane insulin luteinizing hormone radioisotope streptozocin 5alpha androstane 3alpha,17beta diol c 14 androstanolone c 14 animal experiment animal model diabetes mellitus drug efficacy endocrine system hypothalamus hypophysis gonad system nonhuman rat testosterone c 14 testosterone h 3 Animal Castration Diabetes Mellitus, Experimental Gonadorelin Hypothalamo-Hypophyseal System Luteinizing Hormone Male Organ Weight Rats Rats, Inbred Strains Receptors, Androgen Support, Non-U.S. Gov't Testis Testosterone Testosterone 5-alpha-Reductase Calvo, Juan Carlos Barañao, José Lino S. Tesone, Marta Charreau, Eduardo Hernán Hypothalamic-hypophyseal-gonadal axis in the streptozotocin-induced diabetic male rat
topic_facet	gonadorelin isophane insulin luteinizing hormone radioisotope streptozocin 5alpha androstane 3alpha,17beta diol c 14 androstanolone c 14 animal experiment animal model diabetes mellitus drug efficacy endocrine system hypothalamus hypophysis gonad system nonhuman rat testosterone c 14 testosterone h 3 Animal Castration Diabetes Mellitus, Experimental Gonadorelin Hypothalamo-Hypophyseal System Luteinizing Hormone Male Organ Weight Rats Rats, Inbred Strains Receptors, Androgen Support, Non-U.S. Gov't Testis Testosterone Testosterone 5-alpha-Reductase
description	In the present work it was observed that the diabetic state alters the hypophyseal response to castration, without the expected increase in the LH serum levels, as found in the control rats. On the other hand, the stimulation of the hypophysis with LHRH resulted in a lower response in the case of the diabetic animal. The results presented herein are in good agreement with the finding of a reduction in the number of androgen binding sites and also with a diminished activity of the 5α-reductase in the hypophysis from diabetic animals. The present results indicate an alteration in the hypophyseal gonadotropin production as well as in the overall process of hypophyseal response in experimental diabetes. © 1984.
author	Calvo, Juan Carlos Barañao, José Lino S. Tesone, Marta Charreau, Eduardo Hernán
author_facet	Calvo, Juan Carlos Barañao, José Lino S. Tesone, Marta Charreau, Eduardo Hernán
author_sort	Calvo, Juan Carlos
title	Hypothalamic-hypophyseal-gonadal axis in the streptozotocin-induced diabetic male rat
title_short	Hypothalamic-hypophyseal-gonadal axis in the streptozotocin-induced diabetic male rat
title_full	Hypothalamic-hypophyseal-gonadal axis in the streptozotocin-induced diabetic male rat
title_fullStr	Hypothalamic-hypophyseal-gonadal axis in the streptozotocin-induced diabetic male rat
title_full_unstemmed	Hypothalamic-hypophyseal-gonadal axis in the streptozotocin-induced diabetic male rat
title_sort	hypothalamic-hypophyseal-gonadal axis in the streptozotocin-induced diabetic male rat
publishDate	1984
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00224731_v20_n3_p769_Calvo http://hdl.handle.net/20.500.12110/paper_00224731_v20_n3_p769_Calvo
work_keys_str_mv	AT calvojuancarlos hypothalamichypophysealgonadalaxisinthestreptozotocininduceddiabeticmalerat AT baranaojoselinos hypothalamichypophysealgonadalaxisinthestreptozotocininduceddiabeticmalerat AT tesonemarta hypothalamichypophysealgonadalaxisinthestreptozotocininduceddiabeticmalerat AT charreaueduardohernan hypothalamichypophysealgonadalaxisinthestreptozotocininduceddiabeticmalerat
_version_	1768542161761992704

Hypothalamic-hypophyseal-gonadal axis in the streptozotocin-induced diabetic male rat

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