Design, synthesis, and biological evaluation of new growth inhibitors of Trypanosoma cruzi (epimastigotes)

As a continuation of our project aimed at the search for new chemotherapeutic agents against Chagas' disease, several drugs structurally related to the insect growth regulator Fenoxycarb and the naturally occurring juvenfie hormone of insects were designed, synthesized, and evaluated as antipro...

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Autores principales:	Schvartzapel, Andrea Judith, Rodríguez, Juan Bautista, Gros, Eduardo Gervasio
Publicado:	1997
Materias:	3,7 dimethylocta 2,6 dien 1 yl ethylcarbamate 3,7 dimethylocta 2,6 dien 1 yl tetrahydro 2h pyran 2 yl ether 3,7,11 trimethyldodeca 2,6,10 trien 1 yl ethylcarbamate 3,7,11 trimethyldodeca 2,6,10 trien 1 yl tetrahydro 2h pyran 2 yl ether 4 benzoylphenyl prop 2 en 1 yl ether benznidazole fenoxycarb isoprenoid nifurtimox unclassified drug article chagas disease drug design drug synthesis epimastigote structure activity relation trypanosoma cruzi Animals Drug Design Magnetic Resonance Spectroscopy Mass Spectrometry Molecular Structure Spectrophotometry, Infrared Trypanocidal Agents Trypanosoma cruzi
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00222623_v40_n15_p2314_Schvartzapel http://hdl.handle.net/20.500.12110/paper_00222623_v40_n15_p2314_Schvartzapel
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00222623_v40_n15_p2314_Schvartzapel
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spelling	paper:paper_00222623_v40_n15_p2314_Schvartzapel2023-06-08T14:48:35Z Design, synthesis, and biological evaluation of new growth inhibitors of Trypanosoma cruzi (epimastigotes) Schvartzapel, Andrea Judith Rodríguez, Juan Bautista Gros, Eduardo Gervasio 3,7 dimethylocta 2,6 dien 1 yl ethylcarbamate 3,7 dimethylocta 2,6 dien 1 yl tetrahydro 2h pyran 2 yl ether 3,7,11 trimethyldodeca 2,6,10 trien 1 yl ethylcarbamate 3,7,11 trimethyldodeca 2,6,10 trien 1 yl tetrahydro 2h pyran 2 yl ether 4 benzoylphenyl prop 2 en 1 yl ether benznidazole fenoxycarb isoprenoid nifurtimox unclassified drug article chagas disease drug design drug synthesis epimastigote structure activity relation trypanosoma cruzi Animals Drug Design Magnetic Resonance Spectroscopy Mass Spectrometry Molecular Structure Spectrophotometry, Infrared Trypanocidal Agents Trypanosoma cruzi As a continuation of our project aimed at the search for new chemotherapeutic agents against Chagas' disease, several drugs structurally related to the insect growth regulator Fenoxycarb and the naturally occurring juvenfie hormone of insects were designed, synthesized, and evaluated as antiproliferative agents against the parasite responsible of this disease. Isoprenoid derivatives (compounds 33, 34, 36, and 37) were potent growth inhibitors of Trypanosoma cruzi epimastigotes. In addition, taking into account the high activity observed for compound 30 and the inhibitory action of related compounds, the allyl ether moiety bonded at the polar extreme of these inhibitors proved to be a promising group for the design of new drugs. Fil:Schvartzapel, A.J. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Rodriguez, J.B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Gros, E.G. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1997 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00222623_v40_n15_p2314_Schvartzapel http://hdl.handle.net/20.500.12110/paper_00222623_v40_n15_p2314_Schvartzapel
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	3,7 dimethylocta 2,6 dien 1 yl ethylcarbamate 3,7 dimethylocta 2,6 dien 1 yl tetrahydro 2h pyran 2 yl ether 3,7,11 trimethyldodeca 2,6,10 trien 1 yl ethylcarbamate 3,7,11 trimethyldodeca 2,6,10 trien 1 yl tetrahydro 2h pyran 2 yl ether 4 benzoylphenyl prop 2 en 1 yl ether benznidazole fenoxycarb isoprenoid nifurtimox unclassified drug article chagas disease drug design drug synthesis epimastigote structure activity relation trypanosoma cruzi Animals Drug Design Magnetic Resonance Spectroscopy Mass Spectrometry Molecular Structure Spectrophotometry, Infrared Trypanocidal Agents Trypanosoma cruzi
