Effect of a nonspiking neuron on motor patterns of the leech

Premotor and motoneurons could play regulatory roles in motor control. We have investigated the role of a premotor nonspiking (NS) neuron of the leech nervous system in two locomotive patterns: swimming and crawling. The NS neuron is coupled through rectifying electrical junctions to all the excitat...

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Autores principales:	Rodríguez, Mariano Julián, Szczupak, Lidia
Publicado:	2012
Materias:	Motoneurons Premotor inwardly rectifying potassium channel animal cell article cell population controlled study depolarization hyperpolarization leech locomotion membrane potential motoneuron motor performance nervous system nonhuman oscillation priority journal swimming Action Potentials Animals Dopamine Electric Stimulation Electrophysiology Leeches Motor Neurons Nervous System Patch-Clamp Techniques Swimming
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223077_v107_n7_p1917_Rodriguez http://hdl.handle.net/20.500.12110/paper_00223077_v107_n7_p1917_Rodriguez
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00223077_v107_n7_p1917_Rodriguez
record_format	dspace
spelling	paper:paper_00223077_v107_n7_p1917_Rodriguez2023-06-08T14:49:11Z Effect of a nonspiking neuron on motor patterns of the leech Rodríguez, Mariano Julián Szczupak, Lidia Motoneurons Premotor inwardly rectifying potassium channel animal cell article cell population controlled study depolarization hyperpolarization leech locomotion membrane potential motoneuron motor performance nervous system nonhuman oscillation priority journal swimming Action Potentials Animals Dopamine Electric Stimulation Electrophysiology Leeches Motor Neurons Nervous System Patch-Clamp Techniques Swimming Premotor and motoneurons could play regulatory roles in motor control. We have investigated the role of a premotor nonspiking (NS) neuron of the leech nervous system in two locomotive patterns: swimming and crawling. The NS neuron is coupled through rectifying electrical junctions to all the excitatory motoneurons examined. In addition, activation of motoneurons evokes chemically mediated inhibitory responses in NS. During swimming and crawling, the NS membrane potential (Vm NS) oscillated phase locked to the motor output. Hyperpolarization or depolarization of NS had no effect on swimming, but hyperpolarization of NS slowed down the crawling activity and decreased the motoneuron firing frequency. Depolarization of NS increased the motoneuron activity, and, at stages where the crawling pattern was fading, depolarization of NS reinstated it. Future work should determine if NS is actually a member of the central pattern generator or a regulatory element. © 2012 the American Physiological Society. Fil:Rodriguez, M.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Szczupak, L. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2012 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223077_v107_n7_p1917_Rodriguez http://hdl.handle.net/20.500.12110/paper_00223077_v107_n7_p1917_Rodriguez
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	Motoneurons Premotor inwardly rectifying potassium channel animal cell article cell population controlled study depolarization hyperpolarization leech locomotion membrane potential motoneuron motor performance nervous system nonhuman oscillation priority journal swimming Action Potentials Animals Dopamine Electric Stimulation Electrophysiology Leeches Motor Neurons Nervous System Patch-Clamp Techniques Swimming
spellingShingle	Motoneurons Premotor inwardly rectifying potassium channel animal cell article cell population controlled study depolarization hyperpolarization leech locomotion membrane potential motoneuron motor performance nervous system nonhuman oscillation priority journal swimming Action Potentials Animals Dopamine Electric Stimulation Electrophysiology Leeches Motor Neurons Nervous System Patch-Clamp Techniques Swimming Rodríguez, Mariano Julián Szczupak, Lidia Effect of a nonspiking neuron on motor patterns of the leech
topic_facet	Motoneurons Premotor inwardly rectifying potassium channel animal cell article cell population controlled study depolarization hyperpolarization leech locomotion membrane potential motoneuron motor performance nervous system nonhuman oscillation priority journal swimming Action Potentials Animals Dopamine Electric Stimulation Electrophysiology Leeches Motor Neurons Nervous System Patch-Clamp Techniques Swimming
description	Premotor and motoneurons could play regulatory roles in motor control. We have investigated the role of a premotor nonspiking (NS) neuron of the leech nervous system in two locomotive patterns: swimming and crawling. The NS neuron is coupled through rectifying electrical junctions to all the excitatory motoneurons examined. In addition, activation of motoneurons evokes chemically mediated inhibitory responses in NS. During swimming and crawling, the NS membrane potential (Vm NS) oscillated phase locked to the motor output. Hyperpolarization or depolarization of NS had no effect on swimming, but hyperpolarization of NS slowed down the crawling activity and decreased the motoneuron firing frequency. Depolarization of NS increased the motoneuron activity, and, at stages where the crawling pattern was fading, depolarization of NS reinstated it. Future work should determine if NS is actually a member of the central pattern generator or a regulatory element. © 2012 the American Physiological Society.
author	Rodríguez, Mariano Julián Szczupak, Lidia
author_facet	Rodríguez, Mariano Julián Szczupak, Lidia
author_sort	Rodríguez, Mariano Julián
title	Effect of a nonspiking neuron on motor patterns of the leech
title_short	Effect of a nonspiking neuron on motor patterns of the leech
title_full	Effect of a nonspiking neuron on motor patterns of the leech
title_fullStr	Effect of a nonspiking neuron on motor patterns of the leech
title_full_unstemmed	Effect of a nonspiking neuron on motor patterns of the leech
title_sort	effect of a nonspiking neuron on motor patterns of the leech
publishDate	2012
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00223077_v107_n7_p1917_Rodriguez http://hdl.handle.net/20.500.12110/paper_00223077_v107_n7_p1917_Rodriguez
work_keys_str_mv	AT rodriguezmarianojulian effectofanonspikingneurononmotorpatternsoftheleech AT szczupaklidia effectofanonspikingneurononmotorpatternsoftheleech
_version_	1768542068311851008

Effect of a nonspiking neuron on motor patterns of the leech

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