In situ characterization of a rectifying electrical junction
Electrical synapses play significant roles in neural processing in invertebrate and vertebrate nervous systems. The view of electrical synapses as plain bidirectional intercellular channels represents a partial picture because rectifying electrical synapses expand the complexity in the communication...
Guardado en:
| Autores principales: | , |
|---|---|
| Publicado: |
2007
|
| Materias: | |
| Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223077_v97_n2_p1405_Rela http://hdl.handle.net/20.500.12110/paper_00223077_v97_n2_p1405_Rela |
| Aporte de: |
| id |
paper:paper_00223077_v97_n2_p1405_Rela |
|---|---|
| record_format |
dspace |
| spelling |
paper:paper_00223077_v97_n2_p1405_Rela2023-06-08T14:49:14Z In situ characterization of a rectifying electrical junction Rela, Lorena Szczupak, Lidia animal tissue article excitatory junction potential ganglion hyperpolarization motoneuron nerve cell nerve cell membrane potential nerve conduction nervous system neurotransmission nonhuman priority journal signal transduction synapse Animals Electric Stimulation Electrophysiology Fluorescent Dyes Hirudo medicinalis Membrane Potentials Microscopy, Fluorescence Motor Neurons Patch-Clamp Techniques Software Synapses Electrical synapses play significant roles in neural processing in invertebrate and vertebrate nervous systems. The view of electrical synapses as plain bidirectional intercellular channels represents a partial picture because rectifying electrical synapses expand the complexity in the communication capabilities of neurons. Rectification derives, mostly, from the sensitivity of electrical junctions to the transjunctional potential (Vj) across the coupled cells. We analyzed the characteristics of this sensitivity and their effect on neuronal signaling, studying rectifying junctions present in the leech nervous system. The NS neurons, a pair of premotor nonspiking neurons present in each midbody ganglion, are electrically coupled to virtually every excitatory motor neuron. Studied at rest, only hyperpolarizing signals can be transmitted from NS to the motoneurons, and only depolarizing signals are conducted in the opposite direction. Our results show that small changes in the NS membrane potential (Vm) exerted an effective control of the firing frequency of the CV motoneurons (excitor of circular muscles). This effect revealed the existence of a threshold Vj across which the electrical synapse shifts from a nonconducting to a conducting state. The junction can operate as a relatively symmetrical bidirectional bridge provided that the transmitted signals do not cross this threshold transjunctional potential. Copyright © 2007 The American Physiological Society. Fil:Rela, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Szczupak, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2007 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223077_v97_n2_p1405_Rela http://hdl.handle.net/20.500.12110/paper_00223077_v97_n2_p1405_Rela |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
animal tissue article excitatory junction potential ganglion hyperpolarization motoneuron nerve cell nerve cell membrane potential nerve conduction nervous system neurotransmission nonhuman priority journal signal transduction synapse Animals Electric Stimulation Electrophysiology Fluorescent Dyes Hirudo medicinalis Membrane Potentials Microscopy, Fluorescence Motor Neurons Patch-Clamp Techniques Software Synapses |
| spellingShingle |
animal tissue article excitatory junction potential ganglion hyperpolarization motoneuron nerve cell nerve cell membrane potential nerve conduction nervous system neurotransmission nonhuman priority journal signal transduction synapse Animals Electric Stimulation Electrophysiology Fluorescent Dyes Hirudo medicinalis Membrane Potentials Microscopy, Fluorescence Motor Neurons Patch-Clamp Techniques Software Synapses Rela, Lorena Szczupak, Lidia In situ characterization of a rectifying electrical junction |
| topic_facet |
animal tissue article excitatory junction potential ganglion hyperpolarization motoneuron nerve cell nerve cell membrane potential nerve conduction nervous system neurotransmission nonhuman priority journal signal transduction synapse Animals Electric Stimulation Electrophysiology Fluorescent Dyes Hirudo medicinalis Membrane Potentials Microscopy, Fluorescence Motor Neurons Patch-Clamp Techniques Software Synapses |
| description |
Electrical synapses play significant roles in neural processing in invertebrate and vertebrate nervous systems. The view of electrical synapses as plain bidirectional intercellular channels represents a partial picture because rectifying electrical synapses expand the complexity in the communication capabilities of neurons. Rectification derives, mostly, from the sensitivity of electrical junctions to the transjunctional potential (Vj) across the coupled cells. We analyzed the characteristics of this sensitivity and their effect on neuronal signaling, studying rectifying junctions present in the leech nervous system. The NS neurons, a pair of premotor nonspiking neurons present in each midbody ganglion, are electrically coupled to virtually every excitatory motor neuron. Studied at rest, only hyperpolarizing signals can be transmitted from NS to the motoneurons, and only depolarizing signals are conducted in the opposite direction. Our results show that small changes in the NS membrane potential (Vm) exerted an effective control of the firing frequency of the CV motoneurons (excitor of circular muscles). This effect revealed the existence of a threshold Vj across which the electrical synapse shifts from a nonconducting to a conducting state. The junction can operate as a relatively symmetrical bidirectional bridge provided that the transmitted signals do not cross this threshold transjunctional potential. Copyright © 2007 The American Physiological Society. |
| author |
Rela, Lorena Szczupak, Lidia |
| author_facet |
Rela, Lorena Szczupak, Lidia |
| author_sort |
Rela, Lorena |
| title |
In situ characterization of a rectifying electrical junction |
| title_short |
In situ characterization of a rectifying electrical junction |
| title_full |
In situ characterization of a rectifying electrical junction |
| title_fullStr |
In situ characterization of a rectifying electrical junction |
| title_full_unstemmed |
In situ characterization of a rectifying electrical junction |
| title_sort |
in situ characterization of a rectifying electrical junction |
| publishDate |
2007 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223077_v97_n2_p1405_Rela http://hdl.handle.net/20.500.12110/paper_00223077_v97_n2_p1405_Rela |
| work_keys_str_mv |
AT relalorena insitucharacterizationofarectifyingelectricaljunction AT szczupaklidia insitucharacterizationofarectifyingelectricaljunction |
| _version_ |
1768545818762018816 |