spellingShingle	3,7 dimethylocta 2,6 dien 1 yl ethylcarbamate 3,7 dimethylocta 2,6 dien 1 yl tetrahydro 2h pyran 2 yl ether 3,7,11 trimethyldodeca 2,6,10 trien 1 yl ethylcarbamate 3,7,11 trimethyldodeca 2,6,10 trien 1 yl tetrahydro 2h pyran 2 yl ether 4 benzoylphenyl prop 2 en 1 yl ether benznidazole fenoxycarb isoprenoid nifurtimox unclassified drug article chagas disease drug design drug synthesis epimastigote structure activity relation trypanosoma cruzi Animals Drug Design Magnetic Resonance Spectroscopy Mass Spectrometry Molecular Structure Spectrophotometry, Infrared Trypanocidal Agents Trypanosoma cruzi Schvartzapel, Andrea Judith Rodríguez, Juan Bautista Gros, Eduardo Gervasio Design, synthesis, and biological evaluation of new growth inhibitors of Trypanosoma cruzi (epimastigotes)
topic_facet	3,7 dimethylocta 2,6 dien 1 yl ethylcarbamate 3,7 dimethylocta 2,6 dien 1 yl tetrahydro 2h pyran 2 yl ether 3,7,11 trimethyldodeca 2,6,10 trien 1 yl ethylcarbamate 3,7,11 trimethyldodeca 2,6,10 trien 1 yl tetrahydro 2h pyran 2 yl ether 4 benzoylphenyl prop 2 en 1 yl ether benznidazole fenoxycarb isoprenoid nifurtimox unclassified drug article chagas disease drug design drug synthesis epimastigote structure activity relation trypanosoma cruzi Animals Drug Design Magnetic Resonance Spectroscopy Mass Spectrometry Molecular Structure Spectrophotometry, Infrared Trypanocidal Agents Trypanosoma cruzi
description	As a continuation of our project aimed at the search for new chemotherapeutic agents against Chagas' disease, several drugs structurally related to the insect growth regulator Fenoxycarb and the naturally occurring juvenfie hormone of insects were designed, synthesized, and evaluated as antiproliferative agents against the parasite responsible of this disease. Isoprenoid derivatives (compounds 33, 34, 36, and 37) were potent growth inhibitors of Trypanosoma cruzi epimastigotes. In addition, taking into account the high activity observed for compound 30 and the inhibitory action of related compounds, the allyl ether moiety bonded at the polar extreme of these inhibitors proved to be a promising group for the design of new drugs.
author	Schvartzapel, Andrea Judith Rodríguez, Juan Bautista Gros, Eduardo Gervasio
author_facet	Schvartzapel, Andrea Judith Rodríguez, Juan Bautista Gros, Eduardo Gervasio
author_sort	Schvartzapel, Andrea Judith
title	Design, synthesis, and biological evaluation of new growth inhibitors of Trypanosoma cruzi (epimastigotes)
title_short	Design, synthesis, and biological evaluation of new growth inhibitors of Trypanosoma cruzi (epimastigotes)
title_full	Design, synthesis, and biological evaluation of new growth inhibitors of Trypanosoma cruzi (epimastigotes)
title_fullStr	Design, synthesis, and biological evaluation of new growth inhibitors of Trypanosoma cruzi (epimastigotes)
title_full_unstemmed	Design, synthesis, and biological evaluation of new growth inhibitors of Trypanosoma cruzi (epimastigotes)
title_sort	design, synthesis, and biological evaluation of new growth inhibitors of trypanosoma cruzi (epimastigotes)
publishDate	1997
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00222623_v40_n15_p2314_Schvartzapel http://hdl.handle.net/20.500.12110/paper_00222623_v40_n15_p2314_Schvartzapel
work_keys_str_mv	AT schvartzapelandreajudith designsynthesisandbiologicalevaluationofnewgrowthinhibitorsoftrypanosomacruziepimastigotes AT rodriguezjuanbautista designsynthesisandbiologicalevaluationofnewgrowthinhibitorsoftrypanosomacruziepimastigotes AT groseduardogervasio designsynthesisandbiologicalevaluationofnewgrowthinhibitorsoftrypanosomacruziepimastigotes
_version_	1768546708927545344

Design, synthesis, and biological evaluation of new growth inhibitors of Trypanosoma cruzi (epimastigotes)

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