Factors underlying the variable inotropic effect of ouabain on isolated rat atria. Changes in contractile frequency and adrenergic mechanisms

The effects of concentrations of ouabain on the isometric developed tension (IDT) of isolated left auricles driven at 0·4, 0·8 and 3·3 Hz, were explored. With 0·4 or 0·8 Hz, increasing concentrations of ouabain (3·4 or 6·8 times 10−6; 1·0; 3·4 or 6·8 times 10−6M) elicited a decreasing enhancement of...

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Guardado en:
Detalles Bibliográficos
Publicado: 1979
Materias:
3',4' dihydroxy 2 methylpropiophenone
adrenergic receptor
cocaine
ouabain
reserpine
sotalol
tyramine
3',4' dihydroxy o methylpropiophenone
animal experiment
catecholamine depletion
drug response
drug screening
drug sensitivity
heart
heart atrium
heart atrium contraction
heart contraction
in vitro study
isometric tension
rat
Animal
Catecholamines
Cocaine
Drug Interactions
Heart Rate
In Vitro
Male
Myocardial Contraction
Ouabain
Rats
Reserpine
Sotalol
Sympathetic Nervous System
Tyramine
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223573_v31_n1_p545_GIMENO
http://hdl.handle.net/20.500.12110/paper_00223573_v31_n1_p545_GIMENO
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

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