Wide propagation of graded signals in nonspiking neurons

Signal processing in neuritic trees is ruled by the concerted action of passive and active membrane properties that, together, determine the degree of electrical compartmentalization of these trees. We analyzed how active properties modulate spatial propagation of graded signals in a pair of nonspik...

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Autores principales:	Yang, Sung Min, Vilarchao, María Eugenia, Rela, Lorena, Szczupak, Lidia
Publicado:	2013
Materias:	Calcium transients Low threshold spike Signal propagation fluorescent dye magnesium amplitude modulation article calcium conductance calcium transport controlled study depolarization evoked response ganglion leech membrane potential motoneuron nerve cell neurite nonhuman nonspiking neuron priority journal Action Potentials Animals Calcium Calcium Channels Ganglia, Invertebrate Leeches Mechanoreceptors Mechanotransduction, Cellular Motor Neurons Synaptic Potentials
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223077_v109_n3_p711_Yang http://hdl.handle.net/20.500.12110/paper_00223077_v109_n3_p711_Yang
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00223077_v109_n3_p711_Yang
record_format	dspace
spelling	paper:paper_00223077_v109_n3_p711_Yang2023-06-08T14:49:12Z Wide propagation of graded signals in nonspiking neurons Yang, Sung Min Vilarchao, María Eugenia Rela, Lorena Szczupak, Lidia Calcium transients Low threshold spike Signal propagation fluorescent dye magnesium amplitude modulation article calcium conductance calcium transport controlled study depolarization evoked response ganglion leech membrane potential motoneuron nerve cell neurite nonhuman nonspiking neuron priority journal Action Potentials Animals Calcium Calcium Channels Ganglia, Invertebrate Leeches Mechanoreceptors Mechanotransduction, Cellular Motor Neurons Synaptic Potentials Signal processing in neuritic trees is ruled by the concerted action of passive and active membrane properties that, together, determine the degree of electrical compartmentalization of these trees. We analyzed how active properties modulate spatial propagation of graded signals in a pair of nonspiking (NS) neurons of the leech. NS neurons present a very extensive neuritic tree that mediates the interaction with all the excitatory motoneurons in leech ganglia. NS cells express voltageactivated Ca 2+ conductances (VACCs) that, under certain experimental conditions, evoke low-threshold spikes. We studied the distribution of calcium transients in NS neurons loaded with fluorescent calcium probes in response to low-threshold spikes, electrical depolarizing pulses, and synaptic inputs. The three types of stimuli evoked calcium transients of similar characteristics in the four main branches of the neuron. The magnitude of the calcium transients evoked by electrical pulses was a graded function of the change in NS membrane potential and depended on the baseline potential level. The underlying VACCs were partially inactivated at rest and strongly inactivated at - 20 mV. Stimulation of mechanosensory pressure cells evoked calcium transients in NS neurons whose amplitude was a linear function of the amplitude of the postsynaptic response. The results evidenced that VACCs aid an efficient propagation of graded signals, turning the vast neuritic tree of NS cells into an electrically compact structure. © 2013 the American Physiological Society. Fil:Yang, S.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Vilarchao, M.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Rela, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Szczupak, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2013 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223077_v109_n3_p711_Yang http://hdl.handle.net/20.500.12110/paper_00223077_v109_n3_p711_Yang
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Calcium transients Low threshold spike Signal propagation fluorescent dye magnesium amplitude modulation article calcium conductance calcium transport controlled study depolarization evoked response ganglion leech membrane potential motoneuron nerve cell neurite nonhuman nonspiking neuron priority journal Action Potentials Animals Calcium Calcium Channels Ganglia, Invertebrate Leeches Mechanoreceptors Mechanotransduction, Cellular Motor Neurons Synaptic Potentials
spellingShingle	Calcium transients Low threshold spike Signal propagation fluorescent dye magnesium amplitude modulation article calcium conductance calcium transport controlled study depolarization evoked response ganglion leech membrane potential motoneuron nerve cell neurite nonhuman nonspiking neuron priority journal Action Potentials Animals Calcium Calcium Channels Ganglia, Invertebrate Leeches Mechanoreceptors Mechanotransduction, Cellular Motor Neurons Synaptic Potentials Yang, Sung Min Vilarchao, María Eugenia Rela, Lorena Szczupak, Lidia Wide propagation of graded signals in nonspiking neurons
topic_facet	Calcium transients Low threshold spike Signal propagation fluorescent dye magnesium amplitude modulation article calcium conductance calcium transport controlled study depolarization evoked response ganglion leech membrane potential motoneuron nerve cell neurite nonhuman nonspiking neuron priority journal Action Potentials Animals Calcium Calcium Channels Ganglia, Invertebrate Leeches Mechanoreceptors Mechanotransduction, Cellular Motor Neurons Synaptic Potentials
description	Signal processing in neuritic trees is ruled by the concerted action of passive and active membrane properties that, together, determine the degree of electrical compartmentalization of these trees. We analyzed how active properties modulate spatial propagation of graded signals in a pair of nonspiking (NS) neurons of the leech. NS neurons present a very extensive neuritic tree that mediates the interaction with all the excitatory motoneurons in leech ganglia. NS cells express voltageactivated Ca 2+ conductances (VACCs) that, under certain experimental conditions, evoke low-threshold spikes. We studied the distribution of calcium transients in NS neurons loaded with fluorescent calcium probes in response to low-threshold spikes, electrical depolarizing pulses, and synaptic inputs. The three types of stimuli evoked calcium transients of similar characteristics in the four main branches of the neuron. The magnitude of the calcium transients evoked by electrical pulses was a graded function of the change in NS membrane potential and depended on the baseline potential level. The underlying VACCs were partially inactivated at rest and strongly inactivated at - 20 mV. Stimulation of mechanosensory pressure cells evoked calcium transients in NS neurons whose amplitude was a linear function of the amplitude of the postsynaptic response. The results evidenced that VACCs aid an efficient propagation of graded signals, turning the vast neuritic tree of NS cells into an electrically compact structure. © 2013 the American Physiological Society.
author	Yang, Sung Min Vilarchao, María Eugenia Rela, Lorena Szczupak, Lidia
author_facet	Yang, Sung Min Vilarchao, María Eugenia Rela, Lorena Szczupak, Lidia
author_sort	Yang, Sung Min
title	Wide propagation of graded signals in nonspiking neurons
title_short	Wide propagation of graded signals in nonspiking neurons
title_full	Wide propagation of graded signals in nonspiking neurons
title_fullStr	Wide propagation of graded signals in nonspiking neurons
title_full_unstemmed	Wide propagation of graded signals in nonspiking neurons
title_sort	wide propagation of graded signals in nonspiking neurons
publishDate	2013
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223077_v109_n3_p711_Yang http://hdl.handle.net/20.500.12110/paper_00223077_v109_n3_p711_Yang
work_keys_str_mv	AT yangsungmin widepropagationofgradedsignalsinnonspikingneurons AT vilarchaomariaeugenia widepropagationofgradedsignalsinnonspikingneurons AT relalorena widepropagationofgradedsignalsinnonspikingneurons AT szczupaklidia widepropagationofgradedsignalsinnonspikingneurons
_version_	1768543071846268928

Wide propagation of graded signals in nonspiking neurons

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