Pattern of brain activation during social cognitive tasks is related to social competence in siblings discordant for schizophrenia
Measures of social competence are closely related to actual community functioning in patients with schizophrenia. However, the neurobiological mechanisms underlying competence in schizophrenia are not fully understood. We hypothesized that social deficits in schizophrenia are explained, at least in...
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2014
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| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223956_v56_n1_p120_Villarreal http://hdl.handle.net/20.500.12110/paper_00223956_v56_n1_p120_Villarreal |
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paper:paper_00223956_v56_n1_p120_Villarreal2023-06-08T14:50:32Z Pattern of brain activation during social cognitive tasks is related to social competence in siblings discordant for schizophrenia FMRI Hemispheric dominance Lateralization Schizophrenia Siblings Social skills adaptive behavior adult article case control study comparative study controlled study female functional magnetic resonance imaging heritability human male named inventories, questionnaires and rating scales observational study priority journal randomized controlled trial right hemisphere schizophrenia sibling social cognition social competence Social Skills Performance Assessment test of adaptive behavior in schizophrenia brain brain mapping cognition hemispheric dominance neuropsychological test nuclear magnetic resonance imaging pathophysiology physiology psychology schizophrenia social adaptation social behavior theory of mind Adult Brain Brain Mapping Case-Control Studies Cognition Female Functional Laterality Humans Magnetic Resonance Imaging Male Neuropsychological Tests Schizophrenia Schizophrenic Psychology Siblings Social Behavior Social Skills Theory of Mind Measures of social competence are closely related to actual community functioning in patients with schizophrenia. However, the neurobiological mechanisms underlying competence in schizophrenia are not fully understood. We hypothesized that social deficits in schizophrenia are explained, at least in part, by abnormally lateralized patterns of brain activation in response to tasks engaging social cognition, as compared to healthy individuals. We predicted such patterns would be partly heritable, and therefore affected in patients' nonpsychotic siblings as well. We used a functional magnetic resonance image paradigm to characterize brain activation induced by theory of mind tasks, and two tests of social competence, the Test of Adaptive Behavior in Schizophrenia (TABS), and the Social Skills Performance Assessment (SSPA) in siblings discordant for schizophrenia and comparable healthy controls (n=14 per group). Healthy individuals showed the strongest correlation between social competence and activation of right hemisphere structures involved in social cognitive processing, whereas in patients, the correlation pattern was lateralized to left hemisphere areas. Unaffected siblings of patients exhibited a pattern intermediate between the other groups. These results support the hypothesis that schizophrenia may be characterized by an abnormal functioning of nondominant hemisphere structures involved in the processing of socially salient information. © 2014 Elsevier Ltd. 2014 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223956_v56_n1_p120_Villarreal http://hdl.handle.net/20.500.12110/paper_00223956_v56_n1_p120_Villarreal |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
FMRI Hemispheric dominance Lateralization Schizophrenia Siblings Social skills adaptive behavior adult article case control study comparative study controlled study female functional magnetic resonance imaging heritability human male named inventories, questionnaires and rating scales observational study priority journal randomized controlled trial right hemisphere schizophrenia sibling social cognition social competence Social Skills Performance Assessment test of adaptive behavior in schizophrenia brain brain mapping cognition hemispheric dominance neuropsychological test nuclear magnetic resonance imaging pathophysiology physiology psychology schizophrenia social adaptation social behavior theory of mind Adult Brain Brain Mapping Case-Control Studies Cognition Female Functional Laterality Humans Magnetic Resonance Imaging Male Neuropsychological Tests Schizophrenia Schizophrenic Psychology Siblings Social Behavior Social Skills Theory of Mind |
| spellingShingle |
FMRI Hemispheric dominance Lateralization Schizophrenia Siblings Social skills adaptive behavior adult article case control study comparative study controlled study female functional magnetic resonance imaging heritability human male named inventories, questionnaires and rating scales observational study priority journal randomized controlled trial right hemisphere schizophrenia sibling social cognition social competence Social Skills Performance Assessment test of adaptive behavior in schizophrenia brain brain mapping cognition hemispheric dominance neuropsychological test nuclear magnetic resonance imaging pathophysiology physiology psychology schizophrenia social adaptation social behavior theory of mind Adult Brain Brain Mapping Case-Control Studies Cognition Female Functional Laterality Humans Magnetic Resonance Imaging Male Neuropsychological Tests Schizophrenia Schizophrenic Psychology Siblings Social Behavior Social Skills Theory of Mind Pattern of brain activation during social cognitive tasks is related to social competence in siblings discordant for schizophrenia |
| topic_facet |
FMRI Hemispheric dominance Lateralization Schizophrenia Siblings Social skills adaptive behavior adult article case control study comparative study controlled study female functional magnetic resonance imaging heritability human male named inventories, questionnaires and rating scales observational study priority journal randomized controlled trial right hemisphere schizophrenia sibling social cognition social competence Social Skills Performance Assessment test of adaptive behavior in schizophrenia brain brain mapping cognition hemispheric dominance neuropsychological test nuclear magnetic resonance imaging pathophysiology physiology psychology schizophrenia social adaptation social behavior theory of mind Adult Brain Brain Mapping Case-Control Studies Cognition Female Functional Laterality Humans Magnetic Resonance Imaging Male Neuropsychological Tests Schizophrenia Schizophrenic Psychology Siblings Social Behavior Social Skills Theory of Mind |
| description |
Measures of social competence are closely related to actual community functioning in patients with schizophrenia. However, the neurobiological mechanisms underlying competence in schizophrenia are not fully understood. We hypothesized that social deficits in schizophrenia are explained, at least in part, by abnormally lateralized patterns of brain activation in response to tasks engaging social cognition, as compared to healthy individuals. We predicted such patterns would be partly heritable, and therefore affected in patients' nonpsychotic siblings as well. We used a functional magnetic resonance image paradigm to characterize brain activation induced by theory of mind tasks, and two tests of social competence, the Test of Adaptive Behavior in Schizophrenia (TABS), and the Social Skills Performance Assessment (SSPA) in siblings discordant for schizophrenia and comparable healthy controls (n=14 per group). Healthy individuals showed the strongest correlation between social competence and activation of right hemisphere structures involved in social cognitive processing, whereas in patients, the correlation pattern was lateralized to left hemisphere areas. Unaffected siblings of patients exhibited a pattern intermediate between the other groups. These results support the hypothesis that schizophrenia may be characterized by an abnormal functioning of nondominant hemisphere structures involved in the processing of socially salient information. © 2014 Elsevier Ltd. |
| title |
Pattern of brain activation during social cognitive tasks is related to social competence in siblings discordant for schizophrenia |
| title_short |
Pattern of brain activation during social cognitive tasks is related to social competence in siblings discordant for schizophrenia |
| title_full |
Pattern of brain activation during social cognitive tasks is related to social competence in siblings discordant for schizophrenia |
| title_fullStr |
Pattern of brain activation during social cognitive tasks is related to social competence in siblings discordant for schizophrenia |
| title_full_unstemmed |
Pattern of brain activation during social cognitive tasks is related to social competence in siblings discordant for schizophrenia |
| title_sort |
pattern of brain activation during social cognitive tasks is related to social competence in siblings discordant for schizophrenia |
| publishDate |
2014 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223956_v56_n1_p120_Villarreal http://hdl.handle.net/20.500.12110/paper_00223956_v56_n1_p120_Villarreal |
| _version_ |
1768543407384297472 |