Selective serotonin reuptake inhibitors induce spontaneous interneuronal activity in the leech nervous system
Serotonin [5-hydroxytryptamine (5-HT)] is a conspicuous neuromodulator of sensory-motor networks that affects a variety of neurons at different levels of the network hierarchy. Because of its many possible targets, it has been difficult to obtain a comprehensive picture of how 5-HT achieves its fina...
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paper:paper_00223077_v93_n5_p2644_Calvino2023-06-08T14:49:14Z Selective serotonin reuptake inhibitors induce spontaneous interneuronal activity in the leech nervous system Calviño, María Ana Iscla, Irene Szczupak, Lidia citalopram clomipramine fluoxetine imipramine serotonin serotonin uptake inhibitor tricyclic antidepressant agent animal cell animal experiment article controlled study data analysis electrophysiology ganglion interneuron leech motor system nerve cell nervous system nonhuman priority journal sensory system synaptic potential Action Potentials Adrenergic Uptake Inhibitors Animals Citalopram Drug Interactions Electric Stimulation Fluoxetine Ganglia, Invertebrate Imipramine Interneurons Leeches Membrane Potentials Neural Networks (Computer) Paroxetine Serotonin Serotonin Uptake Inhibitors Synapses Serotonin [5-hydroxytryptamine (5-HT)] is a conspicuous neuromodulator of sensory-motor networks that affects a variety of neurons at different levels of the network hierarchy. Because of its many possible targets, it has been difficult to obtain a comprehensive picture of how 5-HT achieves its final modulatory output on any given network. Our hypothesis is that the profile of 5-HT actions is dictated by its pattern of release from endogenous sites. We tested this hypothesis in the leech nervous system by means of a selective serotonin reuptake blocker (SSRI), fluoxetine. Fluoxetine evoked barrages of synaptic potentials in identified sensory, motor, and interneurons. This effect was mimicked by the tricyclic antidepressants imipramine and clomipramine, and by the SSRI citalopram, with relative efficacies that matched their known relative selectivities for the 5-HT transporter. The synaptic responses evoked by fluoxetine in different neurons were temporally correlated, suggesting that they had a common origin. The profile of the synaptic responses matched that expected from the activation of the mechanosensory pressure cells, known to act by polysynaptic pathways. The results suggest that endogenous 5-HT acted on cord spanning interneurons. On the other hand, bath-applied 5-HT evoked an effect different from that of the SSRI. Taken together, the results evidenced that the pattern of action of the monoamine is dictated by the spatial distribution of the 5-HT release sites. Copyright © 2005 The American Physiological Society. Fil:Calviño, M.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Iscla, I.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Szczupak, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2005 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223077_v93_n5_p2644_Calvino http://hdl.handle.net/20.500.12110/paper_00223077_v93_n5_p2644_Calvino |
| institution |
Universidad de Buenos Aires |
| institution_str |
I-28 |
| repository_str |
R-134 |
| collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
| topic |
citalopram clomipramine fluoxetine imipramine serotonin serotonin uptake inhibitor tricyclic antidepressant agent animal cell animal experiment article controlled study data analysis electrophysiology ganglion interneuron leech motor system nerve cell nervous system nonhuman priority journal sensory system synaptic potential Action Potentials Adrenergic Uptake Inhibitors Animals Citalopram Drug Interactions Electric Stimulation Fluoxetine Ganglia, Invertebrate Imipramine Interneurons Leeches Membrane Potentials Neural Networks (Computer) Paroxetine Serotonin Serotonin Uptake Inhibitors Synapses |
| spellingShingle |
citalopram clomipramine fluoxetine imipramine serotonin serotonin uptake inhibitor tricyclic antidepressant agent animal cell animal experiment article controlled study data analysis electrophysiology ganglion interneuron leech motor system nerve cell nervous system nonhuman priority journal sensory system synaptic potential Action Potentials Adrenergic Uptake Inhibitors Animals Citalopram Drug Interactions Electric Stimulation Fluoxetine Ganglia, Invertebrate Imipramine Interneurons Leeches Membrane Potentials Neural Networks (Computer) Paroxetine Serotonin Serotonin Uptake Inhibitors Synapses Calviño, María Ana Iscla, Irene Szczupak, Lidia Selective serotonin reuptake inhibitors induce spontaneous interneuronal activity in the leech nervous system |
| topic_facet |
citalopram clomipramine fluoxetine imipramine serotonin serotonin uptake inhibitor tricyclic antidepressant agent animal cell animal experiment article controlled study data analysis electrophysiology ganglion interneuron leech motor system nerve cell nervous system nonhuman priority journal sensory system synaptic potential Action Potentials Adrenergic Uptake Inhibitors Animals Citalopram Drug Interactions Electric Stimulation Fluoxetine Ganglia, Invertebrate Imipramine Interneurons Leeches Membrane Potentials Neural Networks (Computer) Paroxetine Serotonin Serotonin Uptake Inhibitors Synapses |
| description |
Serotonin [5-hydroxytryptamine (5-HT)] is a conspicuous neuromodulator of sensory-motor networks that affects a variety of neurons at different levels of the network hierarchy. Because of its many possible targets, it has been difficult to obtain a comprehensive picture of how 5-HT achieves its final modulatory output on any given network. Our hypothesis is that the profile of 5-HT actions is dictated by its pattern of release from endogenous sites. We tested this hypothesis in the leech nervous system by means of a selective serotonin reuptake blocker (SSRI), fluoxetine. Fluoxetine evoked barrages of synaptic potentials in identified sensory, motor, and interneurons. This effect was mimicked by the tricyclic antidepressants imipramine and clomipramine, and by the SSRI citalopram, with relative efficacies that matched their known relative selectivities for the 5-HT transporter. The synaptic responses evoked by fluoxetine in different neurons were temporally correlated, suggesting that they had a common origin. The profile of the synaptic responses matched that expected from the activation of the mechanosensory pressure cells, known to act by polysynaptic pathways. The results suggest that endogenous 5-HT acted on cord spanning interneurons. On the other hand, bath-applied 5-HT evoked an effect different from that of the SSRI. Taken together, the results evidenced that the pattern of action of the monoamine is dictated by the spatial distribution of the 5-HT release sites. Copyright © 2005 The American Physiological Society. |
| author |
Calviño, María Ana Iscla, Irene Szczupak, Lidia |
| author_facet |
Calviño, María Ana Iscla, Irene Szczupak, Lidia |
| author_sort |
Calviño, María Ana |
| title |
Selective serotonin reuptake inhibitors induce spontaneous interneuronal activity in the leech nervous system |
| title_short |
Selective serotonin reuptake inhibitors induce spontaneous interneuronal activity in the leech nervous system |
| title_full |
Selective serotonin reuptake inhibitors induce spontaneous interneuronal activity in the leech nervous system |
| title_fullStr |
Selective serotonin reuptake inhibitors induce spontaneous interneuronal activity in the leech nervous system |
| title_full_unstemmed |
Selective serotonin reuptake inhibitors induce spontaneous interneuronal activity in the leech nervous system |
| title_sort |
selective serotonin reuptake inhibitors induce spontaneous interneuronal activity in the leech nervous system |
| publishDate |
2005 |
| url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223077_v93_n5_p2644_Calvino http://hdl.handle.net/20.500.12110/paper_00223077_v93_n5_p2644_Calvino |
| work_keys_str_mv |
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| _version_ |
1768543643463843840 |