Prediction of Aquaporin Function by Integrating Evolutionary and Functional Analyses

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Aquaporins (AQPs) are a family of channel proteins, which transport water and/or small solutes across cell membranes. AQPs are present in Bacteria, Eukarya, and Archaea. The classical AQP evolution paradigm explains the inconsistent phylogenetic trees by multiple transfer events and emphasizes that...

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Autores principales: Soto, Gabriela Cynthia, Muschietti, Jorge P., Ayub, Nicolás Daniel
Publicado: 2013
Materias:
Aquaporin
Evolution
Function
Integration
Acceso en línea:https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00222631_v_n_p1_PerezDiGiorgio
http://hdl.handle.net/20.500.12110/paper_00222631_v_n_p1_PerezDiGiorgio
Aporte de:
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires
id paper:paper_00222631_v_n_p1_PerezDiGiorgio
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spelling paper:paper_00222631_v_n_p1_PerezDiGiorgio2023-06-08T14:48:41Z Prediction of Aquaporin Function by Integrating Evolutionary and Functional Analyses Soto, Gabriela Cynthia Muschietti, Jorge P. Ayub, Nicolás Daniel Aquaporin Evolution Function Integration Aquaporins (AQPs) are a family of channel proteins, which transport water and/or small solutes across cell membranes. AQPs are present in Bacteria, Eukarya, and Archaea. The classical AQP evolution paradigm explains the inconsistent phylogenetic trees by multiple transfer events and emphasizes that the assignment of orthologous AQPs is not possible, making it difficult to integrate functional information. Recently, a novel phylogenetic framework of eukaryotic AQP evolution showed congruence between eukaryotic AQPs and organismal trees identifying 32 orthologous clusters in plants and animals (Soto et al. Gene 503:165-176, 2012). In this article, we discuss in depth the methodological strength, the ability to predict functionality and the AQP community perception about the different paradigms of AQP evolution. Moreover, we show an updated review of AQPs transport functions in association with phylogenetic analyses. Finally, we discuss the possible effect of AQP data integration in the understanding of water and solute transport in eukaryotic cells. © 2013 Springer Science+Business Media New York. Fil:Soto, G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Muschietti, J.P. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Ayub, N.D. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2013 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00222631_v_n_p1_PerezDiGiorgio http://hdl.handle.net/20.500.12110/paper_00222631_v_n_p1_PerezDiGiorgio
institution Universidad de Buenos Aires
institution_str I-28
repository_str R-134
collection Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic Aquaporin
Evolution
Function
Integration
spellingShingle Aquaporin
Evolution
Function
Integration
Soto, Gabriela Cynthia
Muschietti, Jorge P.
Ayub, Nicolás Daniel
Prediction of Aquaporin Function by Integrating Evolutionary and Functional Analyses
topic_facet Aquaporin
Evolution
Function
Integration
description Aquaporins (AQPs) are a family of channel proteins, which transport water and/or small solutes across cell membranes. AQPs are present in Bacteria, Eukarya, and Archaea. The classical AQP evolution paradigm explains the inconsistent phylogenetic trees by multiple transfer events and emphasizes that the assignment of orthologous AQPs is not possible, making it difficult to integrate functional information. Recently, a novel phylogenetic framework of eukaryotic AQP evolution showed congruence between eukaryotic AQPs and organismal trees identifying 32 orthologous clusters in plants and animals (Soto et al. Gene 503:165-176, 2012). In this article, we discuss in depth the methodological strength, the ability to predict functionality and the AQP community perception about the different paradigms of AQP evolution. Moreover, we show an updated review of AQPs transport functions in association with phylogenetic analyses. Finally, we discuss the possible effect of AQP data integration in the understanding of water and solute transport in eukaryotic cells. © 2013 Springer Science+Business Media New York.
author Soto, Gabriela Cynthia
Muschietti, Jorge P.
Ayub, Nicolás Daniel
author_facet Soto, Gabriela Cynthia
Muschietti, Jorge P.
Ayub, Nicolás Daniel
author_sort Soto, Gabriela Cynthia
title Prediction of Aquaporin Function by Integrating Evolutionary and Functional Analyses
title_short Prediction of Aquaporin Function by Integrating Evolutionary and Functional Analyses
title_full Prediction of Aquaporin Function by Integrating Evolutionary and Functional Analyses
title_fullStr Prediction of Aquaporin Function by Integrating Evolutionary and Functional Analyses
title_full_unstemmed Prediction of Aquaporin Function by Integrating Evolutionary and Functional Analyses
title_sort prediction of aquaporin function by integrating evolutionary and functional analyses
publishDate 2013
url https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00222631_v_n_p1_PerezDiGiorgio
http://hdl.handle.net/20.500.12110/paper_00222631_v_n_p1_PerezDiGiorgio
work_keys_str_mv AT sotogabrielacynthia predictionofaquaporinfunctionbyintegratingevolutionaryandfunctionalanalyses
AT muschiettijorgep predictionofaquaporinfunctionbyintegratingevolutionaryandfunctionalanalyses
AT ayubnicolasdaniel predictionofaquaporinfunctionbyintegratingevolutionaryandfunctionalanalyses
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