Differentiation of junin virus and antigenic variants isolated in vivo by kinetic neutralization assays

The major natural reservoir of Junin virus, the aetiological agent of Argentine haemorrhagic fever, is the cricetid Calomys musculinus. Neonatal animals experimentally infected with Junin virus (XJCl3 strain) developed typical disease and approximately 80% of them died. Most survivors become persist...

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Detalles Bibliográficos
Autores principales:	Alche, Laura Edith, Coto, Celia Esther
Publicado:	1988
Materias:	antigenic variation Junin virus nonhuman Animalia Argentina (fish) Calomys musculinus Cricetinae
Acceso en línea:	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00221317_v69_n8_p2123_Alche http://hdl.handle.net/20.500.12110/paper_00221317_v69_n8_p2123_Alche
Aporte de:	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA) de Universidad de Buenos Aires

id	paper:paper_00221317_v69_n8_p2123_Alche
record_format	dspace
spelling	paper:paper_00221317_v69_n8_p2123_Alche2023-06-08T14:46:31Z Differentiation of junin virus and antigenic variants isolated in vivo by kinetic neutralization assays Alche, Laura Edith Coto, Celia Esther antigenic variation Junin virus nonhuman Animalia Argentina (fish) Calomys musculinus Cricetinae Junin virus The major natural reservoir of Junin virus, the aetiological agent of Argentine haemorrhagic fever, is the cricetid Calomys musculinus. Neonatal animals experimentally infected with Junin virus (XJCl3 strain) developed typical disease and approximately 80% of them died. Most survivors become persistently infected. Antigenically variant viruses were isolated from the blood and brain of infected cricetids during the acute and chronic stages of the disease. These variants could be distinguished from the parental strain by kinetic neutralization assays using polyclonal antibodies. Some biological properties were shared with the parental virus strain including its virulence for newborn C. musculinus. These variant viruses may play a major role in chronic disease since we have shown that a viral isolate from an infected brain was poorly neutralized by serum obtained from the same animal. Fil:Alche, L.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Fil:Coto, C.E. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. 1988 https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00221317_v69_n8_p2123_Alche http://hdl.handle.net/20.500.12110/paper_00221317_v69_n8_p2123_Alche
institution	Universidad de Buenos Aires
institution_str	I-28
repository_str	R-134
collection	Biblioteca Digital - Facultad de Ciencias Exactas y Naturales (UBA)
topic	antigenic variation Junin virus nonhuman Animalia Argentina (fish) Calomys musculinus Cricetinae Junin virus
spellingShingle	antigenic variation Junin virus nonhuman Animalia Argentina (fish) Calomys musculinus Cricetinae Junin virus Alche, Laura Edith Coto, Celia Esther Differentiation of junin virus and antigenic variants isolated in vivo by kinetic neutralization assays
topic_facet	antigenic variation Junin virus nonhuman Animalia Argentina (fish) Calomys musculinus Cricetinae Junin virus
description	The major natural reservoir of Junin virus, the aetiological agent of Argentine haemorrhagic fever, is the cricetid Calomys musculinus. Neonatal animals experimentally infected with Junin virus (XJCl3 strain) developed typical disease and approximately 80% of them died. Most survivors become persistently infected. Antigenically variant viruses were isolated from the blood and brain of infected cricetids during the acute and chronic stages of the disease. These variants could be distinguished from the parental strain by kinetic neutralization assays using polyclonal antibodies. Some biological properties were shared with the parental virus strain including its virulence for newborn C. musculinus. These variant viruses may play a major role in chronic disease since we have shown that a viral isolate from an infected brain was poorly neutralized by serum obtained from the same animal.
author	Alche, Laura Edith Coto, Celia Esther
author_facet	Alche, Laura Edith Coto, Celia Esther
author_sort	Alche, Laura Edith
title	Differentiation of junin virus and antigenic variants isolated in vivo by kinetic neutralization assays
title_short	Differentiation of junin virus and antigenic variants isolated in vivo by kinetic neutralization assays
title_full	Differentiation of junin virus and antigenic variants isolated in vivo by kinetic neutralization assays
title_fullStr	Differentiation of junin virus and antigenic variants isolated in vivo by kinetic neutralization assays
title_full_unstemmed	Differentiation of junin virus and antigenic variants isolated in vivo by kinetic neutralization assays
title_sort	differentiation of junin virus and antigenic variants isolated in vivo by kinetic neutralization assays
publishDate	1988
url	https://bibliotecadigital.exactas.uba.ar/collection/paper/document/paper_00221317_v69_n8_p2123_Alche http://hdl.handle.net/20.500.12110/paper_00221317_v69_n8_p2123_Alche
work_keys_str_mv	AT alchelauraedith differentiationofjuninvirusandantigenicvariantsisolatedinvivobykineticneutralizationassays AT cotoceliaesther differentiationofjuninvirusandantigenicvariantsisolatedinvivobykineticneutralizationassays
_version_	1768544764094840832

Differentiation of junin virus and antigenic variants isolated in vivo by kinetic neutralization assays

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