Modulation of Mechanosensory Responses by Motoneurons That Regulate Skin Surface Topology in the Leech

Central regulation of somatosensory signals has been extensively studied, but little is known about their regulation in the periphery. Given the widespread exposure of the skin sensory terminals to the environment, it is of interest to explore how somatosensory sensitivity is affected by changes in...

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Autores principales:	Rodríguez, Mariano Julián, Iscla, Irene, Szczupak, Lidia
Publicado:	2004
Materias:	animal experiment article depolarization ganglion leech mechanical stimulation motoneuron nerve cell excitability neuromodulation nonhuman priority journal sensory stimulation signal transduction skin surface somatosensory system T lymphocyte water flow Animals Biophysics Electric Stimulation Electrophysiology Feedback Leeches Mechanoreceptors Mechanotransduction, Cellular Membrane Potentials Microelectrodes Motor Neurons Physical Stimulation Skin Skin Physiology Videotape Recording
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223077_v91_n5_p2366_Rodriguez http://hdl.handle.net/20.500.12110/paper_00223077_v91_n5_p2366_Rodriguez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00223077_v91_n5_p2366_Rodriguez
record_format	dspace
spelling	paper:paper_00223077_v91_n5_p2366_Rodriguez2023-06-08T14:49:13Z Modulation of Mechanosensory Responses by Motoneurons That Regulate Skin Surface Topology in the Leech Rodríguez, Mariano Julián Iscla, Irene Szczupak, Lidia animal experiment article depolarization ganglion leech mechanical stimulation motoneuron nerve cell excitability neuromodulation nonhuman priority journal sensory stimulation signal transduction skin surface somatosensory system T lymphocyte water flow Animals Biophysics Electric Stimulation Electrophysiology Feedback Leeches Mechanoreceptors Mechanotransduction, Cellular Membrane Potentials Microelectrodes Motor Neurons Physical Stimulation Skin Skin Physiology Videotape Recording Central regulation of somatosensory signals has been extensively studied, but little is known about their regulation in the periphery. Given the widespread exposure of the skin sensory terminals to the environment, it is of interest to explore how somatosensory sensitivity is affected by changes in properties of the skin. In the leech, the annuli that subdivide the skin can be erected under the control of the annulus erector (AE) motoneurons. To analyze whether this surface change influences mechanosensory sensitivity, we studied the responses of low threshold mechanosensory T cells to mechanical stimulation of the skin as AE motoneurons were activated. In segments of the body wall connected to the corresponding ganglion and submerged in an aqueous environment, T cells responded to localized bubbling on the skin and to water flow parallel to its surface. Excitation of AE motoneurons diminished these responses in a way that depended on the motoneuron firing frequency. Video recordings established that the range of AE firing frequencies that produced effective annulus erection coincided with that influencing T cell responses. In isolated ganglia, AE firing had no effect on T cell excitability, suggesting that annulus erection diminished T cell responsiveness to mechanical input. Counteracting this effect, mechanosensory inputs inhibited AE motoneurons. However, because depolarization of AE cells caused a decrease in their input resistance, the more active the motoneuron, the less sensitive it became to inhibitory signals. Thus when brought to fire, AE motoneurons would stay "committed" to a high activity level, and this would limit sensory responsiveness to incoming mechanical signals. Fil:Rodriguez, M.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Iscla, I.R. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Szczupak, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2004 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223077_v91_n5_p2366_Rodriguez http://hdl.handle.net/20.500.12110/paper_00223077_v91_n5_p2366_Rodriguez
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	animal experiment article depolarization ganglion leech mechanical stimulation motoneuron nerve cell excitability neuromodulation nonhuman priority journal sensory stimulation signal transduction skin surface somatosensory system T lymphocyte water flow Animals Biophysics Electric Stimulation Electrophysiology Feedback Leeches Mechanoreceptors Mechanotransduction, Cellular Membrane Potentials Microelectrodes Motor Neurons Physical Stimulation Skin Skin Physiology Videotape Recording
