The role of N-β-alanyldopamine synthase in the innate immune response of two insects
Insects trigger a multifaceted innate immune response to fight microbial infections. We show that in the yellow mealworm, Tenebrio molitor, septic injuries induce the synthesis of N-β-alanyldopamine (NBAD), which is known as the main sclerotization precursor of insect brown cuticles. We demonstrate...
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Acceso en línea: | https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00221910_v53_n11_p1188_Schachter http://hdl.handle.net/20.500.12110/paper_00221910_v53_n11_p1188_Schachter |
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paper:paper_00221910_v53_n11_p1188_Schachter2023-06-08T14:47:11Z The role of N-β-alanyldopamine synthase in the innate immune response of two insects Pérez, Martín Mariano Quesada Allué, Luis Alberto β-alanine Ceratitis capitata Insect immunity N-β-alanyldopamine Tenebrio molitor catecholamine beta alanyl ligase catecholamine-beta-alanyl ligase dopamine drug derivative insect protein ligase N(beta) alanyldopamine N(beta)-alanyldopamine unclassified drug beetle enzyme activity fly immune response larva animal article enzyme induction enzymology epidermis Escherichia coli immunology innate immunity larva Mediterranean fruit fly metabolism microbiology physiology Tenebrio time Animals Ceratitis capitata Dopamine Enzyme Induction Epidermis Escherichia coli Immunity, Natural Insect Proteins Larva Ligases Tenebrio Time Factors Ceratitis capitata Escherichia coli Hexapoda Tenebrio Tenebrio molitor Insects trigger a multifaceted innate immune response to fight microbial infections. We show that in the yellow mealworm, Tenebrio molitor, septic injuries induce the synthesis of N-β-alanyldopamine (NBAD), which is known as the main sclerotization precursor of insect brown cuticles. We demonstrate that NBAD synthase is induced in the epidermis of the mealworm and of the Medfly, Ceratitis capitata, by infection with Escherichia coli. Our results indicate that synthesis of NBAD seems to be a novel component of the overall innate immune response in insects. © 2007 Elsevier Ltd. All rights reserved. Fil:Pérez, M.M. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Quesada-Allué, L.A. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 2007 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00221910_v53_n11_p1188_Schachter http://hdl.handle.net/20.500.12110/paper_00221910_v53_n11_p1188_Schachter |
institution |
Universidad de Buenos Aires |
institution_str |
I-28 |
repository_str |
R-134 |
collection |
Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) |
topic |
β-alanine Ceratitis capitata Insect immunity N-β-alanyldopamine Tenebrio molitor catecholamine beta alanyl ligase catecholamine-beta-alanyl ligase dopamine drug derivative insect protein ligase N(beta) alanyldopamine N(beta)-alanyldopamine unclassified drug beetle enzyme activity fly immune response larva animal article enzyme induction enzymology epidermis Escherichia coli immunology innate immunity larva Mediterranean fruit fly metabolism microbiology physiology Tenebrio time Animals Ceratitis capitata Dopamine Enzyme Induction Epidermis Escherichia coli Immunity, Natural Insect Proteins Larva Ligases Tenebrio Time Factors Ceratitis capitata Escherichia coli Hexapoda Tenebrio Tenebrio molitor |
spellingShingle |
β-alanine Ceratitis capitata Insect immunity N-β-alanyldopamine Tenebrio molitor catecholamine beta alanyl ligase catecholamine-beta-alanyl ligase dopamine drug derivative insect protein ligase N(beta) alanyldopamine N(beta)-alanyldopamine unclassified drug beetle enzyme activity fly immune response larva animal article enzyme induction enzymology epidermis Escherichia coli immunology innate immunity larva Mediterranean fruit fly metabolism microbiology physiology Tenebrio time Animals Ceratitis capitata Dopamine Enzyme Induction Epidermis Escherichia coli Immunity, Natural Insect Proteins Larva Ligases Tenebrio Time Factors Ceratitis capitata Escherichia coli Hexapoda Tenebrio Tenebrio molitor Pérez, Martín Mariano Quesada Allué, Luis Alberto The role of N-β-alanyldopamine synthase in the innate immune response of two insects |
topic_facet |
β-alanine Ceratitis capitata Insect immunity N-β-alanyldopamine Tenebrio molitor catecholamine beta alanyl ligase catecholamine-beta-alanyl ligase dopamine drug derivative insect protein ligase N(beta) alanyldopamine N(beta)-alanyldopamine unclassified drug beetle enzyme activity fly immune response larva animal article enzyme induction enzymology epidermis Escherichia coli immunology innate immunity larva Mediterranean fruit fly metabolism microbiology physiology Tenebrio time Animals Ceratitis capitata Dopamine Enzyme Induction Epidermis Escherichia coli Immunity, Natural Insect Proteins Larva Ligases Tenebrio Time Factors Ceratitis capitata Escherichia coli Hexapoda Tenebrio Tenebrio molitor |
description |
Insects trigger a multifaceted innate immune response to fight microbial infections. We show that in the yellow mealworm, Tenebrio molitor, septic injuries induce the synthesis of N-β-alanyldopamine (NBAD), which is known as the main sclerotization precursor of insect brown cuticles. We demonstrate that NBAD synthase is induced in the epidermis of the mealworm and of the Medfly, Ceratitis capitata, by infection with Escherichia coli. Our results indicate that synthesis of NBAD seems to be a novel component of the overall innate immune response in insects. © 2007 Elsevier Ltd. All rights reserved. |
author |
Pérez, Martín Mariano Quesada Allué, Luis Alberto |
author_facet |
Pérez, Martín Mariano Quesada Allué, Luis Alberto |
author_sort |
Pérez, Martín Mariano |
title |
The role of N-β-alanyldopamine synthase in the innate immune response of two insects |
title_short |
The role of N-β-alanyldopamine synthase in the innate immune response of two insects |
title_full |
The role of N-β-alanyldopamine synthase in the innate immune response of two insects |
title_fullStr |
The role of N-β-alanyldopamine synthase in the innate immune response of two insects |
title_full_unstemmed |
The role of N-β-alanyldopamine synthase in the innate immune response of two insects |
title_sort |
role of n-β-alanyldopamine synthase in the innate immune response of two insects |
publishDate |
2007 |
url |
https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00221910_v53_n11_p1188_Schachter http://hdl.handle.net/20.500.12110/paper_00221910_v53_n11_p1188_Schachter |
work_keys_str_mv |
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1768542491772977152 |