spellingShingle	animal experiment article depolarization ganglion leech mechanical stimulation motoneuron nerve cell excitability neuromodulation nonhuman priority journal sensory stimulation signal transduction skin surface somatosensory system T lymphocyte water flow Animals Biophysics Electric Stimulation Electrophysiology Feedback Leeches Mechanoreceptors Mechanotransduction, Cellular Membrane Potentials Microelectrodes Motor Neurons Physical Stimulation Skin Skin Physiology Videotape Recording Rodríguez, Mariano Julián Iscla, Irene Szczupak, Lidia Modulation of Mechanosensory Responses by Motoneurons That Regulate Skin Surface Topology in the Leech
topic_facet	animal experiment article depolarization ganglion leech mechanical stimulation motoneuron nerve cell excitability neuromodulation nonhuman priority journal sensory stimulation signal transduction skin surface somatosensory system T lymphocyte water flow Animals Biophysics Electric Stimulation Electrophysiology Feedback Leeches Mechanoreceptors Mechanotransduction, Cellular Membrane Potentials Microelectrodes Motor Neurons Physical Stimulation Skin Skin Physiology Videotape Recording
description	Central regulation of somatosensory signals has been extensively studied, but little is known about their regulation in the periphery. Given the widespread exposure of the skin sensory terminals to the environment, it is of interest to explore how somatosensory sensitivity is affected by changes in properties of the skin. In the leech, the annuli that subdivide the skin can be erected under the control of the annulus erector (AE) motoneurons. To analyze whether this surface change influences mechanosensory sensitivity, we studied the responses of low threshold mechanosensory T cells to mechanical stimulation of the skin as AE motoneurons were activated. In segments of the body wall connected to the corresponding ganglion and submerged in an aqueous environment, T cells responded to localized bubbling on the skin and to water flow parallel to its surface. Excitation of AE motoneurons diminished these responses in a way that depended on the motoneuron firing frequency. Video recordings established that the range of AE firing frequencies that produced effective annulus erection coincided with that influencing T cell responses. In isolated ganglia, AE firing had no effect on T cell excitability, suggesting that annulus erection diminished T cell responsiveness to mechanical input. Counteracting this effect, mechanosensory inputs inhibited AE motoneurons. However, because depolarization of AE cells caused a decrease in their input resistance, the more active the motoneuron, the less sensitive it became to inhibitory signals. Thus when brought to fire, AE motoneurons would stay "committed" to a high activity level, and this would limit sensory responsiveness to incoming mechanical signals.
author	Rodríguez, Mariano Julián Iscla, Irene Szczupak, Lidia
author_facet	Rodríguez, Mariano Julián Iscla, Irene Szczupak, Lidia
author_sort	Rodríguez, Mariano Julián
title	Modulation of Mechanosensory Responses by Motoneurons That Regulate Skin Surface Topology in the Leech
title_short	Modulation of Mechanosensory Responses by Motoneurons That Regulate Skin Surface Topology in the Leech
title_full	Modulation of Mechanosensory Responses by Motoneurons That Regulate Skin Surface Topology in the Leech
title_fullStr	Modulation of Mechanosensory Responses by Motoneurons That Regulate Skin Surface Topology in the Leech
title_full_unstemmed	Modulation of Mechanosensory Responses by Motoneurons That Regulate Skin Surface Topology in the Leech
title_sort	modulation of mechanosensory responses by motoneurons that regulate skin surface topology in the leech
publishDate	2004
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223077_v91_n5_p2366_Rodriguez http://hdl.handle.net/20.500.12110/paper_00223077_v91_n5_p2366_Rodriguez
work_keys_str_mv	AT rodriguezmarianojulian modulationofmechanosensoryresponsesbymotoneuronsthatregulateskinsurfacetopologyintheleech AT isclairene modulationofmechanosensoryresponsesbymotoneuronsthatregulateskinsurfacetopologyintheleech AT szczupaklidia modulationofmechanosensoryresponsesbymotoneuronsthatregulateskinsurfacetopologyintheleech
_version_	1768544673289207808

Modulation of Mechanosensory Responses by Motoneurons That Regulate Skin Surface Topology in the Leech

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